Index: test/functionalities/plugins/commands/TestPluginCommands.py
===================================================================
--- test/functionalities/plugins/commands/TestPluginCommands.py
+++ test/functionalities/plugins/commands/TestPluginCommands.py
@@ -22,6 +22,7 @@
     @expectedFailureFreeBSD('llvm.org/pr17430')
     @skipIfi386 # This test links against liblldb.so. Thus, the test requires a 32-bit liblldb.so.
     @skipIfNoSBHeaders
+    @skipIfHostIncompatibleWithRemote
     def test_load_plugin(self):
         """Test that plugins that load commands work correctly."""
 
Index: test/lldbtest.py
===================================================================
--- test/lldbtest.py
+++ test/lldbtest.py
@@ -727,6 +727,19 @@
     """Returns true if the OS triple for the selected platform is any valid apple OS"""
     return getPlatform() in getDarwinOSTriples()
 
+def skipIfHostIncompatibleWithRemote(func):
+    """Decorate the item to skip tests if binaries built on this host are incompatible."""
+    if sys.platform.startswith('darwin'):
+        return skipUnlessPlatform(getDarwinOSTriples())(func)
+    elif sys.platform.startswith('linux'):
+        return skipUnlessPlatform(['linux'])(func)
+    elif sys.platform.startswith('freebsd'):
+        return skipUnlessPlatform(['freebsd'])(func)
+    elif sys.platform.startswith('win32'):
+        return skipUnlessPlatform(['windows'])(func)
+    # Unknown host platform, skip if remote is a recognized platform above.
+    return skipIfPlatform(['freebsd', 'linux', 'windows'].append(getDarwinOSTriples()))(func)
+
 def skipIfPlatform(oslist):
     """Decorate the item to skip tests if running on one of the listed platforms."""
     return unittest2.skipIf(getPlatform() in oslist,