I'm not sure this would catch all such issues, but it would catch some.
The problem for PR49393 was that we were holding a reference to a node that
wasn't connect edto the DAG across a function that could delete unused nodes. In
this particular case we managed to try to use the deleted node while it was in
the deleted state before its memory got recycled.
It could also happen that we delete the node, something allocates a new node
which recycles the memory. Then we try to use the reference we were holding and
it is now a completely different node with different valid opcode. This patch
would not catch that.