diff --git a/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp b/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp
--- a/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp
+++ b/llvm/lib/Target/AMDGPU/SIFrameLowering.cpp
@@ -158,6 +158,10 @@
     return;
   }
 
+  // Mark spill register as used so we will not choose it as `OffsetReg`,
+  // Otherwise, spill register may possibly get killed even before spill
+  LiveRegs.addReg(SpillReg);
+
   MCPhysReg OffsetReg = findScratchNonCalleeSaveRegister(
     MF->getRegInfo(), LiveRegs, AMDGPU::VGPR_32RegClass);
 
diff --git a/llvm/test/CodeGen/AMDGPU/frame-pointer-spill.mir b/llvm/test/CodeGen/AMDGPU/frame-pointer-spill.mir
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/AMDGPU/frame-pointer-spill.mir
@@ -0,0 +1,164 @@
+# RUN: llc -mtriple=amdgcn-amd-amdhsa -mcpu=gfx900 -run-pass=prologepilog -verify-machineinstrs %s -o - | FileCheck -check-prefixes=CHECK,GFX9 %s
+
+# copying of frame pointer followed by copying of stack offset should happen to two different registers (say, $vgpr4 and $vgpr5)
+
+---
+name:            frame_pointer_register_different_from_offset_register
+tracksRegLiveness: true
+frameInfo:
+  hasCalls:        true
+machineFunctionInfo:
+  scratchRSrcReg:  '$sgpr0_sgpr1_sgpr2_sgpr3'
+  frameOffsetReg:  '$sgpr33'
+  stackPtrOffsetReg: '$sgpr32'
+stack:
+  - { id: 0, name: '', type: default, offset: 0, size: 30000,
+      alignment: 16, stack-id: default, callee-saved-register: '', callee-saved-restored: true,
+      local-offset: 0, debug-info-variable: '', debug-info-expression: '',
+      debug-info-location: '' }
+body:             |
+  bb.0:
+    liveins: $vgpr0, $vgpr1, $vgpr2, $vgpr3, $vgpr63, $sgpr30_sgpr31
+
+    ; CHECK-LABEL: name: frame_pointer_register_different_from_offset_register
+    ; CHECK: liveins: $vgpr0, $vgpr1, $vgpr2, $vgpr3
+
+    ; GFX9: $vgpr4 = V_MOV_B32_e32 $sgpr33, implicit $exec
+    ; GFX9: $vgpr5 = V_MOV_B32_e32 30452, implicit $exec
+    ; GFX9: BUFFER_STORE_DWORD_OFFEN killed $vgpr4, killed $vgpr5, $sgpr0_sgpr1_sgpr2_sgpr3, $sgpr32
+
+    $sgpr0 = S_GETREG_B32 30735, implicit-def $vgpr0_vgpr1, implicit-def $vcc
+    $sgpr1 = S_GETREG_B32 30735, implicit-def $vgpr2_vgpr3
+    $sgpr2 = S_GETREG_B32 30735, implicit-def $vgpr4_vgpr5
+    $sgpr3 = S_GETREG_B32 30735, implicit-def $vgpr6_vgpr7
+    $sgpr4 = S_GETREG_B32 30735, implicit-def $vgpr8_vgpr9
+    $sgpr5 = S_GETREG_B32 30735, implicit-def $vgpr10_vgpr11
+    $sgpr6 = S_GETREG_B32 30735, implicit-def $vgpr12_vgpr13
+    $sgpr7 = S_GETREG_B32 30735, implicit-def $vgpr14_vgpr15
+    $sgpr8 = S_GETREG_B32 30735, implicit-def $vgpr16_vgpr17
+    $sgpr9 = S_GETREG_B32 30735, implicit-def $vgpr18_vgpr19
+    $sgpr10 = S_GETREG_B32 30735, implicit-def $vgpr20_vgpr21
+    $sgpr11 = S_GETREG_B32 30735, implicit-def $vgpr22_vgpr23
+    $sgpr12 = S_GETREG_B32 30735, implicit-def $vgpr24_vgpr25
+    $sgpr13 = S_GETREG_B32 30735, implicit-def $vgpr26_vgpr27
+    $sgpr14 = S_GETREG_B32 30735, implicit-def $vgpr28_vgpr29
+    $sgpr15 = S_GETREG_B32 30735, implicit-def $vgpr30_vgpr31
+    $sgpr16 = S_GETREG_B32 30735, implicit-def $vgpr32_vgpr33
+    $sgpr17 = S_GETREG_B32 30735, implicit-def $vgpr34_vgpr35
+    $sgpr18 = S_GETREG_B32 30735, implicit-def $vgpr36_vgpr37
+    $sgpr19 = S_GETREG_B32 30735, implicit-def $vgpr38_vgpr39
+    $sgpr20 = S_GETREG_B32 30735, implicit-def $vgpr40_vgpr41
+    $sgpr21 = S_GETREG_B32 30735, implicit-def $vgpr42_vgpr43
