diff --git a/compiler-rt/include/sanitizer/asan_interface.h b/compiler-rt/include/sanitizer/asan_interface.h
--- a/compiler-rt/include/sanitizer/asan_interface.h
+++ b/compiler-rt/include/sanitizer/asan_interface.h
@@ -323,4 +323,38 @@
 }  // extern "C"
 #endif
 
+// Macro for declaring pointer types that should not be instrumented
+// by ASan. Loads and stores on pointers of this type will not be
+// instrumented.
+//
+// \note Macro is a no-op when ASan is disabled.
+// \note This macro is only supported by Clang.
+//
+// \param TYPE A pointer type.
+//
+// Example:
+//   ASAN_NO_INSTR_PTR(int*) a = 0;
+//   int b = a[0]; // Not instrumented
+//   a[0] = 5; // Not instrumented
+//
+#ifdef __clang__
+#  if defined(__has_feature)
+#    if __has_feature(address_sanitizer)
+#      define ASAN_NO_INSTR_PTR(TYPE) __attribute__((address_space(1))) TYPE
+#    else
+#      define ASAN_NO_INSTR_PTR(TYPE) TYPE
+#    endif
+#  else
+#    error Unreachable
+#  endif
+#else
+   // Using macro on unsupported compilers should be an error
+#  ifdef __GNUC__
+#    define ASAN_NO_INSTR_PTR(TYPE) _Pragma ("GCC error \"ASAN_NO_INSTR_PTR is only supported by Clang\"")
+#  else
+     // TODO(dliew): Support other compilers. For now avoid breaking compilation.
+#    define ASAN_NO_INSTR_PTR(TYPE) TYPE
+#  endif
+#endif
+
 #endif  // SANITIZER_ASAN_INTERFACE_H
diff --git a/compiler-rt/test/asan/TestCases/no_instrument_pointer.cpp b/compiler-rt/test/asan/TestCases/no_instrument_pointer.cpp
new file mode 100644
--- /dev/null
+++ b/compiler-rt/test/asan/TestCases/no_instrument_pointer.cpp
@@ -0,0 +1,46 @@
+// REQUIRES: Clang
+// Check non-instrumented binary using ASAN_NO_INSTR_PTR compiles and runs.
+// RUN: %clangxx -O0 %s -DUSE_ASAN_MACRO -o %t.no_asan
+// RUN: %run %t.no_asan
+
+// Check instrumented binary without ASAN_NO_INSTR_PTR detects the access to poisoned memory.
+// RUN: %clangxx_asan -O0 %s -o %t.asan_find_poison
+// RUN: not %run %t.asan_find_poison 2>&1 | FileCheck -check-prefix=CHECK-POISON %s
+
+// Check instrumented binary with ASAN_NO_INSTR_PTR does not detect access to poisoned memory.
+// RUN: %clangxx_asan -O0 -DUSE_ASAN_MACRO %s -o %t.asan_no_find_poison
+// RUN: %run %t.asan_no_find_poison
+#include "sanitizer/asan_interface.h"
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+
+
+#ifndef ASAN_NO_INSTR_PTR
+#error ASAN_NO_INSTR_PTR macro is missing
+#endif
+
+int *source() {
+  unsigned size = sizeof(int) * 32;
+  int *a = (int *)malloc(size);
+  memset(a, 0, size);
+#if __has_feature(address_sanitizer)
+  __asan_poison_memory_region(a, size);
+#endif
+  return a;
+}
+
+int main() {
+#ifdef USE_ASAN_MACRO
+  ASAN_NO_INSTR_PTR(int *)
+  ptr = (ASAN_NO_INSTR_PTR(int *))source();
+#else
+  int *ptr = source();
+#endif
+
+  // CHECK-POISON: AddressSanitizer: use-after-poison
+  printf("READ: %d\n", ptr[0]); // Read
+  ptr[0] = 5;                   // Write
+  free((int *)ptr);
+  return 0;
+}
diff --git a/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp b/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp
--- a/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp
+++ b/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp
@@ -1364,6 +1364,8 @@
   // Do not instrument acesses from different address spaces; we cannot deal
   // with them.
   Type *PtrTy = cast<PointerType>(Ptr->getType()->getScalarType());
+  // If this condition is ever changed the `ASAN_NO_INSTR_PTR` macro
+  // in `compiler-rt/include/sanitizer/asan_interface.h` must be updated.
   if (PtrTy->getPointerAddressSpace() != 0)
     return true;