diff --git a/.gitignore b/.gitignore
--- a/.gitignore
+++ b/.gitignore
@@ -63,3 +63,5 @@
 /clang/utils/analyzer/projects/*/PatchedSource
 /clang/utils/analyzer/projects/*/ScanBuildResults
 /clang/utils/analyzer/projects/*/RefScanBuildResults
+# automodapi puts generated documentation files here.
+/lldb/docs/python_api/
diff --git a/lldb/docs/CMakeLists.txt b/lldb/docs/CMakeLists.txt
--- a/lldb/docs/CMakeLists.txt
+++ b/lldb/docs/CMakeLists.txt
@@ -15,60 +15,39 @@
   )
 endif()
 
-if (LLDB_ENABLE_PYTHON)
-  find_program(EPYDOC_EXECUTABLE NAMES epydoc epydoc.py)
-  if(EPYDOC_EXECUTABLE)
-    message(STATUS "Found epydoc - ${EPYDOC_EXECUTABLE}")
-
-    find_program(DOT_EXECUTABLE dot)
-    if(DOT_EXECUTABLE)
-      set(EPYDOC_OPTIONS ${EPYDOC_OPTIONS} --graph all --dotpath ${DOT_EXECUTABLE})
-      message(STATUS "Found dot - ${DOT_EXECUTABLE}")
-    endif()
+if (LLVM_ENABLE_SPHINX)
+  include(AddSphinxTarget)
+endif()
 
-    # Pretend to make a python package so that we can generate the reference.
-    # Because we don't build liblldb, epydoc will complain that the import of
-    # _lldb.so failed, but that doesn't prevent it from generating the docs.
+if (LLDB_ENABLE_PYTHON AND SPHINX_FOUND)
+  if (${SPHINX_OUTPUT_HTML})
+    # Pretend that the SWIG generated API is a Python package.
     file(MAKE_DIRECTORY ${CMAKE_CURRENT_BINARY_DIR}/lldb)
     get_target_property(lldb_bindings_dir swig_wrapper_python BINARY_DIR)
     add_custom_target(lldb-python-doc-package
       COMMAND "${CMAKE_COMMAND}" -E copy "${lldb_bindings_dir}/lldb.py" "${CMAKE_CURRENT_BINARY_DIR}/lldb/__init__.py"
-      COMMENT "Copying lldb.py to pretend package.")
+      COMMENT "Copying lldb.py to pretend its a Python package.")
     add_dependencies(lldb-python-doc-package swig_wrapper_python)
 
-    set(DOC_DIR "${CMAKE_CURRENT_SOURCE_DIR}/doc")
-    file(MAKE_DIRECTORY "${DOC_DIR}")
-    add_custom_target(lldb-python-doc
-      ${EPYDOC_EXECUTABLE}
-      --html
-      lldb
-      -o ${CMAKE_CURRENT_BINARY_DIR}/python_reference
-      --name "LLDB python API"
-      --url "http://lldb.llvm.org"
-      ${EPYDOC_OPTIONS}
-      WORKING_DIRECTORY ${CMAKE_CURRENT_BINARY_DIR}
-      COMMENT "Generating LLDB Python API reference with epydoc" VERBATIM
-    )
-    add_dependencies(lldb-python-doc swig_wrapper_python lldb-python-doc-package)
-  else()
-    message(STATUS "Could NOT find epydoc")
+    # FIXME: Don't treat Sphinx warnings as errors. The files generated by
+    # automodapi are full of warnings (partly caused by SWIG, our documentation
+    # and probably also automodapi itself), so those warnings need to be fixed
+    # first before we can turn this on.
+    set(SPHINX_WARNINGS_AS_ERRORS Off)
+
+    # The sphinx config needs to know where the generated LLDB Python module is.
+    # There is no way to pass a variable into our sphinx config, so just pass
+    # the path to the module via the LLDB_SWIG_MODULE environment variable.
+    add_sphinx_target(html lldb ENV_VARS "LLDB_SWIG_MODULE=${CMAKE_CURRENT_BINARY_DIR}")
+    # Sphinx does not reliably update the custom CSS files, so force
+    # a clean rebuild of the documentation every time.
+    add_custom_target(clean-lldb-html COMMAND "${CMAKE_COMMAND}" -E
+      remove_directory ${CMAKE_CURRENT_BINARY_DIR}/html)
+    add_dependencies(docs-lldb-html swig_wrapper_python
+                     lldb-python-doc-package clean-lldb-html)
   endif()
-endif ()
-
-if (LLVM_ENABLE_SPHINX)
-  include(AddSphinxTarget)
-  if (SPHINX_FOUND)
-    if (${SPHINX_OUTPUT_HTML})
-      add_sphinx_target(html lldb)
-      # Sphinx does not reliably update the custom CSS files, so force
-      # a clean rebuild of the documentation every time.
-      add_custom_target(clean-lldb-html COMMAND "${CMAKE_COMMAND}" -E
-        remove_directory ${CMAKE_CURRENT_BINARY_DIR}/html)
-      add_dependencies(docs-lldb-html clean-lldb-html)
-    endif()
 
