diff --git a/clang/lib/CodeGen/BackendUtil.cpp b/clang/lib/CodeGen/BackendUtil.cpp
--- a/clang/lib/CodeGen/BackendUtil.cpp
+++ b/clang/lib/CodeGen/BackendUtil.cpp
@@ -1544,6 +1544,10 @@
     Conf.CGFileType = getCodeGenFileType(Action);
     break;
   }
+  Triple TargetTriple(M->getTargetTriple());
+  Conf.OptPassBuilderHook = [&](PassBuilder &PB) {
+    addSanitizers(TargetTriple, CGOpts, LOpts, PB);
+  };
   if (Error E =
           thinBackend(Conf, -1, AddStream, *M, *CombinedIndex, ImportList,
                       ModuleToDefinedGVSummaries[M->getModuleIdentifier()],
diff --git a/llvm/include/llvm/LTO/Config.h b/llvm/include/llvm/LTO/Config.h
--- a/llvm/include/llvm/LTO/Config.h
+++ b/llvm/include/llvm/LTO/Config.h
@@ -50,6 +50,8 @@
   std::vector<std::string> PassPlugins;
   /// For adding passes that run right before codegen.
   std::function<void(legacy::PassManager &)> PreCodeGenPassesHook;
+  /// For adding passes that run by opt.
+  std::function<void(PassBuilder &)> OptPassBuilderHook;
   Optional<Reloc::Model> RelocModel = Reloc::PIC_;
   Optional<CodeModel::Model> CodeModel = None;
   CodeGenOpt::Level CGOptLevel = CodeGenOpt::Default;
diff --git a/llvm/lib/LTO/LTOBackend.cpp b/llvm/lib/LTO/LTOBackend.cpp
--- a/llvm/lib/LTO/LTOBackend.cpp
+++ b/llvm/lib/LTO/LTOBackend.cpp
@@ -324,6 +324,9 @@
   PB.registerLoopAnalyses(LAM);
   PB.crossRegisterProxies(LAM, FAM, CGAM, MAM);
 
+  if (Conf.OptPassBuilderHook)
+    Conf.OptPassBuilderHook(PB);
+
   ModulePassManager MPM;
 
   // Always verify the input.