diff --git a/compiler-rt/cmake/Modules/CompilerRTDarwinUtils.cmake b/compiler-rt/cmake/Modules/CompilerRTDarwinUtils.cmake
--- a/compiler-rt/cmake/Modules/CompilerRTDarwinUtils.cmake
+++ b/compiler-rt/cmake/Modules/CompilerRTDarwinUtils.cmake
@@ -169,25 +169,46 @@
     CACHE STRING "List of valid architectures for platform ${os}." FORCE)
 endfunction()
 
-# This function checks the host cpusubtype to see if it is post-haswell. Haswell
-# and later machines can run x86_64h binaries. Haswell is cpusubtype 8.
+# This function checks the host cputype/cpusubtype to filter supported
+# architecture for the host OS. This is used to determine which tests are
+# available for the host.
 function(darwin_filter_host_archs input output)
   list_intersect(tmp_var DARWIN_osx_ARCHS ${input})
   execute_process(
-    COMMAND sysctl hw.cpusubtype
-    OUTPUT_VARIABLE SUBTYPE)
-
-  string(REGEX MATCH "hw.cpusubtype: ([0-9]*)"
-         SUBTYPE_MATCHED "${SUBTYPE}")
-  set(HASWELL_SUPPORTED Off)
-  if(SUBTYPE_MATCHED)
-    if(${CMAKE_MATCH_1} GREATER 7)
-      set(HASWELL_SUPPORTED On)
+    COMMAND sysctl hw.cputype
+    OUTPUT_VARIABLE CPUTYPE)
+  string(REGEX MATCH "hw.cputype: ([0-9]*)"
+         CPUTYPE_MATCHED "${CPUTYPE}")
+  set(ARM_HOST Off)
+  if(CPUTYPE_MATCHED)
+    # ARM cputype is (0x01000000 | 12) and X86(_64) is always 7.
+    if(${CMAKE_MATCH_1} GREATER 11)
+      set(ARM_HOST On)
     endif()
   endif()
-  if(NOT HASWELL_SUPPORTED)
-    list(REMOVE_ITEM tmp_var x86_64h)
+
+  if(ARM_HOST)
+    list(REMOVE_ITEM tmp_var i386)
+  else()
+    list(REMOVE_ITEM tmp_var arm64)
+    list(REMOVE_ITEM tmp_var arm64e)
+    execute_process(
+      COMMAND sysctl hw.cpusubtype
+      OUTPUT_VARIABLE SUBTYPE)
+    string(REGEX MATCH "hw.cpusubtype: ([0-9]*)"
+           SUBTYPE_MATCHED "${SUBTYPE}")
+
+    set(HASWELL_SUPPORTED Off)
+    if(SUBTYPE_MATCHED)
+      if(${CMAKE_MATCH_1} GREATER 7)
+        set(HASWELL_SUPPORTED On)
+      endif()
+    endif()
+    if(NOT HASWELL_SUPPORTED)
+      list(REMOVE_ITEM tmp_var x86_64h)
+    endif()
   endif()
+
   set(${output} ${tmp_var} PARENT_SCOPE)
 endfunction()
 
diff --git a/compiler-rt/cmake/builtin-config-ix.cmake b/compiler-rt/cmake/builtin-config-ix.cmake
--- a/compiler-rt/cmake/builtin-config-ix.cmake
+++ b/compiler-rt/cmake/builtin-config-ix.cmake
@@ -64,11 +64,34 @@
   find_darwin_sdk_dir(DARWIN_tvossim_SYSROOT appletvsimulator)
   find_darwin_sdk_dir(DARWIN_tvos_SYSROOT appletvos)
 
+  # Get supported architecture from SDKSettings.
+  function(sdk_has_arch_support sdk_path os arch has_support)
+    execute_process(COMMAND
+        /usr/libexec/PlistBuddy -c "Print :SupportedTargets:${os}:Archs" ${sdk_path}/SDKSettings.plist
+      OUTPUT_VARIABLE SDK_SUPPORTED_ARCHS
+      RESULT_VARIABLE PLIST_ERROR)
+    if (PLIST_ERROR EQUAL 0 AND
+        SDK_SUPPORTED_ARCHS MATCHES " ${arch}\n")
+      message(STATUS "Found ${arch} support in ${sdk_path}/SDKSettings.plist")
+      set("${has_support}" On PARENT_SCOPE)
+    else()
+      message(STATUS "No ${arch} support in ${sdk_path}/SDKSettings.plist")
+      set("${has_support}" Off PARENT_SCOPE)
+    endif()
+  endfunction()
+
   set(DARWIN_EMBEDDED_PLATFORMS)
   set(DARWIN_osx_BUILTIN_MIN_VER 10.5)
   set(DARWIN_osx_BUILTIN_MIN_VER_FLAG
       -mmacosx-version-min=${DARWIN_osx_BUILTIN_MIN_VER})
   set(DARWIN_osx_BUILTIN_ALL_POSSIBLE_ARCHS ${X86} ${X86_64})
+  # Add support for arm64 macOS if available in SDK.
+  foreach(arch ${ARM64})
+    sdk_has_arch_support(${DARWIN_osx_SYSROOT} macosx ${arch} MACOS_ARM_SUPPORT)
+    if (MACOS_ARM_SUPPORT)
+     list(APPEND DARWIN_osx_BUILTIN_ALL_POSSIBLE_ARCHS ${arch})
+    endif()
+  endforeach(arch)
 
   if(COMPILER_RT_ENABLE_IOS)
     list(APPEND DARWIN_EMBEDDED_PLATFORMS ios)
diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h b/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h
--- a/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h
@@ -341,7 +341,7 @@
 #define SANITIZER_INTERCEPT_STATFS \
   (SI_FREEBSD || SI_MAC || SI_LINUX_NOT_ANDROID || SI_SOLARIS)
 #define SANITIZER_INTERCEPT_STATFS64 \
-  ((SI_MAC && !SI_IOS) || SI_LINUX_NOT_ANDROID)
+  (((SI_MAC && !TARGET_CPU_ARM64) && !SI_IOS) || SI_LINUX_NOT_ANDROID)
 #define SANITIZER_INTERCEPT_STATVFS \
   (SI_FREEBSD || SI_NETBSD || SI_OPENBSD || SI_LINUX_NOT_ANDROID)
 #define SANITIZER_INTERCEPT_STATVFS64 SI_LINUX_NOT_ANDROID
diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp
--- a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp
@@ -170,7 +170,7 @@
 namespace __sanitizer {
   unsigned struct_utsname_sz = sizeof(struct utsname);
   unsigned struct_stat_sz = sizeof(struct stat);
-#if !SANITIZER_IOS
+#if !SANITIZER_IOS && !(SANITIZER_MAC && TARGET_CPU_ARM64)
   unsigned struct_stat64_sz = sizeof(struct stat64);
 #endif // !SANITIZER_IOS
   unsigned struct_rusage_sz = sizeof(struct rusage);
@@ -197,7 +197,7 @@
   unsigned struct_regex_sz = sizeof(regex_t);
   unsigned struct_regmatch_sz = sizeof(regmatch_t);
 
-#if SANITIZER_MAC && !SANITIZER_IOS
+#if (SANITIZER_MAC && !TARGET_CPU_ARM64) && !SANITIZER_IOS
   unsigned struct_statfs64_sz = sizeof(struct statfs64);
 #endif // SANITIZER_MAC && !SANITIZER_IOS