diff --git a/compiler-rt/lib/tsan/rtl/tsan_platform.h b/compiler-rt/lib/tsan/rtl/tsan_platform.h
--- a/compiler-rt/lib/tsan/rtl/tsan_platform.h
+++ b/compiler-rt/lib/tsan/rtl/tsan_platform.h
@@ -26,6 +26,18 @@
 #if !SANITIZER_GO
 
 #if defined(__x86_64__)
+#define HAS_48_BIT_ADDRESS_SPACE 1
+#elif SANITIZER_IOSSIM // arm64 iOS simulators (order of #if matters)
+#define HAS_48_BIT_ADDRESS_SPACE 1
+#elif SANITIZER_IOS // arm64 iOS devices (order of #if matters)
+#define HAS_48_BIT_ADDRESS_SPACE 0
+#elif SANITIZER_MAC // arm64 macOS (order of #if matters)
+#define HAS_48_BIT_ADDRESS_SPACE 1
+#else
+#define HAS_48_BIT_ADDRESS_SPACE 0
+#endif
+
+#if HAS_48_BIT_ADDRESS_SPACE
 /*
 C/C++ on linux/x86_64 and freebsd/x86_64
 0000 0000 1000 - 0080 0000 0000: main binary and/or MAP_32BIT mappings (512GB)
@@ -146,7 +158,7 @@
   static const uptr kVdsoBeg       = 0x7000000000000000ull;
 };
 
-#elif defined(__aarch64__)
+#elif defined(__aarch64__) && !defined(__APPLE__)
 // AArch64 supports multiple VMA which leads to multiple address transformation
 // functions.  To support these multiple VMAS transformations and mappings TSAN
 // runtime for AArch64 uses an external memory read (vmaSize) to select which
@@ -354,7 +366,7 @@
 #define TSAN_RUNTIME_VMA 1
 #endif
 
-#elif SANITIZER_GO && !SANITIZER_WINDOWS && defined(__x86_64__)
+#elif SANITIZER_GO && !SANITIZER_WINDOWS && HAS_48_BIT_ADDRESS_SPACE
 
 /* Go on linux, darwin and freebsd on x86_64
 0000 0000 1000 - 0000 1000 0000: executable
diff --git a/compiler-rt/lib/tsan/rtl/tsan_platform_mac.cpp b/compiler-rt/lib/tsan/rtl/tsan_platform_mac.cpp
--- a/compiler-rt/lib/tsan/rtl/tsan_platform_mac.cpp
+++ b/compiler-rt/lib/tsan/rtl/tsan_platform_mac.cpp
@@ -234,7 +234,7 @@
 #endif
 
 void InitializePlatformEarly() {
-#if !SANITIZER_GO && defined(__aarch64__)
+#if !SANITIZER_GO && !HAS_48_BIT_ADDRESS_SPACE
   uptr max_vm = GetMaxUserVirtualAddress() + 1;
   if (max_vm != Mapping::kHiAppMemEnd) {
     Printf("ThreadSanitizer: unsupported vm address limit %p, expected %p.\n",
diff --git a/compiler-rt/lib/tsan/rtl/tsan_platform_posix.cpp b/compiler-rt/lib/tsan/rtl/tsan_platform_posix.cpp
--- a/compiler-rt/lib/tsan/rtl/tsan_platform_posix.cpp
+++ b/compiler-rt/lib/tsan/rtl/tsan_platform_posix.cpp
@@ -99,7 +99,7 @@
     Die();
   }
 
-#if defined(__aarch64__) && defined(__APPLE__)
+#if defined(__aarch64__) && !HAS_48_BIT_ADDRESS_SPACE
   ProtectRange(HeapMemEnd(), ShadowBeg());
   ProtectRange(ShadowEnd(), MetaShadowBeg());
   ProtectRange(MetaShadowEnd(), TraceMemBeg());