diff --git a/clang/include/clang/StaticAnalyzer/Core/PathSensitive/BasicValueFactory.h b/clang/include/clang/StaticAnalyzer/Core/PathSensitive/BasicValueFactory.h
--- a/clang/include/clang/StaticAnalyzer/Core/PathSensitive/BasicValueFactory.h
+++ b/clang/include/clang/StaticAnalyzer/Core/PathSensitive/BasicValueFactory.h
@@ -139,6 +139,12 @@
 
   /// Returns the type of the APSInt used to store values of the given QualType.
   APSIntType getAPSIntType(QualType T) const {
+    // For the purposes of the analysis and constraints, we treat atomics
+    // as their underlying types.
+    if (const AtomicType *AT = T->getAs<AtomicType>()) {
+      T = AT->getValueType();
+    }
+
     assert(T->isIntegralOrEnumerationType() || Loc::isLocType(T));
     return APSIntType(Ctx.getIntWidth(T),
                       !T->isSignedIntegerOrEnumerationType());
diff --git a/clang/test/Analysis/atomics.c b/clang/test/Analysis/atomics.c
--- a/clang/test/Analysis/atomics.c
+++ b/clang/test/Analysis/atomics.c
@@ -93,3 +93,11 @@
   clang_analyzer_eval(s->refCount == 3); // expected-warning {{UNKNOWN}}
   clang_analyzer_eval(expected == 2); // expected-warning {{UNKNOWN}}
 }
+
+// PR49422
+void test_atomic_compare(int input) {
+  _Atomic(int) x = input;
+  if (x > 0) {
+    // no crash
+  }
+}