-    if (${SPHINX_OUTPUT_MAN})
-      add_sphinx_target(man lldb)
-    endif()
+  if (${SPHINX_OUTPUT_MAN})
+    add_sphinx_target(man lldb)
   endif()
 endif()
diff --git a/lldb/docs/_lldb/__init__.py b/lldb/docs/_lldb/__init__.py
new file mode 100644
--- /dev/null
+++ b/lldb/docs/_lldb/__init__.py
@@ -0,0 +1,9 @@
+from unittest.mock import Mock
+import sys
+import types
+
+# This package acts as a mock implementation of the native _lldb module so
+# that generating the LLDB documentation doesn't actually require building all
+# of LLDB.
+module_name = '_lldb'
+sys.modules[module_name] = Mock()
diff --git a/lldb/docs/conf.py b/lldb/docs/conf.py
--- a/lldb/docs/conf.py
+++ b/lldb/docs/conf.py
@@ -18,7 +18,17 @@
 # If extensions (or modules to document with autodoc) are in another directory,
 # add these directories to sys.path here. If the directory is relative to the
 # documentation root, use os.path.abspath to make it absolute, like shown here.
-#sys.path.insert(0, os.path.abspath('.'))
+
+# Add the current directory that contains the mock _lldb native module which
+# is imported by the `lldb` module.
+sys.path.insert(0, os.path.abspath("."))
+# Add the build directory that contains the `lldb` module. LLDB_SWIG_MODULE is
+# set by CMake.
+sys.path.insert(0, os.getenv("LLDB_SWIG_MODULE"))
+
+# Put the generated Python API documentation in the 'python_api' folder. This
+# also defines the URL these files will have in the generated website.
+automodapi_toctreedirnm = 'python_api'
 
 # -- General configuration -----------------------------------------------------
 
@@ -27,7 +37,8 @@
 
 # Add any Sphinx extension module names here, as strings. They can be extensions
 # coming with Sphinx (named 'sphinx.ext.*') or your custom ones.
-extensions = ['sphinx.ext.todo', 'sphinx.ext.mathjax', 'sphinx.ext.intersphinx']
+extensions = ['sphinx.ext.todo', 'sphinx.ext.mathjax', 'sphinx.ext.intersphinx',
+              'sphinx_automodapi.automodapi']
 
 # Add any paths that contain templates here, relative to this directory.
 templates_path = ['_templates']
diff --git a/lldb/docs/index.rst b/lldb/docs/index.rst
--- a/lldb/docs/index.rst
+++ b/lldb/docs/index.rst
@@ -164,7 +164,7 @@
    :maxdepth: 1
    :caption: Reference
 