+    $sgpr22 = S_GETREG_B32 30735, implicit-def $vgpr44_vgpr45
+    $sgpr23 = S_GETREG_B32 30735, implicit-def $vgpr46_vgpr47
+    $sgpr24 = S_GETREG_B32 30735, implicit-def $vgpr48_vgpr49
+    $sgpr25 = S_GETREG_B32 30735, implicit-def $vgpr50_vgpr51
+    $sgpr26 = S_GETREG_B32 30735, implicit-def $vgpr52_vgpr53
+    $sgpr27 = S_GETREG_B32 30735, implicit-def $vgpr54_vgpr55
+    $sgpr28 = S_GETREG_B32 30735, implicit-def $vgpr56_vgpr57
+    $sgpr29 = S_GETREG_B32 30735, implicit-def $vgpr58_vgpr59
+    $sgpr30 = S_GETREG_B32 30735, implicit-def $vgpr60_vgpr61
+    $sgpr31 = S_GETREG_B32 30735, implicit-def $vgpr62_vgpr63
+    $sgpr32 = S_GETREG_B32 30735, implicit-def $vgpr64_vgpr65
+    $sgpr33 = S_GETREG_B32 30735, implicit-def $vgpr66_vgpr67
+    $sgpr34 = S_GETREG_B32 30735, implicit-def $vgpr68_vgpr69
+    $sgpr35 = S_GETREG_B32 30735, implicit-def $vgpr70_vgpr71
+    $sgpr36 = S_GETREG_B32 30735, implicit-def $vgpr72_vgpr73
+    $sgpr37 = S_GETREG_B32 30735, implicit-def $vgpr74_vgpr75
+    $sgpr38 = S_GETREG_B32 30735, implicit-def $vgpr76_vgpr77
+    $sgpr39 = S_GETREG_B32 30735, implicit-def $vgpr78_vgpr79
+    $sgpr40 = S_GETREG_B32 30735, implicit-def $vgpr80_vgpr81
+    $sgpr41 = S_GETREG_B32 30735, implicit-def $vgpr82_vgpr83
+    $sgpr42 = S_GETREG_B32 30735, implicit-def $vgpr84_vgpr85
+    $sgpr43 = S_GETREG_B32 30735, implicit-def $vgpr86_vgpr87
+    $sgpr44 = S_GETREG_B32 30735, implicit-def $vgpr88_vgpr89
+    $sgpr45 = S_GETREG_B32 30735, implicit-def $vgpr90_vgpr91
+    $sgpr46 = S_GETREG_B32 30735, implicit-def $vgpr92_vgpr93
+    $sgpr47 = S_GETREG_B32 30735, implicit-def $vgpr94_vgpr95
+    $sgpr48 = S_GETREG_B32 30735, implicit-def $vgpr96_vgpr97
+    $sgpr49 = S_GETREG_B32 30735, implicit-def $vgpr98_vgpr99
+    $sgpr50 = S_GETREG_B32 30735, implicit-def $vgpr100_vgpr101
+    $sgpr51 = S_GETREG_B32 30735, implicit-def $vgpr102_vgpr103
+    $sgpr52 = S_GETREG_B32 30735, implicit-def $vgpr104_vgpr105
+    $sgpr53 = S_GETREG_B32 30735, implicit-def $vgpr106_vgpr107
+    $sgpr54 = S_GETREG_B32 30735, implicit-def $vgpr108_vgpr109
+    $sgpr55 = S_GETREG_B32 30735, implicit-def $vgpr110_vgpr111
+    $sgpr56 = S_GETREG_B32 30735, implicit-def $vgpr112_vgpr113
+    $sgpr57 = S_GETREG_B32 30735, implicit-def $vgpr114_vgpr115
+    $sgpr58 = S_GETREG_B32 30735, implicit-def $vgpr116_vgpr117
+    $sgpr59 = S_GETREG_B32 30735, implicit-def $vgpr118_vgpr119
+    $sgpr60 = S_GETREG_B32 30735, implicit-def $vgpr120_vgpr121
+    $sgpr61 = S_GETREG_B32 30735, implicit-def $vgpr122_vgpr123
+    $sgpr62 = S_GETREG_B32 30735, implicit-def $vgpr124_vgpr125
+    $sgpr63 = S_GETREG_B32 30735, implicit-def $vgpr126_vgpr127
+    $sgpr64 = S_GETREG_B32 30735, implicit-def $vgpr128_vgpr129
+    $sgpr65 = S_GETREG_B32 30735, implicit-def $vgpr130_vgpr131
+    $sgpr66 = S_GETREG_B32 30735, implicit-def $vgpr132_vgpr133
+    $sgpr67 = S_GETREG_B32 30735, implicit-def $vgpr134_vgpr135
+    $sgpr68 = S_GETREG_B32 30735, implicit-def $vgpr136_vgpr137
+    $sgpr69 = S_GETREG_B32 30735, implicit-def $vgpr138_vgpr139
+    $sgpr70 = S_GETREG_B32 30735, implicit-def $vgpr140_vgpr141
+    $sgpr71 = S_GETREG_B32 30735, implicit-def $vgpr142_vgpr143
+    $sgpr72 = S_GETREG_B32 30735, implicit-def $vgpr144_vgpr145
+    $sgpr73 = S_GETREG_B32 30735, implicit-def $vgpr146_vgpr147
+    $sgpr74 = S_GETREG_B32 30735, implicit-def $vgpr148_vgpr149
+    $sgpr75 = S_GETREG_B32 30735, implicit-def $vgpr150_vgpr151
