diff --git a/llvm/lib/CodeGen/GlobalISel/Utils.cpp b/llvm/lib/CodeGen/GlobalISel/Utils.cpp
--- a/llvm/lib/CodeGen/GlobalISel/Utils.cpp
+++ b/llvm/lib/CodeGen/GlobalISel/Utils.cpp
@@ -200,6 +200,10 @@
   // Don't delete frame allocation labels.
   if (MI.getOpcode() == TargetOpcode::LOCAL_ESCAPE)
     return false;
+  // LIFETIME markers should be preserved even if they seem dead.
+  if (MI.getOpcode() == TargetOpcode::LIFETIME_START ||
+      MI.getOpcode() == TargetOpcode::LIFETIME_END)
+    return false;
 
   // If we can move an instruction, we can remove it.  Otherwise, it has
   // a side-effect of some sort.
diff --git a/llvm/test/CodeGen/AArch64/GlobalISel/lifetime-marker-no-dce.mir b/llvm/test/CodeGen/AArch64/GlobalISel/lifetime-marker-no-dce.mir
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/AArch64/GlobalISel/lifetime-marker-no-dce.mir
@@ -0,0 +1,43 @@
+# NOTE: Assertions have been autogenerated by utils/update_mir_test_checks.py
+# RUN: llc -run-pass=aarch64-prelegalizer-combiner -global-isel -verify-machineinstrs %s -o - | FileCheck %s
+# Check that we don't DCE the lifetime markers even though they don't have any users.
+--- |
+  target datalayout = "e-m:e-i8:8:32-i16:16:32-i64:64-i128:128-n32:64-S128"
+  target triple = "aarch64"
+
+  declare void @llvm.lifetime.start.p0i8(i64 immarg, i8* nocapture) #0
+  declare void @llvm.lifetime.end.p0i8(i64 immarg, i8* nocapture) #0
+
+  define void @test_lifetime_no_dce() {
+    %slot = alloca i8, i32 4, align 4
+    call void @llvm.lifetime.start.p0i8(i64 0, i8* %slot)
+    call void @llvm.lifetime.end.p0i8(i64 0, i8* %slot)
+    ret void
+  }
+
+  attributes #0 = { argmemonly nofree nosync nounwind willreturn }
+
+...
+---
+name:            test_lifetime_no_dce
+alignment:       4
+tracksRegLiveness: true
+registers:
+  - { id: 0, class: _ }
+frameInfo:
+  maxAlignment:    4
+stack:
+  - { id: 0, name: slot, size: 4, alignment: 4 }
+machineFunctionInfo: {}
+body:             |
+  bb.1 (%ir-block.0):
+    ; CHECK-LABEL: name: test_lifetime_no_dce
+    ; CHECK: LIFETIME_START %stack.0.slot
+    ; CHECK: LIFETIME_END %stack.0.slot
+    ; CHECK: RET_ReallyLR
+    %0:_(p0) = G_FRAME_INDEX %stack.0.slot
+    LIFETIME_START %stack.0.slot
+    LIFETIME_END %stack.0.slot
+    RET_ReallyLR
+
+...