diff --git a/libc/CMakeLists.txt b/libc/CMakeLists.txt
--- a/libc/CMakeLists.txt
+++ b/libc/CMakeLists.txt
@@ -68,6 +68,22 @@
 
 add_subdirectory(include)
 add_subdirectory(config)
+
+include("${LIBC_SOURCE_DIR}/config/${LIBC_TARGET_OS}/${LIBC_TARGET_MACHINE}/entrypoints.txt")
+include("${LIBC_SOURCE_DIR}/config/${LIBC_TARGET_OS}/${LIBC_TARGET_MACHINE}/headers.txt")
+
+set(TARGET_ENTRYPOINT_NAME_LIST "")
+foreach(entrypoint IN LISTS TARGET_LIBC_ENTRYPOINTS TARGET_LIBM_ENTRYPOINTS)
+  string(FIND ${entrypoint} "." last_dot_loc REVERSE)
+  if(${last_dot_loc} EQUAL -1)
+    message(FATAL "Invalid entrypoint target name ${entrypoint}; Expected a '.' "
+                  "(dot) in the name.")
+  endif()
+  math(EXPR name_loc "${last_dot_loc} + 1")
+  string(SUBSTRING ${entrypoint} ${name_loc} -1 entrypoint_name)
+  list(APPEND TARGET_ENTRYPOINT_NAME_LIST ${entrypoint_name})
+endforeach()
+
 add_subdirectory(src)
 add_subdirectory(utils)
 
diff --git a/libc/cmake/modules/LLVMLibCObjectRules.cmake b/libc/cmake/modules/LLVMLibCObjectRules.cmake
--- a/libc/cmake/modules/LLVMLibCObjectRules.cmake
+++ b/libc/cmake/modules/LLVMLibCObjectRules.cmake
@@ -86,6 +86,23 @@
     set(entrypoint_name ${ADD_ENTRYPOINT_OBJ_NAME})
   endif()
 
+  list(FIND TARGET_ENTRYPOINT_NAME_LIST ${entrypoint_name} entrypoint_name_index)
+  if(${entrypoint_name_index} EQUAL -1)
+    add_custom_target(${fq_target_name})
+    set_target_properties(
+      ${fq_target_name}
+      PROPERTIES
+        "ENTRYPOINT_NAME" ${entrypoint_name}
+        "TARGET_TYPE" ${ENTRYPOINT_OBJ_TARGET_TYPE}
+        "OBJECT_FILE" ""
+        "OBJECT_FILE_RAW" ""
+        "DEPS" ""
+        "SKIPPED" "YES"
+    )
+    message(STATUS "Skipping libc entrypoint ${fq_target_name}.")
+    return()
+  endif()
+
   if(ADD_ENTRYPOINT_OBJ_ALIAS)
     # Alias targets help one add aliases to other entrypoint object targets.
     # One can use alias targets setup OS/machine independent entrypoint targets.
diff --git a/libc/cmake/modules/LLVMLibCTestRules.cmake b/libc/cmake/modules/LLVMLibCTestRules.cmake
--- a/libc/cmake/modules/LLVMLibCTestRules.cmake
+++ b/libc/cmake/modules/LLVMLibCTestRules.cmake
@@ -3,12 +3,18 @@
 # recursively produced by "add_entrypoint_object" and "add_object_library"
 # targets.
 # Usage:
-#   get_object_files_for_test(<result var> <target0> [<target1> ...])
+#   get_object_files_for_test(<result var>
+#                             <skipped_entrypoints_var>
+#                             <target0> [<target1> ...])
 #
+#   The list of object files is collected in <result_var>.
+#   If skipped entrypoints were found, then <skipped_entrypoints_var> is
+#   set to a true value.
 #   targetN is either an "add_entrypoint_target" target or an
 #   "add_object_library" target.
-function(get_object_files_for_test result)
+function(get_object_files_for_test result skipped_entrypoints_list)
   set(object_files "")
+  set(skipped_list "")
   foreach(dep IN LISTS ARGN)
     get_target_property(dep_type ${dep} "TARGET_TYPE")
     if(NOT dep_type)
@@ -23,6 +29,11 @@
         list(APPEND object_files ${dep_object_files})
       endif()
     elseif(${dep_type} STREQUAL ${ENTRYPOINT_OBJ_TARGET_TYPE})
+      get_target_property(is_skipped ${dep} "SKIPPED")
+      if(is_skipped)
+        list(APPEND skipped_list ${dep})
+        continue()
+      endif()
       get_target_property(object_file_raw ${dep} "OBJECT_FILE_RAW")
       if(object_file_raw)
         list(APPEND object_files ${object_file_raw})
@@ -30,11 +41,17 @@
     endif()
 
