diff --git a/llvm/include/llvm/Analysis/TargetTransformInfo.h b/llvm/include/llvm/Analysis/TargetTransformInfo.h
--- a/llvm/include/llvm/Analysis/TargetTransformInfo.h
+++ b/llvm/include/llvm/Analysis/TargetTransformInfo.h
@@ -613,6 +613,11 @@
   bool isLSRCostLess(TargetTransformInfo::LSRCost &C1,
                      TargetTransformInfo::LSRCost &C2) const;
 
+  /// Return true if LSR major cost is register number. Targets which implement
+  /// their own isLSRCostLess and unset register number as major cost should
+  /// return false, otherwise return true.
+  bool isRegNumMajorCostOfLSR() const;
+
   /// \returns true if LSR should not optimize a chain that includes \p I.
   bool isProfitableLSRChainElement(Instruction *I) const;
 
@@ -1410,6 +1415,7 @@
                                      Instruction *I) = 0;
   virtual bool isLSRCostLess(TargetTransformInfo::LSRCost &C1,
                              TargetTransformInfo::LSRCost &C2) = 0;
+  virtual bool isRegNumMajorCostOfLSR() = 0;
   virtual bool isProfitableLSRChainElement(Instruction *I) = 0;
   virtual bool canMacroFuseCmp() = 0;
   virtual bool canSaveCmp(Loop *L, BranchInst **BI, ScalarEvolution *SE,
@@ -1731,6 +1737,9 @@
                      TargetTransformInfo::LSRCost &C2) override {
     return Impl.isLSRCostLess(C1, C2);
   }
+  bool isRegNumMajorCostOfLSR() override {
+    return Impl.isRegNumMajorCostOfLSR();
+  }
   bool isProfitableLSRChainElement(Instruction *I) override {
     return Impl.isProfitableLSRChainElement(I);
   }
diff --git a/llvm/include/llvm/Analysis/TargetTransformInfoImpl.h b/llvm/include/llvm/Analysis/TargetTransformInfoImpl.h
--- a/llvm/include/llvm/Analysis/TargetTransformInfoImpl.h
+++ b/llvm/include/llvm/Analysis/TargetTransformInfoImpl.h
@@ -192,6 +192,8 @@
                     C2.ScaleCost, C2.ImmCost, C2.SetupCost);
   }
 
+  bool isRegNumMajorCostOfLSR() { return true; }
+
   bool isProfitableLSRChainElement(Instruction *I) { return false; }
 
   bool canMacroFuseCmp() { return false; }
diff --git a/llvm/include/llvm/CodeGen/BasicTTIImpl.h b/llvm/include/llvm/CodeGen/BasicTTIImpl.h
--- a/llvm/include/llvm/CodeGen/BasicTTIImpl.h
+++ b/llvm/include/llvm/CodeGen/BasicTTIImpl.h
@@ -264,6 +264,10 @@
     return TargetTransformInfoImplBase::isLSRCostLess(C1, C2);
   }
 
+  bool isRegNumMajorCostOfLSR() {
+    return TargetTransformInfoImplBase::isRegNumMajorCostOfLSR();
+  }
+
   bool isProfitableLSRChainElement(Instruction *I) {
     return TargetTransformInfoImplBase::isProfitableLSRChainElement(I);
   }
diff --git a/llvm/lib/Analysis/TargetTransformInfo.cpp b/llvm/lib/Analysis/TargetTransformInfo.cpp
--- a/llvm/lib/Analysis/TargetTransformInfo.cpp
+++ b/llvm/lib/Analysis/TargetTransformInfo.cpp
@@ -377,6 +377,10 @@
   return TTIImpl->isLSRCostLess(C1, C2);
 }
 
+bool TargetTransformInfo::isRegNumMajorCostOfLSR() const {
+  return TTIImpl->isRegNumMajorCostOfLSR();
+}
+
 bool TargetTransformInfo::isProfitableLSRChainElement(Instruction *I) const {
   return TTIImpl->isProfitableLSRChainElement(I);
 }
diff --git a/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.h b/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.h
--- a/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.h
+++ b/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.h
@@ -75,6 +75,7 @@
                              TTI::PeelingPreferences &PP);
   bool isLSRCostLess(TargetTransformInfo::LSRCost &C1,
                      TargetTransformInfo::LSRCost &C2);
+  bool isRegNumMajorCostOfLSR();
 
   /// @}
 
diff --git a/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.cpp b/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.cpp
--- a/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.cpp
+++ b/llvm/lib/Target/PowerPC/PPCTargetTransformInfo.cpp
@@ -1204,6 +1204,10 @@
     return TargetTransformInfoImplBase::isLSRCostLess(C1, C2);
 }
 
