Index: llvm/include/llvm/IR/Module.h
===================================================================
--- llvm/include/llvm/IR/Module.h
+++ llvm/include/llvm/IR/Module.h
@@ -593,6 +593,7 @@
   const_global_iterator global_begin() const { return GlobalList.begin(); }
   global_iterator       global_end  ()       { return GlobalList.end(); }
   const_global_iterator global_end  () const { return GlobalList.end(); }
+  size_t                global_size () const { return GlobalList.size(); }
   bool                  global_empty() const { return GlobalList.empty(); }
 
   iterator_range<global_iterator> globals() {
Index: llvm/lib/Transforms/Instrumentation/DataFlowSanitizer.cpp
===================================================================
--- llvm/lib/Transforms/Instrumentation/DataFlowSanitizer.cpp
+++ llvm/lib/Transforms/Instrumentation/DataFlowSanitizer.cpp
@@ -811,16 +811,25 @@
   if (ABIList.isIn(M, "skip"))
     return false;
 
+  const unsigned InitialGlobalSize = M.global_size();
+  const unsigned InitialModuleSize = M.size();
+
+  bool Changed = false;
+
   if (!GetArgTLSPtr) {
     Type *ArgTLSTy = ArrayType::get(ShadowTy, 64);
     ArgTLS = Mod->getOrInsertGlobal("__dfsan_arg_tls", ArgTLSTy);
-    if (GlobalVariable *G = dyn_cast<GlobalVariable>(ArgTLS))
+    if (GlobalVariable *G = dyn_cast<GlobalVariable>(ArgTLS)) {
+      Changed |= G->getThreadLocalMode() != GlobalVariable::InitialExecTLSModel;
       G->setThreadLocalMode(GlobalVariable::InitialExecTLSModel);
+    }
   }
   if (!GetRetvalTLSPtr) {
     RetvalTLS = Mod->getOrInsertGlobal("__dfsan_retval_tls", ShadowTy);
-    if (GlobalVariable *G = dyn_cast<GlobalVariable>(RetvalTLS))
+    if (GlobalVariable *G = dyn_cast<GlobalVariable>(RetvalTLS)) {
+      Changed |= G->getThreadLocalMode() != GlobalVariable::InitialExecTLSModel;
       G->setThreadLocalMode(GlobalVariable::InitialExecTLSModel);
+    }
   }
 
   ExternalShadowMask =
@@ -1044,7 +1053,8 @@
     }
   }
 
-  return false;
+  return Changed || !FnsToInstrument.empty() ||
+         M.global_size() != InitialGlobalSize || M.size() != InitialModuleSize;
 }
 
 Value *DFSanFunction::getArgTLSPtr() {