     get_target_property(indirect_deps ${dep} "DEPS")
-    get_object_files_for_test(indirect_objfiles ${indirect_deps})
+    get_object_files_for_test(
+        indirect_objfiles indirect_skipped_list ${indirect_deps})
     list(APPEND object_files ${indirect_objfiles})
+    if(indirect_skipped_list)
+      list(APPEND skipped_list ${indirect_skipped_list})
+    endif()
   endforeach(dep)
   list(REMOVE_DUPLICATES object_files)
   set(${result} ${object_files} PARENT_SCOPE)
+  list(REMOVE_DUPLICATES skipped_list)
+  set(${skipped_entrypoints_list} ${skipped_list} PARENT_SCOPE)
 endfunction(get_object_files_for_test)
 
 # Rule to add a libc unittest.
@@ -68,8 +85,43 @@
                         "'add_entrypoint_object' targets.")
   endif()
 
-
   get_fq_target_name(${target_name} fq_target_name)
+  get_fq_deps_list(fq_deps_list ${LIBC_UNITTEST_DEPENDS})
+  get_object_files_for_test(
+      link_object_files skipped_entrypoints_list ${fq_deps_list})
+  if(skipped_entrypoints_list)
+    # If a test is OS/target machine independent, it has to be skipped if the
+    # OS/target machine combination does not provide any dependent entrypoints.
+    # If a test is OS/target machine specific, then such a test will live is a
+    # OS/target machine specific directory and will be skipped at the directory
+    # level if required.
+    #
+    # There can potentially be a setup like this: A unittest is setup for a
+    # OS/target machine independent object library, which in turn depends on a
+    # machine specific object library. Such a test would be testing internals of
+    # the libc and it is assumed that they will be rare in practice. So, they
+    # can be skipped in the corresponding CMake files using platform specific
+    # logic. This pattern is followed in the loader tests for example.
+    #
+    # Another pattern that is present currently is to detect machine
+    # capabilities and add entrypoints and tests accordingly. That approach is
+    # much lower level approach and is independent of the kind of skipping that
+    # is happening here at the entrypoint level.
+
+    set(msg "Skipping unittest ${fq_target_name} as it has missing deps: "
+            "${skipped_entrypoints_list}.")
+    message(STATUS ${msg})
+    add_custom_target(${fq_target_name})
+
+    # A post build custom command is used to avoid running the command always.
+    add_custom_command(
+      TARGET ${fq_target_name}
+      POST_BUILD
+      COMMAND ${CMAKE_COMMAND} -E echo ${msg}
+    )
+    return()
+  endif()
+
   add_executable(
     ${fq_target_name}
     EXCLUDE_FROM_ALL
@@ -90,8 +142,6 @@
     )
   endif()
 
-  get_fq_deps_list(fq_deps_list ${LIBC_UNITTEST_DEPENDS})
-  get_object_files_for_test(link_object_files ${fq_deps_list})
   target_link_libraries(${fq_target_name} PRIVATE ${link_object_files})
 
   set_target_properties(${fq_target_name}
diff --git a/libc/config/linux/x86_64/entrypoints.txt b/libc/config/linux/x86_64/entrypoints.txt
--- a/libc/config/linux/x86_64/entrypoints.txt
+++ b/libc/config/linux/x86_64/entrypoints.txt
@@ -1,4 +1,4 @@
-set(LIBC_ENTRYPOINTS
+set(TARGET_LIBC_ENTRYPOINTS
     # assert.h entrypoints
     libc.src.assert.__assert_fail
 
@@ -43,7 +43,7 @@
     libc.src.unistd.write
 )
 
