diff --git a/llvm/include/llvm/Transforms/IPO/OpenMPOpt.h b/llvm/include/llvm/Transforms/IPO/OpenMPOpt.h
--- a/llvm/include/llvm/Transforms/IPO/OpenMPOpt.h
+++ b/llvm/include/llvm/Transforms/IPO/OpenMPOpt.h
@@ -33,6 +33,11 @@
   bool isKnown() { return Value != OpenMP::UNKNOWN; }
   operator bool() { return Value != OpenMP::NOT_FOUND; }
 
+  /// Does this function \p F contain any OpenMP runtime calls?
+  bool containsOMPRuntimeCalls(Function *F) const {
+    return FuncsWithOMPRuntimeCalls.contains(F);
+  }
+
   /// Return the known kernels (=GPU entry points) in the module.
   SmallPtrSetImpl<Kernel> &getKernels() { return Kernels; }
 
@@ -42,6 +47,11 @@
 private:
   enum class OpenMP { FOUND, NOT_FOUND, UNKNOWN } Value = OpenMP::UNKNOWN;
 
+  friend bool containsOpenMP(Module &M, OpenMPInModule &OMPInModule);
+
+  /// In which functions are OpenMP runtime calls present?
+  SmallPtrSet<Function *, 32> FuncsWithOMPRuntimeCalls;
+
   /// Collection of known kernels (=GPU entry points) in the module.
   SmallPtrSet<Kernel, 8> Kernels;
 };
diff --git a/llvm/lib/Transforms/IPO/OpenMPOpt.cpp b/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
--- a/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
+++ b/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
@@ -1339,10 +1339,21 @@
     return PreservedAnalyses::all();
 
   SmallVector<Function *, 16> SCC;
-  for (LazyCallGraph::Node &N : C)
-    SCC.push_back(&N.getFunction());
+  // If there are kernels in the module, we have to run on all SCC's.
+  bool SCCIsInteresting = !OMPInModule.getKernels().empty();
+  for (LazyCallGraph::Node &N : C) {
+    Function *Fn = &N.getFunction();
+    SCC.push_back(Fn);
+
+    // Do we already know that the SCC contains kernels,
+    // or that OpenMP functions are called from this SCC?
+    if (SCCIsInteresting)
+      continue;
+    // If not, let's check that.
+    SCCIsInteresting |= OMPInModule.containsOMPRuntimeCalls(Fn);
+  }
 
-  if (SCC.empty())
+  if (!SCCIsInteresting || SCC.empty())
     return PreservedAnalyses::all();
 
   FunctionAnalysisManager &FAM =
@@ -1401,12 +1412,23 @@
       return false;
 
     SmallVector<Function *, 16> SCC;
-    for (CallGraphNode *CGN : CGSCC)
-      if (Function *Fn = CGN->getFunction())
-        if (!Fn->isDeclaration())
-          SCC.push_back(Fn);
+    // If there are kernels in the module, we have to run on all SCC's.
+    bool SCCIsInteresting = !OMPInModule.getKernels().empty();
+    for (CallGraphNode *CGN : CGSCC) {
+      Function *Fn = CGN->getFunction();
+      if (!Fn || Fn->isDeclaration())
+        continue;
+      SCC.push_back(Fn);
 
-    if (SCC.empty())
+      // Do we already know that the SCC contains kernels,
+      // or that OpenMP functions are called from this SCC?
+      if (SCCIsInteresting)
+        continue;
+      // If not, let's check that.
+      SCCIsInteresting |= OMPInModule.containsOMPRuntimeCalls(Fn);
+    }
+
+    if (!SCCIsInteresting || SCC.empty())
       return false;
 
     CallGraph &CG = getAnalysis<CallGraphWrapperPass>().getCallGraph();
@@ -1468,13 +1490,19 @@
   if (OMPInModule.isKnown())
     return OMPInModule;
 
+  auto RecordFunctionsContainingUsesOf = [&](Function *F) {
+    for (User *U : F->users())
+      if (auto *I = dyn_cast<Instruction>(U))
+        OMPInModule.FuncsWithOMPRuntimeCalls.insert(I->getFunction());
+  };
+
   // MSVC doesn't like long if-else chains for some reason and instead just
   // issues an error. Work around it..
   do {
 #define OMP_RTL(_Enum, _Name, ...)                                             \
-  if (M.getFunction(_Name)) {                                                  \
+  if (Function *F = M.getFunction(_Name)) {                                    \
+    RecordFunctionsContainingUsesOf(F);                                        \
     OMPInModule = true;                                                        \
-    break;                                                                     \
   }
 #include "llvm/Frontend/OpenMP/OMPKinds.def"
   } while (false);