diff --git a/llvm/lib/Target/AMDGPU/GCNDPPCombine.cpp b/llvm/lib/Target/AMDGPU/GCNDPPCombine.cpp
--- a/llvm/lib/Target/AMDGPU/GCNDPPCombine.cpp
+++ b/llvm/lib/Target/AMDGPU/GCNDPPCombine.cpp
@@ -513,15 +513,32 @@
       break;
     }
 
+    auto *Src0 = TII->getNamedOperand(OrigMI, AMDGPU::OpName::src0);
+    auto *Src1 = TII->getNamedOperand(OrigMI, AMDGPU::OpName::src1);
+    if (Use != Src0 && !(Use == Src1 && OrigMI.isCommutable())) { // [1]
+      LLVM_DEBUG(dbgs() << "  failed: no suitable operands\n");
+      break;
+    }
+
+    assert(Src0 && "Src1 without Src0?");
+    if (Src1 && Src1->isIdenticalTo(*Src0)) {
+      assert(Src1->isReg());
+      LLVM_DEBUG(
+          dbgs()
+          << "  " << OrigMI
+          << "  failed: DPP register is used more than once per instruction\n");
+      break;
+    }
+
     LLVM_DEBUG(dbgs() << "  combining: " << OrigMI);
-    if (Use == TII->getNamedOperand(OrigMI, AMDGPU::OpName::src0)) {
+    if (Use == Src0) {
       if (auto *DPPInst = createDPPInst(OrigMI, MovMI, CombOldVGPR,
                                         OldOpndValue, CombBCZ)) {
         DPPMIs.push_back(DPPInst);
         Rollback = false;
       }
-    } else if (OrigMI.isCommutable() &&
-               Use == TII->getNamedOperand(OrigMI, AMDGPU::OpName::src1)) {
+    } else {
+      assert(Use == Src1 && OrigMI.isCommutable()); // by check [1]
       auto *BB = OrigMI.getParent();
       auto *NewMI = BB->getParent()->CloneMachineInstr(&OrigMI);
       BB->insert(OrigMI, NewMI);
@@ -535,8 +552,7 @@
       } else
         LLVM_DEBUG(dbgs() << "  failed: cannot be commuted\n");
       NewMI->eraseFromParent();
-    } else
-      LLVM_DEBUG(dbgs() << "  failed: no suitable operands\n");
+    }
     if (Rollback)
       break;
     OrigMIs.push_back(&OrigMI);
diff --git a/llvm/test/CodeGen/AMDGPU/dpp_combine.mir b/llvm/test/CodeGen/AMDGPU/dpp_combine.mir
--- a/llvm/test/CodeGen/AMDGPU/dpp_combine.mir
+++ b/llvm/test/CodeGen/AMDGPU/dpp_combine.mir
@@ -833,3 +833,33 @@
     S_ENDPGM 0, implicit %4
 
 ...
+
+# GCN-LABEL: name: dont_combine_more_than_one_operand
+# GCN: %3:vgpr_32 = V_MAX_F32_e64 0, %2, 0, %2, 0, 0, implicit $mode, implicit $exec
+name: dont_combine_more_than_one_operand
+tracksRegLiveness: true
+body: |
+  bb.0:
+    liveins: $vgpr0, $vgpr1
+    %0:vgpr_32 = COPY $vgpr0
+    %1:vgpr_32 = COPY $vgpr1
+    %2:vgpr_32 = V_MOV_B32_dpp %0, %1, 1, 15, 15, 1, implicit $exec
+    %3:vgpr_32 = V_MAX_F32_e64 0, %2, 0, %2, 0, 0, implicit $mode, implicit $exec
+...
+
+# GCN-LABEL: name: dont_combine_more_than_one_operand_dpp_reg_sequence
+# GCN: %5:vgpr_32 = V_ADD_I32_e32 %4.sub0, %4.sub0, implicit-def $vcc, implicit $exec
+# GCN: %6:vgpr_32 = V_ADDC_U32_e32 %4.sub1, %4.sub1, implicit-def $vcc, implicit $vcc, implicit $exec
+name: dont_combine_more_than_one_operand_dpp_reg_sequence
+tracksRegLiveness: true
+body: |
+  bb.0:
+    liveins: $vgpr0_vgpr1, $vgpr2_vgpr3
+    %0:vreg_64 = COPY $vgpr0_vgpr1
+    %1:vreg_64 = COPY $vgpr2_vgpr3
+    %2:vgpr_32 = V_MOV_B32_dpp %0.sub0, %1.sub0, 1, 15, 15, 1, implicit $exec
+    %3:vgpr_32 = V_MOV_B32_dpp %0.sub1, %1.sub1, 1, 15, 15, 1, implicit $exec
+    %4:vreg_64 = REG_SEQUENCE %2, %subreg.sub0, %3, %subreg.sub1
+    %5:vgpr_32 = V_ADD_I32_e32 %4.sub0, %4.sub0, implicit-def $vcc, implicit $exec
+    %6:vgpr_32 = V_ADDC_U32_e32 %4.sub1, %4.sub1, implicit-def $vcc, implicit $vcc, implicit $exec
+...