This patch adds an optimization to clang-scan-deps and clang's preprocessor that skips excluded preprocessor blocks by bumping the lexer pointer, and not lexing the tokens until reaching appropriate #else/#endif directive. The skip positions and lexer offsets are computed when the file is minimized, directly from the minimized tokens.
On an 18-core iMacPro with macOS Catalina Beta I got 10-15% speed-up from this optimization when running clang-scan-deps on the compilation database for a recent LLVM and Clang (3511 files).
This kinda sounds like it can be called multiple times. Is there any way you can use chained pp callbacks?