diff --git a/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt b/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt
--- a/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt
+++ b/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt
@@ -172,7 +172,15 @@
     list(GET ptx_feature_list ${itr} ptx_num)
     set(cuda_flags ${sm_flags})
     list(APPEND cuda_flags -Xclang -target-feature -Xclang +ptx${ptx_num})
-    list(APPEND cuda_flags "-DCUDA_VERSION=${cuda_version}00")
+    if("${cuda_version}" MATCHES "^([0-9]+)([0-9])$")
+      set(cuda_version_major ${CMAKE_MATCH_1})
+      set(cuda_version_minor ${CMAKE_MATCH_2})
+    else()
+      libomptarget_error_say(
+        "Unrecognized CUDA version format: ${cuda_version}")
+    endif()
+    list(APPEND cuda_flags
+      "-DCUDA_VERSION=${cuda_version_major}0${cuda_version_minor}0")
 
     set(bc_files "")
     foreach(src ${cuda_src_files})