diff --git a/lldb/source/Utility/ArchSpec.cpp b/lldb/source/Utility/ArchSpec.cpp
--- a/lldb/source/Utility/ArchSpec.cpp
+++ b/lldb/source/Utility/ArchSpec.cpp
@@ -987,6 +987,12 @@
   if (lhs == rhs)
     return true;
 
+  // Apple simulators are a different platform than what they simulate.
+  // As the environments are different at this point, if one of them is a
+  // simulator, then they are different.
+  if (lhs == llvm::Triple::Simulator || rhs == llvm::Triple::Simulator)
+    return false;
+
   // If any of the environment is unknown then they are compatible
   if (lhs == llvm::Triple::UnknownEnvironment ||
       rhs == llvm::Triple::UnknownEnvironment)
diff --git a/lldb/unittests/Utility/ArchSpecTest.cpp b/lldb/unittests/Utility/ArchSpecTest.cpp
--- a/lldb/unittests/Utility/ArchSpecTest.cpp
+++ b/lldb/unittests/Utility/ArchSpecTest.cpp
@@ -306,6 +306,14 @@
     ASSERT_FALSE(A.IsExactMatch(B));
     ASSERT_FALSE(A.IsCompatibleMatch(B));
   }
+  {
+    ArchSpec A("arm64-apple-ios");
+    ArchSpec B("arm64-apple-ios-simulator");
+    ASSERT_FALSE(A.IsExactMatch(B));
+    ASSERT_FALSE(A.IsCompatibleMatch(B));
+    ASSERT_FALSE(B.IsCompatibleMatch(A));
+    ASSERT_FALSE(B.IsCompatibleMatch(A));
+  }
   {
     ArchSpec A("arm64-*-*");
     ArchSpec B("arm64-apple-ios");