+bool PPCTTIImpl::isRegNumMajorCostOfLSR() {
+  return false;
+}
+
 bool PPCTTIImpl::getTgtMemIntrinsic(IntrinsicInst *Inst,
                                     MemIntrinsicInfo &Info) {
   switch (Inst->getIntrinsicID()) {
diff --git a/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp b/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp
--- a/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp
+++ b/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp
@@ -2860,13 +2860,20 @@
   unsigned NumVarIncrements = 0;
   unsigned NumReusedIncrements = 0;
 
-  if (TTI.isProfitableLSRChainElement(Chain.Incs[0].UserInst))
-    return true;
-
-  for (const IVInc &Inc : Chain) {
+  // If any LSRUse in the chain is marked as profitable by target, mark this
+  // chain as profitable.
+  for (const IVInc &Inc : Chain.Incs)
     if (TTI.isProfitableLSRChainElement(Inc.UserInst))
       return true;
 
+  // If register number is the major cost, we cannot benefit from this
+  // profitable chain which is based on register number.
+  // FIXME: add profitable chain optimization for other kinds major cost, for
+  // example instruction number.
+  if (!TTI.isRegNumMajorCostOfLSR())
+    return false;
+
+  for (const IVInc &Inc : Chain) {
     if (Inc.IncExpr->isZero())
       continue;
 
