diff --git a/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp b/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp
--- a/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp
+++ b/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp
@@ -158,6 +158,10 @@
     return;
   }
 
+  // Mark spill register as used so we will not choose it as `OffsetReg`,
+  // Otherwise, spill register may possibly get killed even before spill
+  LiveRegs.addReg(SpillReg);
+
   MCPhysReg OffsetReg = findScratchNonCalleeSaveRegister(
     MF->getRegInfo(), LiveRegs, AMDGPU::VGPR_32RegClass);