The MVE VLD2/4 and VST2/4 instructions require the pointer to be aligned to at least the size of the element type. This adds a check for that into the ARM lowerInterleavedStore and lowerInterleavedLoad functions, not creating the intrinsics if they are not valid for the alignment of the load/store.
Unfortunately this is one of those bug fixes that does effect some useful codegen, as we were able to sometimes do some nice lowering of q15 types. But they can cause problem with low-enough aligned pointers.