diff --git a/clang/lib/Basic/Targets/WebAssembly.cpp b/clang/lib/Basic/Targets/WebAssembly.cpp
--- a/clang/lib/Basic/Targets/WebAssembly.cpp
+++ b/clang/lib/Basic/Targets/WebAssembly.cpp
@@ -232,6 +232,7 @@
     }
     if (Feature == "+reference-types") {
       HasReferenceTypes = true;
+      resetDataLayout("e-m:e-p:32:32-i64:64-n32:64-S128-ni:256");
       continue;
     }
     if (Feature == "-reference-types") {