diff --git a/openmp/CMakeLists.txt b/openmp/CMakeLists.txt
--- a/openmp/CMakeLists.txt
+++ b/openmp/CMakeLists.txt
@@ -66,6 +66,11 @@
   set(ENABLE_LIBOMPTARGET OFF)
 endif()
 
+if (NOT LLVM_MAIN_INCLUDE_DIR)
+  message(STATUS "Missing definition for LLVM_MAIN_INCLUDE_DIR, disabling libomptarget")
+  set(ENABLE_LIBOMPTARGET OFF)
+endif()
+
 option(OPENMP_ENABLE_LIBOMPTARGET "Enable building libomptarget for offloading."
        ${ENABLE_LIBOMPTARGET})
 if (OPENMP_ENABLE_LIBOMPTARGET)
diff --git a/openmp/libomptarget/CMakeLists.txt b/openmp/libomptarget/CMakeLists.txt
--- a/openmp/libomptarget/CMakeLists.txt
+++ b/openmp/libomptarget/CMakeLists.txt
@@ -29,6 +29,11 @@
 # Get dependencies for the different components of the project.
 include(LibomptargetGetDependencies)
 
+# LLVM source tree is required at build time for libomptarget
+if (NOT LLVM_MAIN_INCLUDE_DIR)
+  message(FATAL_ERROR "Missing definition for LLVM_MAIN_INCLUDE_DIR")
+endif()
+
 # This is a list of all the targets that are supported/tested right now.
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} aarch64-unknown-linux-gnu")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} powerpc64le-ibm-linux-gnu")