diff --git a/llvm/lib/Transforms/Instrumentation/IndirectCallPromotion.cpp b/llvm/lib/Transforms/Instrumentation/IndirectCallPromotion.cpp
--- a/llvm/lib/Transforms/Instrumentation/IndirectCallPromotion.cpp
+++ b/llvm/lib/Transforms/Instrumentation/IndirectCallPromotion.cpp
@@ -263,8 +263,15 @@
       break;
     }
 
+    // Don't promote if the symbol is not defined in the module. This avoids
+    // creating a reference to a symbol that doesn't exist in the module
+    // This can happen when we compile with a sample profile collected from
+    // one binary but used for another, which may have profiled targets that
+    // aren't used in the new binary. We might have a declaration initially in
+    // the case where the symbol is globally dead in the binary and removed by
+    // ThinLTO.
     Function *TargetFunction = Symtab->getFunction(Target);
-    if (TargetFunction == nullptr) {
+    if (TargetFunction == nullptr || TargetFunction->isDeclaration()) {
       LLVM_DEBUG(dbgs() << " Not promote: Cannot find the target\n");
       ORE.emit([&]() {
         return OptimizationRemarkMissed(DEBUG_TYPE, "UnableToFindTarget", &CB)
diff --git a/llvm/test/LTO/Resolution/X86/load-sample-prof-icp.ll b/llvm/test/LTO/Resolution/X86/load-sample-prof-icp.ll
--- a/llvm/test/LTO/Resolution/X86/load-sample-prof-icp.ll
+++ b/llvm/test/LTO/Resolution/X86/load-sample-prof-icp.ll
@@ -3,11 +3,11 @@
 ;
 ; RUN: opt -module-summary < %s -o %t.bc
 ; RUN: llvm-lto2 run -o %t.out %t.bc -save-temps \
-; RUN:   -r %t.bc,test,px -r %t.bc,bar,x \
+; RUN:   -r %t.bc,test,px -r %t.bc,bar,px -r %t.bc,externfunc,x \
 ; RUN:   -lto-sample-profile-file=%S/Inputs/load-sample-prof-icp.prof
 ; RUN: llvm-dis %t.out.1.4.opt.bc -o - | FileCheck %s
 ; RUN: llvm-lto2 run -o %t.out %t.bc -save-temps \
-; RUN:   -r %t.bc,test,px -r %t.bc,bar,x -use-new-pm \
+; RUN:   -r %t.bc,test,px -r %t.bc,bar,px -r %t.bc,externfunc,x -use-new-pm \
 ; RUN:   -lto-sample-profile-file=%S/Inputs/load-sample-prof-icp.prof
 ; RUN: llvm-dis %t.out.1.4.opt.bc -o - | FileCheck %s
 
@@ -26,9 +26,14 @@
   ret void
 }
 
-declare void @bar() local_unnamed_addr
+declare void @externfunc()
 
-attributes #0 = {"use-sample-profile"}
+define void @bar() #0 {
+  call void @externfunc()
+  ret void
+}
+
+attributes #0 = {"use-sample-profile" noinline}
 
 !llvm.dbg.cu = !{!0}
 !llvm.module.flags = !{!3, !4, !5}
diff --git a/llvm/test/Transforms/PGOProfile/icp_covariant_call_return.ll b/llvm/test/Transforms/PGOProfile/icp_covariant_call_return.ll
--- a/llvm/test/Transforms/PGOProfile/icp_covariant_call_return.ll
+++ b/llvm/test/Transforms/PGOProfile/icp_covariant_call_return.ll
@@ -10,7 +10,9 @@
 
 declare noalias i8* @_Znwm(i64)
 declare void @_ZN1DC2Ev(%struct.D*);
-declare %struct.Derived* @_ZN1D4funcEv(%struct.D*);
+define %struct.Derived* @_ZN1D4funcEv(%struct.D*) {
+  ret %struct.Derived* null
+}
 
 define %struct.Base* @bar() {
 entry:
diff --git a/llvm/test/Transforms/PGOProfile/icp_covariant_invoke_return.ll b/llvm/test/Transforms/PGOProfile/icp_covariant_invoke_return.ll
--- a/llvm/test/Transforms/PGOProfile/icp_covariant_invoke_return.ll
+++ b/llvm/test/Transforms/PGOProfile/icp_covariant_invoke_return.ll
@@ -10,7 +10,9 @@
 @_ZTIi = external constant i8*
 declare i8* @_Znwm(i64)
 declare void @_ZN1DC2Ev(%struct.D*)
-declare %struct.Derived* @_ZN1D4funcEv(%struct.D*)
+define %struct.Derived* @_ZN1D4funcEv(%struct.D*) {
+  ret %struct.Derived* null
+}
 declare void @_ZN1DD0Ev(%struct.D*)
 declare void @_ZdlPv(i8*)
 declare i32 @__gxx_personality_v0(...)
diff --git a/llvm/test/Transforms/PGOProfile/indirect_call_promotion_musttail.ll b/llvm/test/Transforms/PGOProfile/indirect_call_promotion_musttail.ll
--- a/llvm/test/Transforms/PGOProfile/indirect_call_promotion_musttail.ll
+++ b/llvm/test/Transforms/PGOProfile/indirect_call_promotion_musttail.ll
@@ -6,13 +6,21 @@
 
 @foo = common global i32* ()* null, align 8
 
-declare i32* @func1()
+define i32* @func1() {
+  ret i32* null
+}
 
-declare i32* @func2()
+define i32* @func2() {
+  ret i32* null
+}
 
-declare i32* @func3()
+define i32* @func3() {
+  ret i32* null
+}
 
-declare i32* @func4()
+define i32* @func4() {
+  ret i32* null
+}
 
 define i32* @bar() {
 entry: