diff --git a/buildbot/osuosl/master/config/builders.py b/buildbot/osuosl/master/config/builders.py
--- a/buildbot/osuosl/master/config/builders.py
+++ b/buildbot/osuosl/master/config/builders.py
@@ -1662,6 +1662,54 @@
              }
            ]
 
+# Builders for ML-driven compiler optimizations.
+def _get_ml_compiler_opt_builders():
+    common_extra_args = [
+        "-DCMAKE_BUILD_TYPE=Release",
+        "-DLLVM_CACHE_BUILD=ON",
+        "-DLLVM_ENABLE_ASSERTIONS=ON", ]
+
+    return [
+        # Development mode build bot: tensorflow C APIs are present, and 
+        # we can dynamically load models, and produce training logs.
+        {'name': "ml-opt-dev-x86-64",
+         'mergeRequests': False,
+         'slavenames':["ml-opt-dev-x86-64-b1"],
+         'builddir':"ml-opt-dev-x86-64-b1",
+         'factory': UnifiedTreeBuilder.getCmakeWithNinjaBuildFactory(
+                        clean=True,
+                        depends_on_projects=['llvm'],
+                        extra_configure_args=common_extra_args + [
+                            "-DTENSORFLOW_API_PATH=${TENSORFLOW_API_PATH}"
+                        ])},
+        # Release mode build bot: the model is pre-built and linked in the
+        # compiler. Only the tensorflow pip package is needed, and out of it,
+        # only saved_model_cli (the model compiler) and the thin C++ wrappers
+        # in xla_aot_runtime_src (and include files)
+        {'name': "ml-opt-rel-x86-64",
+         'mergeRequests': False,
+         'slavenames':["ml-opt-rel-x86-64-b1"],
+         'builddir':"ml-opt-rel-x86-64-b1",
+         'factory': UnifiedTreeBuilder.getCmakeWithNinjaBuildFactory(
+                        clean=True,
+                        depends_on_projects=['llvm'],
+                        extra_configure_args=common_extra_args + [
+                            "-DTENSORFLOW_AOT_PATH=${TENSORFLOW_AOT_PATH}"
+                        ])},
+        # Both tensorflow C library, and the pip package, are present.
+        {'name': "ml-opt-devrel-x86-64",
+         'mergeRequests': False,
+         'slavenames':["ml-opt-devrel-x86-64-b1"],
+         'builddir':"ml-opt-devrel-x86-64-b1",
+         'factory': UnifiedTreeBuilder.getCmakeWithNinjaBuildFactory(
+                        clean=True,
+                        depends_on_projects=['llvm'],
+                        extra_configure_args=common_extra_args + [
+                            "-DTENSORFLOW_API_PATH=${TENSORFLOW_API_PATH}",
+                            "-DTENSORFLOW_AOT_PATH=${TENSORFLOW_AOT_PATH}"
+                        ])},
+    ]
+
 def get_builders():
     for b in _get_llvm_builders():
         b['category'] = 'llvm'
@@ -1698,6 +1746,10 @@
     for b in _get_mlir_builders():
         b['category'] = 'mlir'
         yield b
+    
+    for b in _get_ml_compiler_opt_builders():
+        b['category'] = 'ml_opt'
+        yield b
 
     for b in _get_sanitizer_builders():
         b['category'] = 'sanitizer'
diff --git a/buildbot/osuosl/master/config/slaves.py b/buildbot/osuosl/master/config/slaves.py
--- a/buildbot/osuosl/master/config/slaves.py
+++ b/buildbot/osuosl/master/config/slaves.py
@@ -236,4 +236,12 @@
         create_slave("flang-aarch64-ubuntu-build"),
         create_slave("flang-aarch64-ubuntu-clang-build"),
         create_slave("nersc-flang"),
+
+        # ML-Driven Compiler Optimizations build slave (Ubuntu x86_64)
+        create_slave("ml-opt-dev-x86-64-b1",
+                     properties={'jobs': 64}, max_builds=1),
+        create_slave("ml-opt-rel-x86-64-b1",
+                     properties={'jobs': 64}, max_builds=1),
+        create_slave("ml-opt-devrel-x86-64-b1",
+                     properties={'jobs': 64}, max_builds=1),
         ]
diff --git a/buildbot/osuosl/master/config/status.py b/buildbot/osuosl/master/config/status.py
--- a/buildbot/osuosl/master/config/status.py
+++ b/buildbot/osuosl/master/config/status.py
@@ -288,4 +288,13 @@
             mode = "failing",
             builders = ["publish-sphinx-docs"],
             addLogs=False),
+        InformativeMailNotifier(fromaddr="llvm.buildmaster@lab.llvm.org",
+            sendToInterestedUsers=True,
+            extraRecipients=[
+                "mlcompileropt-buildbot@google.com"],
+            subject="ML Compiler Opt Failure: %(builder)s",
+            mode="failing",
+            builders=[
+                "ml-opt-dev-x86-64", "ml-opt-rel-x86-64", "ml-opt-devrel-x86-64"],
+            addLogs=False),
         ]