Instructions marked as FrameSetup do not cause requestLabelAfterInsn to be called and so no such label is generated. Call instructions which require call site entries to be generated require this label to be present in order to calculate the return PC offset/address, but the check for whether the call instruction is marked as FrameSetup was not present.
Therefore in the case where a call instruction is marked as FrameSetup, an assertion failure occurs if a call site entry is to be generated. This is the case with RISC-V's implementation of save/restore via library calls (see https://reviews.llvm.org/D62686).