-set(LIBM_ENTRYPOINTS
+set(TARGET_LIBM_ENTRYPOINTS
     # math.h entrypoints
     libc.src.math.ceil
     libc.src.math.ceilf
diff --git a/libc/config/linux/x86_64/headers.txt b/libc/config/linux/x86_64/headers.txt
--- a/libc/config/linux/x86_64/headers.txt
+++ b/libc/config/linux/x86_64/headers.txt
@@ -1,4 +1,4 @@
-set(PUBLIC_HEADERS
+set(TARGET_PUBLIC_HEADERS
     libc.include.assert_h
     libc.include.errno
     libc.include.math
diff --git a/libc/lib/CMakeLists.txt b/libc/lib/CMakeLists.txt
--- a/libc/lib/CMakeLists.txt
+++ b/libc/lib/CMakeLists.txt
@@ -1,16 +1,13 @@
-include("${LIBC_SOURCE_DIR}/config/${LIBC_TARGET_OS}/${LIBC_TARGET_MACHINE}/entrypoints.txt")
-include("${LIBC_SOURCE_DIR}/config/${LIBC_TARGET_OS}/${LIBC_TARGET_MACHINE}/headers.txt")
-
 add_entrypoint_library(
   llvmlibc
   DEPENDS
-  ${LIBC_ENTRYPOINTS}
+  ${TARGET_LIBC_ENTRYPOINTS}
 )
 
 add_entrypoint_library(
   llvmlibm
   DEPENDS
-  ${LIBM_ENTRYPOINTS}
+  ${TARGET_LIBM_ENTRYPOINTS}
 )
 
 add_redirector_library(
diff --git a/libc/loader/linux/CMakeLists.txt b/libc/loader/linux/CMakeLists.txt
--- a/libc/loader/linux/CMakeLists.txt
+++ b/libc/loader/linux/CMakeLists.txt
@@ -56,6 +56,11 @@
   )
 endfunction()
 
+if(NOT (EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/${LIBC_TARGET_MACHINE}))
+  message(STATUS "Skipping loader for target machine ${LIBC_TARGET_MACHINE}")
+  return()
+endif()
+
 add_subdirectory(${LIBC_TARGET_MACHINE})
 
 add_loader_object(
diff --git a/libc/test/loader/CMakeLists.txt b/libc/test/loader/CMakeLists.txt
--- a/libc/test/loader/CMakeLists.txt
+++ b/libc/test/loader/CMakeLists.txt
@@ -38,7 +38,7 @@
   )
 
   get_fq_deps_list(fq_deps_list ${ADD_LOADER_TEST_DEPENDS})
-  get_object_files_for_test(link_object_files ${fq_deps_list})
+  get_object_files_for_test(link_object_files has_skipped_entrypoint_list ${fq_deps_list})
   target_link_libraries(${fq_target_name} ${link_object_files})
 
   target_link_options(
diff --git a/libc/test/loader/linux/CMakeLists.txt b/libc/test/loader/linux/CMakeLists.txt
--- a/libc/test/loader/linux/CMakeLists.txt
+++ b/libc/test/loader/linux/CMakeLists.txt
@@ -1,3 +1,8 @@
+if(NOT (EXISTS ${LIBC_SOURCE_DIR}/loader/linux/${LIBC_TARGET_MACHINE}))
+  message("Skipping loader tests for target machine ${LIBC_TARGET_MACHINE}.")
+  return()
+endif()
+
 add_loader_test(
   loader_args_test
   SRC
diff --git a/libc/test/src/CMakeLists.txt b/libc/test/src/CMakeLists.txt
--- a/libc/test/src/CMakeLists.txt
+++ b/libc/test/src/CMakeLists.txt
@@ -9,13 +9,10 @@
 add_subdirectory(threads)
 add_subdirectory(unistd)
 
-include("${LIBC_SOURCE_DIR}/config/${LIBC_TARGET_OS}/${LIBC_TARGET_MACHINE}/entrypoints.txt")
-include("${LIBC_SOURCE_DIR}/config/${LIBC_TARGET_OS}/${LIBC_TARGET_MACHINE}/headers.txt")
-
 set(public_test ${CMAKE_CURRENT_BINARY_DIR}/public_integration_test.cpp)
 
 set(entrypoints_name_list "")
-foreach(entry IN LISTS LIBC_ENTRYPOINTS LIBM_ENTRYPOINTS)
+foreach(entry IN LISTS TARGET_LIBC_ENTRYPOINTS TARGET_LIBM_ENTRYPOINTS)
   get_target_property(entry_name ${entry} "ENTRYPOINT_NAME")
   list(APPEND entrypoints_name_list ${entry_name})
 endforeach()