diff --git a/clang/test/utils/update_cc_test_checks/Inputs/exec-all-runlines.c b/clang/test/utils/update_cc_test_checks/Inputs/exec-all-runlines.c
new file mode 100644
--- /dev/null
+++ b/clang/test/utils/update_cc_test_checks/Inputs/exec-all-runlines.c
@@ -0,0 +1,10 @@
+// Check that the non-clang/non-filechecked runlines execute
+// RUN: cp %s %s.copy.c
+// RUN: %clang_cc1 -triple x86_64-unknown-linux-gnu -fopenmp %s.copy.c -emit-llvm-bc -o %t-host.bc
+// RUN: %clang_cc1 -triple x86_64-unknown-linux-gnu -fopenmp -fopenmp-host-ir-file-path %t-host.bc %s.copy.c -emit-llvm -o - | FileCheck %s
+
+void use(int);
+
+void test(int a)
+{
+}
diff --git a/clang/test/utils/update_cc_test_checks/Inputs/exec-all-runlines.c.expected b/clang/test/utils/update_cc_test_checks/Inputs/exec-all-runlines.c.expected
new file mode 100644
--- /dev/null
+++ b/clang/test/utils/update_cc_test_checks/Inputs/exec-all-runlines.c.expected
@@ -0,0 +1,17 @@
+// NOTE: Assertions have been autogenerated by utils/update_cc_test_checks.py
+// Check that the non-clang/non-filechecked runlines execute
+// RUN: cp %s %s.copy.c
+// RUN: %clang_cc1 -triple x86_64-unknown-linux-gnu -fopenmp %s.copy.c -emit-llvm-bc -o %t-host.bc
+// RUN: %clang_cc1 -triple x86_64-unknown-linux-gnu -fopenmp -fopenmp-host-ir-file-path %t-host.bc %s.copy.c -emit-llvm -o - | FileCheck %s
+
+void use(int);
+
+// CHECK-LABEL: @test(
+// CHECK-NEXT:  entry:
+// CHECK-NEXT:    [[A_ADDR:%.*]] = alloca i32, align 4
+// CHECK-NEXT:    store i32 [[A:%.*]], i32* [[A_ADDR]], align 4
+// CHECK-NEXT:    ret void
+//
+void test(int a)
+{
+}
diff --git a/clang/test/utils/update_cc_test_checks/exec-all-runlines.test b/clang/test/utils/update_cc_test_checks/exec-all-runlines.test
new file mode 100644
--- /dev/null
+++ b/clang/test/utils/update_cc_test_checks/exec-all-runlines.test
@@ -0,0 +1,8 @@
+## Test that non-clang/non-filechecked runlines execute
+
+# RUN: cp %S/Inputs/exec-all-runlines.c %t-generated.c && %update_cc_test_checks %t-generated.c
+# RUN: diff -u %S/Inputs/exec-all-runlines.c.expected %t-generated.c
+
+## Check that re-running update_cc_test_checks doesn't change the output
+# RUN: %update_cc_test_checks %t-generated.c
+# RUN: diff -u %S/Inputs/exec-all-runlines.c.expected %t-generated.c
diff --git a/llvm/utils/update_cc_test_checks.py b/llvm/utils/update_cc_test_checks.py
--- a/llvm/utils/update_cc_test_checks.py
+++ b/llvm/utils/update_cc_test_checks.py
@@ -203,6 +203,14 @@
           'are discouraged in Clang testsuite.', file=sys.stderr)
     sys.exit(1)
 
+def exec_run_line(exe):
+  popen = subprocess.Popen(exe, stdout=subprocess.PIPE, stderr=subprocess.PIPE, universal_newlines=True)
+  stdout, stderr = popen.communicate()
+  if popen.returncode != 0:
+    sys.stderr.write('Failed to run ' + ' '.join(exe) + '\n')
+    sys.stderr.write(stderr)
+    sys.stderr.write(stdout)
+    sys.exit(3)
 
 def main():
   initial_args, parser = config()
@@ -221,25 +229,31 @@
       if m:
         triple_in_cmd = m.groups()[0]
 
-      # Apply %clang substitution rule, replace %s by `filename`, and append args.clang_args
-      clang_args = shlex.split(commands[0])
-      if clang_args[0] not in SUBST:
-        print('WARNING: Skipping non-clang RUN line: ' + l, file=sys.stderr)
+      # Parse executable args.
+      exec_args = shlex.split(commands[0])
+      # Execute non-clang runline.
+      if exec_args[0] not in SUBST:
+        print('NOTE: Executing non-clang RUN line: ' + l, file=sys.stderr)
+        # Replace %s by `filename`.
+        exec_args = [i.replace('%s', ti.path) if '%s' in i else i for i in exec_args]
+        exec_run_line(exec_args)
         continue
+      # This is a clang runline, apply %clang substitution rule, replace %s by `filename`,
+      # and append args.clang_args
+      clang_args = exec_args
       clang_args[0:1] = SUBST[clang_args[0]]
-      clang_args = [ti.path if i == '%s' else i for i in clang_args] + ti.args.clang_args
-
-      # Permit piping the output through opt
-      if not (len(commands) == 2 or
-              (len(commands) == 3 and commands[1].startswith('opt'))):
-        print('WARNING: Skipping non-clang RUN line: ' + l, file=sys.stderr)
+      clang_args = [i.replace('%s', ti.path) if '%s' in i else i for i in clang_args] + ti.args.clang_args
 
       # Extract -check-prefix in FileCheck args
       filecheck_cmd = commands[-1]
       common.verify_filecheck_prefixes(filecheck_cmd)
       if not filecheck_cmd.startswith('FileCheck '):
-        print('WARNING: Skipping non-FileChecked RUN line: ' + l, file=sys.stderr)
+        print('NOTE: Executing non-FileChecked clang RUN line: ' + l, file=sys.stderr)
+        # Execute non-filechecked clang runline.
+        exe = [ti.args.clang] + clang_args
+        exec_run_line(exe)
         continue
+
       check_prefixes = [item for m in common.CHECK_PREFIX_RE.finditer(filecheck_cmd)
                                for item in m.group(1).split(',')]
       if not check_prefixes: