Index: clang-tidy/misc/UniqueptrResetReleaseCheck.cpp
===================================================================
--- clang-tidy/misc/UniqueptrResetReleaseCheck.cpp
+++ clang-tidy/misc/UniqueptrResetReleaseCheck.cpp
@@ -22,17 +22,63 @@
       memberCallExpr(
           on(expr().bind("left")), callee(memberExpr().bind("reset_member")),
           callee(methodDecl(hasName("reset"),
-                            ofClass(hasName("::std::unique_ptr")))),
+                            ofClass(recordDecl(hasName("::std::unique_ptr"),
+                                               decl().bind("left_class"))))),
           has(memberCallExpr(
               on(expr().bind("right")),
               callee(memberExpr().bind("release_member")),
-              callee(methodDecl(hasName("release"),
-                                ofClass(hasName("::std::unique_ptr")))))))
+              callee(methodDecl(
+                  hasName("release"),
+                  ofClass(recordDecl(hasName("::std::unique_ptr"),
+                                     decl().bind("right_class"))))))))
           .bind("reset_call"),
       this);
 }
 
+namespace {
+const CXXRecordDecl *
+getDeleterForUniquePtr(const MatchFinder::MatchResult &Result, StringRef ID) {
+  const auto *Class =
+      Result.Nodes.getNodeAs<ClassTemplateSpecializationDecl>(ID);
+  if (!Class) return nullptr;
+  auto DeleterArgument = Class->getTemplateArgs()[1];
+  if (DeleterArgument.getKind() != TemplateArgument::Type) return nullptr;
+  return DeleterArgument.getAsType()->getAsCXXRecordDecl();
+}
+
+bool areDeletersCompatible(const MatchFinder::MatchResult &Result) {
+  const auto *LeftDeleter = getDeleterForUniquePtr(Result, "left_class");
+  const auto *RightDeleter = getDeleterForUniquePtr(Result, "right_class");
+  if (!LeftDeleter || !RightDeleter)
+    return false;
+
+  if (LeftDeleter->getCanonicalDecl() == RightDeleter->getCanonicalDecl()) {
+    // Same class. We assume they are compatible.
+    return true;
+  }
+
+  const auto *LeftAsTemplate =
+      dyn_cast<ClassTemplateSpecializationDecl>(LeftDeleter);
+  const auto *RightAsTemplate =
+      dyn_cast<ClassTemplateSpecializationDecl>(RightDeleter);
+  if (LeftAsTemplate && RightAsTemplate &&
+      LeftAsTemplate->getSpecializedTemplate() ==
+      RightAsTemplate->getSpecializedTemplate()) {
+    // They are different instantiations of the same template. We assume they
+    // are compatible.
+    // This handles things like std::default_delete<Base> vs.
+    // std::default_delete<Derived>.
+    return true;
+  }
+  return false;
+}
+
+}  // namespace
+
 void UniqueptrResetReleaseCheck::check(const MatchFinder::MatchResult &Result) {
+  if (!areDeletersCompatible(Result))
+    return;
+
   const auto *ResetMember = Result.Nodes.getNodeAs<MemberExpr>("reset_member");
   const auto *ReleaseMember =
       Result.Nodes.getNodeAs<MemberExpr>("release_member");
@@ -41,6 +87,7 @@
   const auto *ResetCall =
       Result.Nodes.getNodeAs<CXXMemberCallExpr>("reset_call");
 
+
   std::string LeftText = clang::Lexer::getSourceText(
       CharSourceRange::getTokenRange(Left->getSourceRange()),
       *Result.SourceManager, Result.Context->getLangOpts());
Index: test/clang-tidy/misc-uniqueptr-reset-release.cpp
===================================================================
--- test/clang-tidy/misc-uniqueptr-reset-release.cpp
+++ test/clang-tidy/misc-uniqueptr-reset-release.cpp
@@ -2,12 +2,16 @@
 // REQUIRES: shell
 
 namespace std {
+
 template <typename T>
+struct default_delete {};
+
+template <typename T, class Deleter = std::default_delete<T>>
 struct unique_ptr {
-  unique_ptr<T>();
-  explicit unique_ptr<T>(T *);
-  template <typename U>
-  unique_ptr<T>(unique_ptr<U> &&);
+  unique_ptr();
+  explicit unique_ptr(T *);
+  template <typename U, typename E>
+  unique_ptr(unique_ptr<U, E> &&);
   void reset(T *);
   T *release();
 };
@@ -46,3 +50,9 @@
   // CHECK-FIXES: *Get() = std::move(*Get());
 }
 
+void negatives() {
+  std::unique_ptr<Foo> src;
+  struct OtherDeleter {};
+  std::unique_ptr<Foo, OtherDeleter> dest;
+  dest.reset(src.release());
+}