Index: clang/lib/Driver/ToolChains/AMDGPU.cpp
===================================================================
--- clang/lib/Driver/ToolChains/AMDGPU.cpp
+++ clang/lib/Driver/ToolChains/AMDGPU.cpp
@@ -186,6 +186,12 @@
     ROCmSearchDirs.emplace_back(RocmPathArg.str());
     DoPrintROCmSearchDirs();
     return ROCmSearchDirs;
+  } else if (const char *RocmPathEnv = ::getenv("ROCM_PATH")) {
+    if (!StringRef(RocmPathEnv).empty()) {
+      ROCmSearchDirs.emplace_back(RocmPathEnv);
+      DoPrintROCmSearchDirs();
+      return ROCmSearchDirs;
+    }
   }
 
   // Try to find relative to the compiler binary.
@@ -247,6 +253,28 @@
 
   ROCmSearchDirs.emplace_back(D.SysRoot + "/opt/rocm",
                               /*StrictChecking=*/true);
+
+  // Find the latest /opt/rocm-{release} directory.
+  std::error_code EC;
+  std::string LatestROCm;
+  for (llvm::vfs::directory_iterator
+           File = D.getVFS().dir_begin(D.SysRoot + "/opt", EC),
+           FileEnd;
+       File != FileEnd && !EC; File.increment(EC)) {
+    llvm::StringRef FileName = llvm::sys::path::filename(File->path());
+    if (!FileName.startswith("rocm-"))
+      continue;
+    if (LatestROCm.empty()) {
+      LatestROCm = FileName.str();
+      continue;
+    }
+    if (LatestROCm < FileName)
+      LatestROCm = FileName.str();
+  }
+  if (!LatestROCm.empty())
+    ROCmSearchDirs.emplace_back(D.SysRoot + "/opt/" + LatestROCm,
+                                /*StrictChecking=*/true);
+
   DoPrintROCmSearchDirs();
   return ROCmSearchDirs;
 }
Index: clang/test/Driver/rocm-detect.hip
===================================================================
--- clang/test/Driver/rocm-detect.hip
+++ clang/test/Driver/rocm-detect.hip
@@ -21,6 +21,21 @@
 // RUN:   --rocm-path=%S/Inputs/rocm %s 2>&1 \
 // RUN:   | FileCheck -check-prefixes=COMMON,NODEFAULTLIBS %s
 
+// Test environment variable ROCM_PATH.
+// RUN: env ROCM_PATH=%S/Inputs/rocm %clang -### -target x86_64-linux-gnu \
+// RUN:   --print-rocm-search-dirs %s 2>&1 \
+// RUN:   | FileCheck -check-prefixes=ROCM-ENV %s
+
+// Test detecting latest /opt/rocm-{release} directory.
+// RUN: rm -rf %T/opt/rocm-4.0.0
+// RUN: rm -rf %T/opt/rocm-4.2.0-6566
+// RUN: mkdir -p %T/opt
+// RUN: cp -r %S/Inputs/rocm %T/opt/rocm-4.0.0
+// RUN: cp -r %S/Inputs/rocm %T/opt/rocm-4.1.0
+// RUN: %clang -### -target x86_64-linux-gnu --sysroot=%T \
+// RUN:   --print-rocm-search-dirs %s 2>&1 \
+// RUN:   | FileCheck -check-prefixes=ROCM-REL %s
+
 // Test ROCm installation built by SPACK by invoke clang at %T/rocm-spack/llvm-amdgpu-*
 // directory through a soft link.
 
@@ -60,6 +75,11 @@
 
 // COMMON: "-triple" "amdgcn-amd-amdhsa"
 
+// ROCM-ENV: ROCm installation search path: {{.*}}/Inputs/rocm
+
+// ROCM-REL: ROCm installation search path: {{.*}}/opt/rocm
+// ROCM-REL: ROCm installation search path: {{.*}}/opt/rocm-4.1.0
+
 // SPACK: ROCm installation search path (Spack 4.0.0): [[DIR:.*]]
 // SPACK: ROCm installation search path: [[CLANG:.*]]
 // SPACK: ROCm installation search path: [[CLANG]]/lib/clang/{{[0-9.]+}}