diff --git a/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp b/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp
@@ -589,7 +589,15 @@
   // Fold away bit casts of the loaded value by loading the desired type.
   // Note that we should not do this for pointer<->integer casts,
   // because that would result in type punning.
-  if (LI.hasOneUse())
+  if (LI.hasOneUse()) {
+    // Don't transform when the type is x86_amx, it make the pass that lower
+    // x86_amx type happy.
+    if (auto *BC = dyn_cast<BitCastInst>(LI.user_back())) {
+      Value *V = BC->getOperand(0);
+      if (BC->getType()->isX86_AMXTy() || V->getType()->isX86_AMXTy())
+        return nullptr;
+    }
+
     if (auto* CI = dyn_cast<CastInst>(LI.user_back()))
       if (CI->isNoopCast(DL) && LI.getType()->isPtrOrPtrVectorTy() ==
                                     CI->getDestTy()->isPtrOrPtrVectorTy())
@@ -599,6 +607,7 @@
           IC.eraseInstFromFunction(*CI);
           return &LI;
         }
+  }
 
   // FIXME: We should also canonicalize loads of vectors when their elements are
   // cast to other types.
diff --git a/llvm/test/Transforms/InstCombine/load.ll b/llvm/test/Transforms/InstCombine/load.ll
--- a/llvm/test/Transforms/InstCombine/load.ll
+++ b/llvm/test/Transforms/InstCombine/load.ll
@@ -422,3 +422,35 @@
   call void @use.v2.p1(<2 x i8 addrspace(1)*> %Y)
   ret <2 x i64> %X
 }
+
+; Prohibit poiter cast for amx.
+define dso_local void @test_amx_load_store(<256 x i32>* %src, x86_amx* %dst) {
+; CHECK-LABEL: @test_amx_load_store(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    [[VEC:%.*]] = load <256 x i32>, <256 x i32>* [[SRC:%.*]], align 64
+; CHECK-NEXT:    [[BC:%.*]] = bitcast <256 x i32> [[VEC]] to x86_amx
+; CHECK-NEXT:    store x86_amx [[BC]], x86_amx* [[DST:%.*]], align 64
+; CHECK-NEXT:    ret void
+;
+entry:
+  %vec = load <256 x i32>, <256 x i32>* %src, align 64
+  %bc = bitcast <256 x i32> %vec to x86_amx
+  store x86_amx %bc, x86_amx* %dst
+  ret void
+}
+
+; Prohibit poiter cast for amx.
+define dso_local void @test_amx_load_store2(<256 x i32>* %dst, x86_amx* %src) {
+; CHECK-LABEL: @test_amx_load_store2(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    [[VEC:%.*]] = load x86_amx, x86_amx* [[SRC:%.*]], align 64
+; CHECK-NEXT:    [[BC:%.*]] = bitcast x86_amx [[VEC]] to <256 x i32>
+; CHECK-NEXT:    store <256 x i32> [[BC]], <256 x i32>* [[DST:%.*]], align 1024
+; CHECK-NEXT:    ret void
+;
+entry:
+  %vec = load x86_amx, x86_amx* %src, align 64
+  %bc = bitcast x86_amx %vec to <256 x i32>
+  store <256 x i32> %bc, <256 x i32>* %dst
+  ret void
+}