Index: llvm/lib/Analysis/IVDescriptors.cpp
===================================================================
--- llvm/lib/Analysis/IVDescriptors.cpp
+++ llvm/lib/Analysis/IVDescriptors.cpp
@@ -198,6 +198,10 @@
   if (Phi->getNumIncomingValues() != 2)
     return false;
 
+  // Pointer min/max may be allowed, but it is not supported as a reduction op.
+  if (Phi->getType()->isPointerTy())
+    return false;
+
   // Reduction variables are only found in the loop header block.
   if (Phi->getParent() != TheLoop->getHeader())
     return false;
Index: llvm/test/Transforms/LoopVectorize/reduction-ptr.ll
===================================================================
--- /dev/null
+++ llvm/test/Transforms/LoopVectorize/reduction-ptr.ll
@@ -0,0 +1,40 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt < %s  -loop-vectorize -force-vector-width=4 -S | FileCheck %s
+
+target datalayout = "e-m:o-p270:32:32-p271:32:32-p272:64:64-i64:64-f80:128-n8:16:32:64-S128"
+
+; Reductions of pointer types are not supported.
+
+define void @PR49215(i32* %p, i32* %q) {
+; CHECK-LABEL: @PR49215(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    br label [[FOR_BODY:%.*]]
+; CHECK:       for.body:
+; CHECK-NEXT:    [[IV:%.*]] = phi i64 [ 0, [[ENTRY:%.*]] ], [ [[IV_NEXT:%.*]], [[FOR_BODY]] ]
+; CHECK-NEXT:    [[G:%.*]] = phi i32* [ [[P:%.*]], [[ENTRY]] ], [ [[UMIN:%.*]], [[FOR_BODY]] ]
+; CHECK-NEXT:    [[CMP2:%.*]] = icmp ult i32* [[Q:%.*]], [[G]]
+; CHECK-NEXT:    [[UMIN]] = select i1 [[CMP2]], i32* [[Q]], i32* [[G]]
+; CHECK-NEXT:    [[IV_NEXT]] = add nuw nsw i64 [[IV]], 1
+; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp eq i64 [[IV_NEXT]], undef
+; CHECK-NEXT:    br i1 [[EXITCOND]], label [[LOOPEXIT:%.*]], label [[FOR_BODY]]
+; CHECK:       loopexit:
+; CHECK-NEXT:    [[UMIN_LCSSA:%.*]] = phi i32* [ [[UMIN]], [[FOR_BODY]] ]
+; CHECK-NEXT:    [[PHI_CAST:%.*]] = ptrtoint i32* [[UMIN_LCSSA]] to i64
+; CHECK-NEXT:    ret void
+;
+entry:
+  br label %for.body
+
+for.body:
+  %iv = phi i64 [ 0, %entry ], [ %iv.next, %for.body ]
+  %g = phi i32* [ %p, %entry ], [ %umin, %for.body ]
+  %cmp2 = icmp ult i32* %q, %g
+  %umin = select i1 %cmp2, i32* %q, i32* %g
+  %iv.next = add nuw nsw i64 %iv, 1
+  %exitcond = icmp eq i64 %iv.next, undef
+  br i1 %exitcond, label %loopexit, label %for.body
+
+loopexit:
+  %phi.cast = ptrtoint i32* %umin to i64
+  ret void
+}