diff --git a/llvm/lib/Target/NVPTX/NVPTXISelLowering.h b/llvm/lib/Target/NVPTX/NVPTXISelLowering.h
--- a/llvm/lib/Target/NVPTX/NVPTXISelLowering.h
+++ b/llvm/lib/Target/NVPTX/NVPTXISelLowering.h
@@ -491,7 +491,8 @@
 
   std::string getPrototype(const DataLayout &DL, Type *, const ArgListTy &,
                            const SmallVectorImpl<ISD::OutputArg> &,
-                           MaybeAlign retAlignment, const CallBase &CB) const;
+                           MaybeAlign retAlignment, const CallBase &CB,
+                           const unsigned &UniqueCallSite) const;
 
   SDValue LowerReturn(SDValue Chain, CallingConv::ID CallConv, bool isVarArg,
                       const SmallVectorImpl<ISD::OutputArg> &Outs,
diff --git a/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp b/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
--- a/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
+++ b/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
@@ -65,7 +65,7 @@
 
 using namespace llvm;
 
-static unsigned int uniqueCallSite = 0;
+static std::atomic<unsigned> GlobalUniqueCallSite = ATOMIC_VAR_INIT(0);
 
 static cl::opt<bool> sched4reg(
     "nvptx-sched4reg",
@@ -1243,7 +1243,7 @@
 std::string NVPTXTargetLowering::getPrototype(
     const DataLayout &DL, Type *retTy, const ArgListTy &Args,
     const SmallVectorImpl<ISD::OutputArg> &Outs, MaybeAlign retAlignment,
-    const CallBase &CB) const {
+    const CallBase &CB, const unsigned &UniqueCallSite) const {
   auto PtrVT = getPointerTy(DL);
 
   bool isABI = (STI.getSmVersion() >= 20);
@@ -1252,7 +1252,7 @@
     return "";
 
   std::stringstream O;
-  O << "prototype_" << uniqueCallSite << " : .callprototype ";
+  O << "prototype_" << UniqueCallSite << " : .callprototype ";
 
   if (retTy->getTypeID() == Type::VoidTyID) {
     O << "()";
@@ -1422,8 +1422,9 @@
   if (!isABI)
     return Chain;
 
+  unsigned UniqueCallSite = GlobalUniqueCallSite.fetch_add(1);
   SDValue tempChain = Chain;
-  Chain = DAG.getCALLSEQ_START(Chain, uniqueCallSite, 0, dl);
+  Chain = DAG.getCALLSEQ_START(Chain, UniqueCallSite, 0, dl);
   SDValue InFlag = Chain.getValue(1);
 
   unsigned paramCount = 0;
@@ -1678,7 +1679,8 @@
     // The prototype is embedded in a string and put as the operand for a
     // CallPrototype SDNode which will print out to the value of the string.
     SDVTList ProtoVTs = DAG.getVTList(MVT::Other, MVT::Glue);
-    std::string Proto = getPrototype(DL, RetTy, Args, Outs, retAlignment, *CB);
+    std::string Proto =
+        getPrototype(DL, RetTy, Args, Outs, retAlignment, *CB, UniqueCallSite);
     const char *ProtoStr =
       nvTM->getManagedStrPool()->getManagedString(Proto.c_str())->c_str();
     SDValue ProtoOps[] = {
@@ -1734,9 +1736,8 @@
 
   if (isIndirectCall) {
     SDVTList PrototypeVTs = DAG.getVTList(MVT::Other, MVT::Glue);
-    SDValue PrototypeOps[] = { Chain,
-                               DAG.getConstant(uniqueCallSite, dl, MVT::i32),
-                               InFlag };
+    SDValue PrototypeOps[] = {
+        Chain, DAG.getConstant(UniqueCallSite, dl, MVT::i32), InFlag};
     Chain = DAG.getNode(NVPTXISD::Prototype, dl, PrototypeVTs, PrototypeOps);
     InFlag = Chain.getValue(1);
   }
@@ -1832,13 +1833,10 @@
     }
   }
 
-  Chain = DAG.getCALLSEQ_END(Chain,
-                             DAG.getIntPtrConstant(uniqueCallSite, dl, true),
-                             DAG.getIntPtrConstant(uniqueCallSite + 1, dl,
-                                                   true),
-                             InFlag, dl);
+  Chain = DAG.getCALLSEQ_END(
+      Chain, DAG.getIntPtrConstant(UniqueCallSite, dl, true),
+      DAG.getIntPtrConstant(UniqueCallSite + 1, dl, true), InFlag, dl);
   InFlag = Chain.getValue(1);
-  uniqueCallSite++;
 
   // Append ProxyReg instructions to the chain to make sure that `callseq_end`
   // will not get lost. Otherwise, during libcalls expansion, the nodes can become