diff --git a/llvm/lib/Transforms/IPO/OpenMPOpt.cpp b/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
--- a/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
+++ b/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
@@ -1480,6 +1480,9 @@
     auto &SetterRFI = OMPInfoCache.RFIs[OMPInfoCache.ICVs[ICV].Setter];
     Function *CalledFunction = CB->getCalledFunction();
 
+    // Indirect call, assume ICV changes.
+    if (CalledFunction == nullptr)
+      return nullptr;
     if (CalledFunction == GetterRFI.Declaration)
       return None;
     if (CalledFunction == SetterRFI.Declaration) {