+    $sgpr76 = S_GETREG_B32 30735, implicit-def $vgpr152_vgpr153
+    $sgpr77 = S_GETREG_B32 30735, implicit-def $vgpr154_vgpr155
+    $sgpr78 = S_GETREG_B32 30735, implicit-def $vgpr156_vgpr157
+    $sgpr79 = S_GETREG_B32 30735, implicit-def $vgpr158_vgpr159
+    $sgpr80 = S_GETREG_B32 30735, implicit-def $vgpr160_vgpr161
+    $sgpr81 = S_GETREG_B32 30735, implicit-def $vgpr162_vgpr163
+    $sgpr82 = S_GETREG_B32 30735, implicit-def $vgpr164_vgpr165
+    $sgpr83 = S_GETREG_B32 30735, implicit-def $vgpr166_vgpr167
+    $sgpr84 = S_GETREG_B32 30735, implicit-def $vgpr168_vgpr169
+    $sgpr85 = S_GETREG_B32 30735, implicit-def $vgpr170_vgpr171
+    $sgpr86 = S_GETREG_B32 30735, implicit-def $vgpr172_vgpr173
+    $sgpr87 = S_GETREG_B32 30735, implicit-def $vgpr174_vgpr175
+    $sgpr88 = S_GETREG_B32 30735, implicit-def $vgpr176_vgpr177
+    $sgpr89 = S_GETREG_B32 30735, implicit-def $vgpr178_vgpr179
+    $sgpr90 = S_GETREG_B32 30735, implicit-def $vgpr180_vgpr181
+    $sgpr91 = S_GETREG_B32 30735, implicit-def $vgpr182_vgpr183
+    $sgpr92 = S_GETREG_B32 30735, implicit-def $vgpr184_vgpr185
+    $sgpr93 = S_GETREG_B32 30735, implicit-def $vgpr186_vgpr187
+    $sgpr94 = S_GETREG_B32 30735, implicit-def $vgpr188_vgpr189
+    $sgpr95 = S_GETREG_B32 30735, implicit-def $vgpr190_vgpr191
+    $sgpr96 = S_GETREG_B32 30735, implicit-def $vgpr192_vgpr193
+    $sgpr97 = S_GETREG_B32 30735, implicit-def $vgpr194_vgpr195
+    $sgpr98 = S_GETREG_B32 30735, implicit-def $vgpr196_vgpr197
+    $sgpr99 = S_GETREG_B32 30735, implicit-def $vgpr198_vgpr199
+    $sgpr100 = S_GETREG_B32 30735, implicit-def $vgpr200_vgpr201
+    $sgpr101 = S_GETREG_B32 30735, implicit-def $vgpr202_vgpr203
+    $sgpr102 = S_GETREG_B32 30735, implicit-def $vgpr204_vgpr205
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr206_vgpr207
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr208_vgpr209
+
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr210_vgpr211
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr212_vgpr213
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr214_vgpr215
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr216_vgpr217
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr218_vgpr219
+
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr220_vgpr221
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr222_vgpr223
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr224_vgpr225
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr226_vgpr227
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr228_vgpr229
+
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr230_vgpr231
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr232_vgpr233
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr234_vgpr235
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr236_vgpr237
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr238_vgpr239
+
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr240_vgpr241
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr242_vgpr243
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr244_vgpr245
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr246_vgpr247
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr248_vgpr249
+
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr250_vgpr251
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr252_vgpr253
+    $sgpr103 = S_GETREG_B32 30735, implicit-def $vgpr254_vgpr255
+
+...