-   Public Python API <https://lldb.llvm.org/python_reference/index.html>
+   Public Python API <python_api>
    Public C++ API <https://lldb.llvm.org/cpp_reference/namespacelldb.html>
    Private C++ API <https://lldb.llvm.org/cpp_reference/index.html>
    Man Page <man/lldb>
diff --git a/lldb/docs/python_api.rst b/lldb/docs/python_api.rst
new file mode 100644
--- /dev/null
+++ b/lldb/docs/python_api.rst
@@ -0,0 +1,98 @@
+LLDB Python API
+================================
+
+..
+  The long list of "skip" filters out several global functions that are
+  generated by SWIG (but which are not useful as they are only the
+  backend for their respective static functions in the classes).
+  Without this list
+.. automodapi:: lldb
+  :no-inheritance-diagram:
+  :skip: SBBreakpoint_EventIsBreakpointEvent
+  :skip: SBBreakpoint_GetBreakpointEventTypeFromEvent
+  :skip: SBBreakpoint_GetBreakpointFromEvent
+  :skip: SBBreakpoint_GetBreakpointLocationAtIndexFromEvent
+  :skip: SBBreakpoint_GetNumBreakpointLocationsFromEvent
+  :skip: SBCommandInterpreter_EventIsCommandInterpreterEvent
+  :skip: SBCommandInterpreter_GetArgumentDescriptionAsCString
+  :skip: SBCommandInterpreter_GetArgumentTypeAsCString
+  :skip: SBCommandInterpreter_GetBroadcasterClass
+  :skip: SBCommunication_GetBroadcasterClass
+  :skip: SBData_CreateDataFromCString
+  :skip: SBData_CreateDataFromDoubleArray
+  :skip: SBData_CreateDataFromSInt32Array
+  :skip: SBData_CreateDataFromSInt64Array
+  :skip: SBData_CreateDataFromUInt32Array
+  :skip: SBData_CreateDataFromUInt64Array
+  :skip: SBDebugger_Create
+  :skip: SBDebugger_Create
+  :skip: SBDebugger_Destroy
+  :skip: SBDebugger_FindDebuggerWithID
+  :skip: SBDebugger_GetBuildConfiguration
+  :skip: SBDebugger_GetDefaultArchitecture
+  :skip: SBDebugger_GetInternalVariableValue
+  :skip: SBDebugger_GetVersionString
+  :skip: SBDebugger_Initialize
+  :skip: SBDebugger_InitializeWithErrorHandling
+  :skip: SBDebugger_MemoryPressureDetected
+  :skip: SBDebugger_SetDefaultArchitecture
+  :skip: SBDebugger_SetInternalVariable
+  :skip: SBDebugger_StateAsCString
+  :skip: SBDebugger_StateIsRunningState
+  :skip: SBDebugger_StateIsStoppedState
+  :skip: SBDebugger_Terminate
+  :skip: SBEvent_GetCStringFromEvent
+  :skip: SBFileSpec_ResolvePath
+  :skip: SBFile_MakeBorrowed
+  :skip: SBFile_MakeBorrowedForcingIOMethods
+  :skip: SBFile_MakeForcingIOMethods
+  :skip: SBHostOS_GetLLDBPath
+  :skip: SBHostOS_GetLLDBPythonPath
+  :skip: SBHostOS_GetProgramFileSpec
+  :skip: SBHostOS_GetUserHomeDirectory
+  :skip: SBHostOS_ThreadCancel
+  :skip: SBHostOS_ThreadCreate
+  :skip: SBHostOS_ThreadCreated
+  :skip: SBHostOS_ThreadDetach
+  :skip: SBHostOS_ThreadJoin
+  :skip: SBLanguageRuntime_GetLanguageTypeFromString
+  :skip: SBLanguageRuntime_GetNameForLanguageType
+  :skip: SBModuleSpecList_GetModuleSpecifications
