diff --git a/clang-tools-extra/clangd/index/SymbolCollector.cpp b/clang-tools-extra/clangd/index/SymbolCollector.cpp
--- a/clang-tools-extra/clangd/index/SymbolCollector.cpp
+++ b/clang-tools-extra/clangd/index/SymbolCollector.cpp
@@ -373,16 +373,12 @@
                                             index::SymbolRoleSet Roles,
                                             SourceLocation Loc) {
   assert(PP.get());
-
-  const auto &SM = PP->getSourceManager();
-  auto DefLoc = MI->getDefinitionLoc();
-  auto SpellingLoc = SM.getSpellingLoc(Loc);
-  bool IsMainFileSymbol = SM.isInMainFile(SM.getExpansionLoc(DefLoc));
-
   // Builtin macros don't have useful locations and aren't needed in completion.
   if (MI->isBuiltinMacro())
     return true;
 
+  const auto &SM = PP->getSourceManager();
+  auto DefLoc = MI->getDefinitionLoc();
   // Also avoid storing predefined macros like __DBL_MIN__.
   if (SM.isWrittenInBuiltinFile(DefLoc))
     return true;
@@ -391,8 +387,13 @@
   if (!ID)
     return true;
 
+  auto SpellingLoc = SM.getSpellingLoc(Loc);
+  bool IsMainFileOnly =
+      SM.isInMainFile(SM.getExpansionLoc(DefLoc)) &&
+      !isHeaderFile(SM.getFileEntryForID(SM.getMainFileID())->getName(),
+                    ASTCtx->getLangOpts());
   // Do not store references to main-file macros.
-  if ((static_cast<unsigned>(Opts.RefFilter) & Roles) && !IsMainFileSymbol &&
+  if ((static_cast<unsigned>(Opts.RefFilter) & Roles) && !IsMainFileOnly &&
       (Opts.RefsInHeaders || SM.getFileID(SpellingLoc) == SM.getMainFileID()))
     MacroRefs[*ID].push_back({Loc, Roles});
 
@@ -401,7 +402,7 @@
     return true;
 
   // Skip main-file macros if we are not collecting them.
-  if (IsMainFileSymbol && !Opts.CollectMainFileSymbols)
+  if (IsMainFileOnly && !Opts.CollectMainFileSymbols)
     return false;
 
   // Mark the macro as referenced if this is a reference coming from the main
@@ -425,11 +426,12 @@
   Symbol S;
   S.ID = std::move(*ID);
   S.Name = Name->getName();
-  if (!IsMainFileSymbol) {
+  if (!IsMainFileOnly) {
     S.Flags |= Symbol::IndexedForCodeCompletion;
     S.Flags |= Symbol::VisibleOutsideFile;
   }
   S.SymInfo = index::getSymbolInfoForMacro(*MI);
+  S.Origin = Opts.Origin;
   std::string FileURI;
   // FIXME: use the result to filter out symbols.
   shouldIndexFile(SM.getFileID(Loc));
diff --git a/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp b/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp
--- a/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp
+++ b/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp
@@ -1402,6 +1402,9 @@
   runSymbolCollector("class Foo {};", /*Main=*/"");
   EXPECT_THAT(Symbols, UnorderedElementsAre(
                            Field(&Symbol::Origin, SymbolOrigin::Static)));
+  runSymbolCollector("#define FOO", /*Main=*/"");
+  EXPECT_THAT(Symbols, UnorderedElementsAre(
+                           Field(&Symbol::Origin, SymbolOrigin::Static)));
 }
 
 TEST_F(SymbolCollectorTest, CollectMacros) {
@@ -1504,6 +1507,13 @@
   EXPECT_THAT(Refs, Contains(Pair(findSymbol(Symbols, "PUNCT").ID, _)));
 }
 
+TEST_F(SymbolCollectorTest, MacrosInHeaders) {
+  CollectorOpts.CollectMacro = true;
+  TestFileName = testPath("test.h");
+  runSymbolCollector("", "#define X");
+  EXPECT_THAT(Symbols,
+              UnorderedElementsAre(AllOf(QName("X"), ForCodeCompletion(true))));
+}
 } // namespace
 } // namespace clangd
 } // namespace clang