diff --git a/openmp/CMakeLists.txt b/openmp/CMakeLists.txt
--- a/openmp/CMakeLists.txt
+++ b/openmp/CMakeLists.txt
@@ -39,6 +39,8 @@
     set(OPENMP_TEST_C_COMPILER ${LLVM_RUNTIME_OUTPUT_INTDIR}/clang.exe)
     set(OPENMP_TEST_CXX_COMPILER ${LLVM_RUNTIME_OUTPUT_INTDIR}/clang++.exe)
   endif()
+
+  list(APPEND LIBOMPTARGET_LLVM_INCLUDE_DIRS ${LLVM_MAIN_INCLUDE_DIR} ${LLVM_BINARY_DIR}/include)
 endif()
 
 # Check and set up common compiler flags.
@@ -67,16 +69,16 @@
 endif()
 
 # Attempt to locate LLVM source, required by libomptarget
-if (NOT LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR)
+if (NOT LIBOMPTARGET_LLVM_INCLUDE_DIRS)
   if (LLVM_MAIN_INCLUDE_DIR)
-    set(LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR ${LLVM_MAIN_INCLUDE_DIR})
+    list(APPEND LIBOMPTARGET_LLVM_INCLUDE_DIRS ${LLVM_MAIN_INCLUDE_DIR})
   elseif (EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/../llvm/include)
-    set(LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR ${CMAKE_CURRENT_SOURCE_DIR}/../llvm/include)
+    list(APPENDset LIBOMPTARGET_LLVM_INCLUDE_DIRS ${CMAKE_CURRENT_SOURCE_DIR}/../llvm/include)
   endif()
 endif()
 
-if (NOT LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR)
-  message(STATUS "Missing definition for LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR, disabling libomptarget")
+if (NOT LIBOMPTARGET_LLVM_INCLUDE_DIRS)
+  message(STATUS "Missing definition for LIBOMPTARGET_LLVM_INCLUDE_DIRS, disabling libomptarget")
   set(ENABLE_LIBOMPTARGET OFF)
 endif()
 
diff --git a/openmp/libomptarget/CMakeLists.txt b/openmp/libomptarget/CMakeLists.txt
--- a/openmp/libomptarget/CMakeLists.txt
+++ b/openmp/libomptarget/CMakeLists.txt
@@ -31,8 +31,8 @@
 include(LibomptargetGetDependencies)
 
 # LLVM source tree is required at build time for libomptarget
-if (NOT LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR)
-  message(FATAL_ERROR "Missing definition for LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR")
+if (NOT LIBOMPTARGET_LLVM_INCLUDE_DIRS)
+  message(FATAL_ERROR "Missing definition for LIBOMPTARGET_LLVM_INCLUDE_DIRS")
 endif()
 
 # This is a list of all the targets that are supported/tested right now.
diff --git a/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt b/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
--- a/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
+++ b/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
@@ -30,8 +30,8 @@
   return()
 endif()
 
-if (NOT LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR)
-  libomptarget_say("Not building AMDGPU plugin: Missing definition for LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR")
+if (NOT LIBOMPTARGET_LLVM_INCLUDE_DIRS)
+  libomptarget_say("Not building AMDGPU plugin: Missing definition for LIBOMPTARGET_LLVM_INCLUDE_DIRS")
   return()
 endif()
 
@@ -50,7 +50,7 @@
 
 include_directories(
   ${CMAKE_CURRENT_SOURCE_DIR}/impl
-  ${LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR}
+  ${LIBOMPTARGET_LLVM_INCLUDE_DIRS}
 )
 
 add_library(omptarget.rtl.amdgpu SHARED
diff --git a/openmp/libomptarget/src/CMakeLists.txt b/openmp/libomptarget/src/CMakeLists.txt
--- a/openmp/libomptarget/src/CMakeLists.txt
+++ b/openmp/libomptarget/src/CMakeLists.txt
@@ -20,7 +20,7 @@
   ${CMAKE_CURRENT_SOURCE_DIR}/omptarget.cpp
 )
 
-include_directories(${LIBOMPTARGET_LLVM_MAIN_INCLUDE_DIR})
+include_directories(${LIBOMPTARGET_LLVM_INCLUDE_DIRS})
 
 # Build libomptarget library with libdl dependency. Add LLVMSupport
 # dependency if building in-tree with profiling enabled.