diff --git a/clang-tools-extra/clang-tidy/cppcoreguidelines/ProTypeVarargCheck.cpp b/clang-tools-extra/clang-tidy/cppcoreguidelines/ProTypeVarargCheck.cpp
--- a/clang-tools-extra/clang-tidy/cppcoreguidelines/ProTypeVarargCheck.cpp
+++ b/clang-tools-extra/clang-tidy/cppcoreguidelines/ProTypeVarargCheck.cpp
@@ -18,11 +18,20 @@
 
 const internal::VariadicDynCastAllOfMatcher<Stmt, VAArgExpr> vAArgExpr;
 
+// FIXME: Add any more builtin variadics that shouldn't trigger this
+static constexpr StringRef AllowedVariadics[] = {
+    "__builtin_constant_p", "__builtin_isinf_sign", "__builtin_assume_aligned",
+    "__builtin_prefetch",   "__builtin_fpclassify",
+};
+
 void ProTypeVarargCheck::registerMatchers(MatchFinder *Finder) {
   Finder->addMatcher(vAArgExpr().bind("va_use"), this);
 
   Finder->addMatcher(
-      callExpr(callee(functionDecl(isVariadic()))).bind("callvararg"), this);
+      callExpr(callee(functionDecl(isVariadic(),
+                                   unless(hasAnyName(AllowedVariadics)))))
+          .bind("callvararg"),
+      this);
 }
 
 static bool hasSingleVariadicArgumentWithValue(const CallExpr *C, uint64_t I) {
diff --git a/clang-tools-extra/test/clang-tidy/checkers/cppcoreguidelines-pro-type-vararg.cpp b/clang-tools-extra/test/clang-tidy/checkers/cppcoreguidelines-pro-type-vararg.cpp
--- a/clang-tools-extra/test/clang-tidy/checkers/cppcoreguidelines-pro-type-vararg.cpp
+++ b/clang-tools-extra/test/clang-tidy/checkers/cppcoreguidelines-pro-type-vararg.cpp
@@ -49,3 +49,11 @@
 }
 
 int my_vprintf(const char* format, va_list arg ); // OK to declare function taking va_list
+
+void ignoredBuiltinsTest() {
+  (void)__builtin_assume_aligned(0, 8);
+  (void)__builtin_constant_p(0);
+  (void)__builtin_fpclassify(0, 0, 0, 0, 0, 0.f);
+  (void)__builtin_isinf_sign(0.f);
+  (void)__builtin_prefetch(nullptr);
+}