diff --git a/lldb/source/Interpreter/embedded_interpreter.py b/lldb/source/Interpreter/embedded_interpreter.py
--- a/lldb/source/Interpreter/embedded_interpreter.py
+++ b/lldb/source/Interpreter/embedded_interpreter.py
@@ -73,7 +73,12 @@
 def readfunc_stdio(prompt):
     sys.stdout.write(prompt)
     sys.stdout.flush()
-    return sys.stdin.readline().rstrip()
+    line = sys.stdin.readline()
+    # Readline always includes a trailing newline character unless the file
+    # ends with an incomplete line. An empty line indicates EOF.
+    if not line:
+        raise EOFError
+    return line.rstrip()
 
 
 def run_python_interpreter(local_dict):
diff --git a/lldb/test/Shell/ScriptInterpreter/Python/eof.test b/lldb/test/Shell/ScriptInterpreter/Python/eof.test
new file mode 100644
--- /dev/null
+++ b/lldb/test/Shell/ScriptInterpreter/Python/eof.test
@@ -0,0 +1,6 @@
+RUN: echo 'foo' | %lldb -o script | FileCheck %s
+
+# Check that the python interpreter detects the OF and the prompt is printed
+# exactly once.
+CHECK: >>>
+CHECK-NOT: >>>