diff --git a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
--- a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
@@ -2480,6 +2480,7 @@
               return false;
             LLVM_FALLTHROUGH;
           }
+          case Intrinsic::assume:
           case Intrinsic::invariant_start:
           case Intrinsic::invariant_end:
           case Intrinsic::lifetime_start:
diff --git a/llvm/test/Transforms/InstCombine/malloc-free-delete.ll b/llvm/test/Transforms/InstCombine/malloc-free-delete.ll
--- a/llvm/test/Transforms/InstCombine/malloc-free-delete.ll
+++ b/llvm/test/Transforms/InstCombine/malloc-free-delete.ll
@@ -276,6 +276,8 @@
 ; delete[](void*, unsigned long, align_val_t)
 declare void @_ZdaPvmSt11align_val_t(i8*, i64, i64) nobuiltin
 
+declare void @llvm.assume(i1)
+
 define void @test8() {
 ; CHECK-LABEL: @test8(
 ; CHECK-NEXT:    ret void
@@ -317,6 +319,12 @@
   call void @_ZdaPvmSt11align_val_t(i8* %naa2, i64 32, i64 8) builtin
   %naja2 = call i8* @_ZnajSt11align_val_t(i32 32, i32 8) builtin
   call void @_ZdaPvjSt11align_val_t(i8* %naja2, i32 32, i32 8) builtin
+
+  ; Check that the alignment assume does not prevent the removal.
+  %nwa3 = call i8* @_ZnwmSt11align_val_t(i64 32, i64 16) builtin
+  call void @llvm.assume(i1 true) [ "align"(i8* %nwa3, i64 16) ]
+  call void @_ZdlPvmSt11align_val_t(i8* %nwa3, i64 32, i64 16) builtin
+
   ret void
 }
 
@@ -343,7 +351,7 @@
 
 define void @test11() {
 ; CHECK-LABEL: @test11(
-; CHECK-NEXT:    [[CALL:%.*]] = call dereferenceable(8) i8* @_Znwm(i64 8) #6
+; CHECK-NEXT:    [[CALL:%.*]] = call dereferenceable(8) i8* @_Znwm(i64 8) #7
 ; CHECK-NEXT:    call void @_ZdlPv(i8* nonnull [[CALL]])
 ; CHECK-NEXT:    ret void
 ;