+  :skip: SBModule_GarbageCollectAllocatedModules
+  :skip: SBModule_GetNumberAllocatedModules
+  :skip: SBPlatform_GetHostPlatform
+  :skip: SBProcess_EventIsProcessEvent
+  :skip: SBProcess_EventIsStructuredDataEvent
+  :skip: SBProcess_GetBroadcasterClassName
+  :skip: SBProcess_GetInterruptedFromEvent
+  :skip: SBProcess_GetNumRestartedReasonsFromEvent
+  :skip: SBProcess_GetProcessFromEvent
+  :skip: SBProcess_GetRestartedFromEvent
+  :skip: SBProcess_GetRestartedReasonAtIndexFromEvent
+  :skip: SBProcess_GetStateFromEvent
+  :skip: SBProcess_GetStructuredDataFromEvent
+  :skip: SBReproducer_Capture
+  :skip: SBReproducer_PassiveReplay
+  :skip: SBReproducer_SetAutoGenerate
+  :skip: SBReproducer_SetWorkingDirectory
+  :skip: SBTarget_EventIsTargetEvent
+  :skip: SBTarget_GetBroadcasterClassName
+  :skip: SBTarget_GetModuleAtIndexFromEvent
+  :skip: SBTarget_GetNumModulesFromEvent
+  :skip: SBTarget_GetTargetFromEvent
+  :skip: SBThread_EventIsThreadEvent
+  :skip: SBThread_GetBroadcasterClassName
+  :skip: SBThread_GetStackFrameFromEvent
+  :skip: SBThread_GetThreadFromEvent
+  :skip: SBTypeSummary_CreateWithFunctionName
+  :skip: SBTypeSummary_CreateWithScriptCode
+  :skip: SBTypeSummary_CreateWithSummaryString
+  :skip: SBTypeSynthetic_CreateWithClassName
+  :skip: SBTypeSynthetic_CreateWithScriptCode
+  :skip: SBWatchpoint_EventIsWatchpointEvent
+  :skip: SBWatchpoint_GetWatchpointEventTypeFromEvent
+  :skip: SBWatchpoint_GetWatchpointFromEvent
+  :skip: command
+  :skip: in_range
+  :skip: is_numeric_type
+  :skip: lldb_iter
diff --git a/llvm/cmake/modules/AddSphinxTarget.cmake b/llvm/cmake/modules/AddSphinxTarget.cmake
--- a/llvm/cmake/modules/AddSphinxTarget.cmake
+++ b/llvm/cmake/modules/AddSphinxTarget.cmake
@@ -17,8 +17,13 @@
 # the sphinx-build command.
 #
 # ``project`` should be the project name
+#
+# Named arguments:
+# ``ENV_VARS`` should be a list of environment variables that should be set when
+#              running Sphinx. Each environment variable should be a string with
+#              the form KEY=VALUE.
 function (add_sphinx_target builder project)
-  cmake_parse_arguments(ARG "" "SOURCE_DIR" "" ${ARGN})
+  cmake_parse_arguments(ARG "" "SOURCE_DIR" "ENV_VARS" ${ARGN})
   set(SPHINX_BUILD_DIR "${CMAKE_CURRENT_BINARY_DIR}/${builder}")
   set(SPHINX_DOC_TREE_DIR "${CMAKE_CURRENT_BINARY_DIR}/_doctrees-${project}-${builder}")
   set(SPHINX_TARGET_NAME docs-${project}-${builder})
@@ -34,7 +39,8 @@
   endif()
 
   add_custom_target(${SPHINX_TARGET_NAME}
-                    COMMAND ${SPHINX_EXECUTABLE}
+                    COMMAND ${CMAKE_COMMAND} -E env ${ARG_ENV_VARS}
+                            ${SPHINX_EXECUTABLE}
                             -b ${builder}
                             -d "${SPHINX_DOC_TREE_DIR}"
                             -q # Quiet: no output other than errors and warnings.