diff --git a/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp b/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
--- a/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
+++ b/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
@@ -1911,6 +1911,11 @@
     };
 
     Ptr = Ptr->stripPointerCasts();
+    if (auto *I = dyn_cast<Instruction>(Ptr)) {
+      if (I->getParent() == &I->getFunction()->getEntryBlock()) {
+        return true;
+      }
+    }
     if (auto *GEP = dyn_cast<GEPOperator>(Ptr)) {
       return IsGuaranteedLoopInvariantBase(GEP->getPointerOperand()) &&
              GEP->hasAllConstantIndices();