diff --git a/clang/lib/Frontend/DiagnosticRenderer.cpp b/clang/lib/Frontend/DiagnosticRenderer.cpp
--- a/clang/lib/Frontend/DiagnosticRenderer.cpp
+++ b/clang/lib/Frontend/DiagnosticRenderer.cpp
@@ -394,6 +394,9 @@
       }
     }
 
+    if (Begin.isInvalid() || End.isInvalid() || BeginFileID != EndFileID)
+      continue;
+
     // Do the backtracking.
     SmallVector<FileID, 4> CommonArgExpansions;
     computeCommonMacroArgExpansionFileIDs(Begin, End, SM, CommonArgExpansions);
diff --git a/clang/test/Analysis/crash-diagnostic-renderer.cpp b/clang/test/Analysis/crash-diagnostic-renderer.cpp
new file mode 100644
--- /dev/null
+++ b/clang/test/Analysis/crash-diagnostic-renderer.cpp
@@ -0,0 +1,13 @@
+// RUN: %clang_analyze_cc1 -analyzer-checker=core -verify %s
+
+// This case reproduces a problem that is shown here:
+// https://bugs.llvm.org/show_bug.cgi?id=46540
+// No assertion should happen in this case.
+
+// expected-error@13{{'b' does not refer to a type name in pseudo-destructor expression; expected the name of type 'volatile long'}}
+// expected-error@13{{expected ')'}}
+// expected-note@13{{to match this '('}}
+// expected-error@13{{reference to pseudo-destructor must be called; did you mean to call it with no arguments?}}
+// expected-error@13{{cannot initialize a variable of type 'volatile long' with an rvalue of type 'void'}}
+// expected-error@13{{expected ';' after top level declarator}}
+volatile long a ( a .~b