diff --git a/llvm/test/CodeGen/PowerPC/lsr-profitable-chain.ll b/llvm/test/CodeGen/PowerPC/lsr-profitable-chain.ll
--- a/llvm/test/CodeGen/PowerPC/lsr-profitable-chain.ll
+++ b/llvm/test/CodeGen/PowerPC/lsr-profitable-chain.ll
@@ -16,85 +16,90 @@
 ; CHECK-NEXT:    std 30, -16(1) # 8-byte Folded Spill
 ; CHECK-NEXT:    bge 0, .LBB0_6
 ; CHECK-NEXT:  # %bb.1: # %.preheader
-; CHECK-NEXT:    mulld 11, 8, 5
-; CHECK-NEXT:    mulld 12, 9, 8
-; CHECK-NEXT:    sldi 0, 10, 3
-; CHECK-NEXT:    sldi 11, 11, 3
-; CHECK-NEXT:    sldi 12, 12, 3
-; CHECK-NEXT:    add 11, 3, 11
+; CHECK-NEXT:    addi 30, 5, 1
+; CHECK-NEXT:    addi 29, 5, 3
+; CHECK-NEXT:    addi 28, 5, 2
+; CHECK-NEXT:    mulld 12, 8, 5
+; CHECK-NEXT:    addi 3, 3, 16
+; CHECK-NEXT:    mulld 0, 9, 8
+; CHECK-NEXT:    sldi 11, 10, 3
+; CHECK-NEXT:    mulld 30, 8, 30
+; CHECK-NEXT:    mulld 29, 8, 29
+; CHECK-NEXT:    mulld 8, 8, 28
 ; CHECK-NEXT:    b .LBB0_3
 ; CHECK-NEXT:    .p2align 4
 ; CHECK-NEXT:  .LBB0_2:
 ; CHECK-NEXT:    add 5, 5, 9
-; CHECK-NEXT:    add 11, 11, 12
+; CHECK-NEXT:    add 12, 12, 0
+; CHECK-NEXT:    add 30, 30, 0
+; CHECK-NEXT:    add 29, 29, 0
+; CHECK-NEXT:    add 8, 8, 0
 ; CHECK-NEXT:    cmpd 5, 7
 ; CHECK-NEXT:    bge 0, .LBB0_6
 ; CHECK-NEXT:  .LBB0_3: # =>This Loop Header: Depth=1
 ; CHECK-NEXT:    # Child Loop BB0_5 Depth 2
-; CHECK-NEXT:    sub 30, 5, 10
-; CHECK-NEXT:    cmpd 6, 30
+; CHECK-NEXT:    sub 28, 5, 10
+; CHECK-NEXT:    cmpd 6, 28
 ; CHECK-NEXT:    bge 0, .LBB0_2
 ; CHECK-NEXT:  # %bb.4:
-; CHECK-NEXT:    addi 28, 5, 1
-; CHECK-NEXT:    addi 27, 5, 2
-; CHECK-NEXT:    addi 26, 5, 3
-; CHECK-NEXT:    mulld 29, 5, 8
-; CHECK-NEXT:    sldi 25, 6, 3
-; CHECK-NEXT:    mulld 28, 28, 8
-; CHECK-NEXT:    mulld 27, 27, 8
-; CHECK-NEXT:    mulld 26, 26, 8
-; CHECK-NEXT:    .p2align 5
-; CHECK-NEXT:  .LBB0_5: # Parent Loop BB0_3 Depth=1
-; CHECK-NEXT:    # => This Inner Loop Header: Depth=2
-; CHECK-NEXT:    lfdx 0, 4, 25
-; CHECK-NEXT:    lfdx 1, 11, 25
+; CHECK-NEXT:    add 26, 6, 12
+; CHECK-NEXT:    add 25, 6, 30
 ; CHECK-NEXT:    add 24, 6, 29
-; CHECK-NEXT:    mr 23, 3
-; CHECK-NEXT:    xsadddp 0, 0, 1
+; CHECK-NEXT:    add 23, 6, 8
+; CHECK-NEXT:    sldi 27, 6, 3
+; CHECK-NEXT:    sldi 26, 26, 3
+; CHECK-NEXT:    sldi 25, 25, 3
 ; CHECK-NEXT:    sldi 24, 24, 3
+; CHECK-NEXT:    sldi 23, 23, 3
+; CHECK-NEXT:    add 27, 4, 27
+; CHECK-NEXT:    add 26, 3, 26
+; CHECK-NEXT:    add 25, 3, 25
 ; CHECK-NEXT:    add 24, 3, 24
-; CHECK-NEXT:    lfd 1, 8(24)
+; CHECK-NEXT:    add 23, 3, 23
+; CHECK-NEXT:    .p2align 5
+; CHECK-NEXT:  .LBB0_5: # Parent Loop BB0_3 Depth=1
+; CHECK-NEXT:    # => This Inner Loop Header: Depth=2
+; CHECK-NEXT:    lfd 0, 0(27)
+; CHECK-NEXT:    lfd 1, -16(26)
+; CHECK-NEXT:    add 6, 6, 10
+; CHECK-NEXT:    cmpd 6, 28
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 16(24)
+; CHECK-NEXT:    lfd 1, -8(26)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 24(24)
-; CHECK-NEXT:    add 24, 6, 28
-; CHECK-NEXT:    sldi 24, 24, 3
+; CHECK-NEXT:    lfd 1, 0(26)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfdux 1, 23, 24
-; CHECK-NEXT:    add 24, 6, 27
-; CHECK-NEXT:    sldi 24, 24, 3
+; CHECK-NEXT:    lfd 1, 8(26)
+; CHECK-NEXT:    add 26, 26, 11
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 8(23)
+; CHECK-NEXT:    lfd 1, -16(25)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 16(23)
+; CHECK-NEXT:    lfd 1, -8(25)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 24(23)
-; CHECK-NEXT:    mr 23, 3
-; CHECK-NEXT:    lfdux 2, 23, 24
-; CHECK-NEXT:    add 24, 6, 26
-; CHECK-NEXT:    add 6, 6, 10
-; CHECK-NEXT:    sldi 24, 24, 3
-; CHECK-NEXT:    cmpd 6, 30
+; CHECK-NEXT:    lfd 1, 0(25)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 8(23)
-; CHECK-NEXT:    xsadddp 0, 0, 2
+; CHECK-NEXT:    lfd 1, 8(25)
+; CHECK-NEXT:    add 25, 25, 11
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 16(23)
+; CHECK-NEXT:    lfd 1, -16(23)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 24(23)
-; CHECK-NEXT:    mr 23, 3
+; CHECK-NEXT:    lfd 1, -8(23)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfdux 1, 23, 24
+; CHECK-NEXT:    lfd 1, 0(23)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
 ; CHECK-NEXT:    lfd 1, 8(23)
+; CHECK-NEXT:    add 23, 23, 11
+; CHECK-NEXT:    xsadddp 0, 0, 1
+; CHECK-NEXT:    lfd 1, -16(24)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 16(23)
+; CHECK-NEXT:    lfd 1, -8(24)
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    lfd 1, 24(23)
+; CHECK-NEXT:    lfd 1, 0(24)
+; CHECK-NEXT:    xsadddp 0, 0, 1
+; CHECK-NEXT:    lfd 1, 8(24)
+; CHECK-NEXT:    add 24, 24, 11
 ; CHECK-NEXT:    xsadddp 0, 0, 1
-; CHECK-NEXT:    stfdx 0, 4, 25
-; CHECK-NEXT:    add 25, 25, 0
+; CHECK-NEXT:    stfd 0, 0(27)
+; CHECK-NEXT:    add 27, 27, 11
 ; CHECK-NEXT:    blt 0, .LBB0_5
 ; CHECK-NEXT:    b .LBB0_2
 ; CHECK-NEXT:  .LBB0_6: