diff --git a/llvm/include/llvm/Passes/PassBuilder.h b/llvm/include/llvm/Passes/PassBuilder.h
--- a/llvm/include/llvm/Passes/PassBuilder.h
+++ b/llvm/include/llvm/Passes/PassBuilder.h
@@ -460,6 +460,9 @@
 
   /// Build the default `AAManager` with the default alias analysis pipeline
   /// registered.
+  ///
+  /// This also adds target-specific alias analyses registered via
+  /// TargetMachine::registerAliasAnalyses().
   AAManager buildDefaultAAPipeline();
 
   /// Parse a textual pass pipeline description into a \c
diff --git a/llvm/include/llvm/Target/TargetMachine.h b/llvm/include/llvm/Target/TargetMachine.h
--- a/llvm/include/llvm/Target/TargetMachine.h
+++ b/llvm/include/llvm/Target/TargetMachine.h
@@ -23,6 +23,7 @@
 
 namespace llvm {
 
+class AAManager;
 class Function;
 class GlobalValue;
 class MachineModuleInfoWrapperPass;
@@ -322,6 +323,10 @@
   virtual void registerPassBuilderCallbacks(PassBuilder &,
                                             bool DebugPassManager) {}
 
+  /// Allow the target to register alias analyses with the AAManager for use
+  /// with the new pass manager. Only affects the "default" AAManager.
+  virtual void registerAliasAnalyses(AAManager &) {}
+
   /// Add passes to the specified pass manager to get the specified file
   /// emitted.  Typically this will involve several steps of code generation.
   /// This method should return true if emission of this file type is not
diff --git a/llvm/lib/Passes/PassBuilder.cpp b/llvm/lib/Passes/PassBuilder.cpp
--- a/llvm/lib/Passes/PassBuilder.cpp
+++ b/llvm/lib/Passes/PassBuilder.cpp
@@ -1882,6 +1882,10 @@
   // results from `GlobalsAA` through a readonly proxy.
   AA.registerModuleAnalysis<GlobalsAA>();
 
+  // Add target-specific alias analyses.
+  if (TM)
+    TM->registerAliasAnalyses(AA);
+
   return AA;
 }