diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -3746,6 +3746,12 @@
                                ArgStringList &CmdArgs,
                                codegenoptions::DebugInfoKind &DebugInfoKind,
                                DwarfFissionKind &DwarfFission) {
+  // These two forms of profiling info can't be used together.
+  if (const Arg *A1 = Args.getLastArg(options::OPT_fpseudo_probe_for_profiling))
+    if (const Arg *A2 = Args.getLastArg(options::OPT_fdebug_info_for_profiling))
+      D.Diag(diag::err_drv_argument_not_allowed_with)
+          << A1->getAsString(Args) << A2->getAsString(Args);
+
   if (Args.hasFlag(options::OPT_fdebug_info_for_profiling,
                    options::OPT_fno_debug_info_for_profiling, false) &&
       checkDebugInfoOption(
diff --git a/clang/test/CodeGen/pseudo-probe-emit.c b/clang/test/CodeGen/pseudo-probe-emit.c
--- a/clang/test/CodeGen/pseudo-probe-emit.c
+++ b/clang/test/CodeGen/pseudo-probe-emit.c
@@ -1,4 +1,4 @@
-// RUN: %clang -O2  -fexperimental-new-pass-manager -fpseudo-probe-for-profiling -g -emit-llvm -S -o - %s | FileCheck %s
+// RUN: %clang_cc1 -O2 -fno-legacy-pass-manager -fpseudo-probe-for-profiling -debug-info-kind=limited -emit-llvm -o - %s | FileCheck %s
 
 // Check the generation of pseudoprobe intrinsic call
 
diff --git a/clang/test/Driver/pseudo-probe.c b/clang/test/Driver/pseudo-probe.c
new file mode 100644
--- /dev/null
+++ b/clang/test/Driver/pseudo-probe.c
@@ -0,0 +1,7 @@
+// RUN: %clang -### -fpseudo-probe-for-profiling %s 2>&1 | FileCheck %s --check-prefix=YESPROBE
+// RUN: %clang -### -fno-pseudo-probe-for-profiling %s 2>&1 | FileCheck %s --check-prefix=NOPROBE
+// RUN: %clang -### -fpseudo-probe-for-profiling -fdebug-info-for-profiling %s 2>&1 | FileCheck %s --check-prefix=CONFLICT
+
+// YESPROBE: -fpseudo-probe-for-profiling
+// NOPROBE-NOT: -fpseudo-probe-for-profiling
+// CONFLICT: invalid argument