diff --git a/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp b/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp
--- a/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp
+++ b/clang-tools-extra/clangd/unittests/SymbolCollectorTests.cpp
@@ -1504,6 +1504,30 @@
   EXPECT_THAT(Refs, Contains(Pair(findSymbol(Symbols, "PUNCT").ID, _)));
 }
 
+// Regression test for a crash-bug we used to have.
+TEST_F(SymbolCollectorTest, UndefOfModuleMacro) {
+  auto TU = TestTU::withCode(R"cpp(#include "/bar.h")cpp");
+  TU.AdditionalFiles["/bar.h"] = R"cpp(
+    #include "/foo.h"
+    #undef X
+    )cpp";
+  TU.AdditionalFiles["/foo.h"] = "#define X 1";
+  TU.AdditionalFiles["/module.map"] = R"cpp(
+    module foo {
+     header "/foo.h"
+     export *
+   }
+   )cpp";
+  TU.ExtraArgs.push_back("-fmodules");
+  TU.ExtraArgs.push_back("-fmodule-map-file=/module.map");
+  TU.OverlayRealFileSystem = true;
+
+  TU.build();
+  // We mostly care about not crashing, but verify that we didn't insert garbage
+  // about X too.
+  EXPECT_THAT(TU.headerSymbols(), Not(Contains(QName("X"))));
+}
+
 } // namespace
 } // namespace clangd
 } // namespace clang
diff --git a/clang-tools-extra/clangd/unittests/TestFS.h b/clang-tools-extra/clangd/unittests/TestFS.h
--- a/clang-tools-extra/clangd/unittests/TestFS.h
+++ b/clang-tools-extra/clangd/unittests/TestFS.h
@@ -35,12 +35,21 @@
 public:
   IntrusiveRefCntPtr<llvm::vfs::FileSystem>
   view(llvm::NoneType) const override {
-    return buildTestFS(Files, Timestamps);
+    auto MemFS = buildTestFS(Files, Timestamps);
+    if (!OverlayRealFileSystem)
+      return MemFS;
+    llvm::IntrusiveRefCntPtr<llvm::vfs::OverlayFileSystem> OverlayFileSystem =
+        new llvm::vfs::OverlayFileSystem(llvm::vfs::getRealFileSystem());
+    OverlayFileSystem->pushOverlay(MemFS);
+    return OverlayFileSystem;
   }
 
   // If relative paths are used, they are resolved with testPath().
   llvm::StringMap<std::string> Files;
   llvm::StringMap<time_t> Timestamps;
+  // If true, real file system will be used as fallback for the in-memory one.
+  // This is useful for testing module support.
+  bool OverlayRealFileSystem = false;
 };
 
 // A Compilation database that returns a fixed set of compile flags.
diff --git a/clang-tools-extra/clangd/unittests/TestTU.h b/clang-tools-extra/clangd/unittests/TestTU.h
--- a/clang-tools-extra/clangd/unittests/TestTU.h
+++ b/clang-tools-extra/clangd/unittests/TestTU.h
@@ -66,6 +66,10 @@
   // Simulate a header guard of the header (using an #import directive).
   bool ImplicitHeaderGuard = true;
 
+  // Whether to use overlay the TestFS over the real filesystem. This is
+  // required for use of modules.
+  bool OverlayRealFileSystem = false;
+
   // By default, build() will report Error diagnostics as GTest errors.
   // Suppress this behavior by adding an 'error-ok' comment to the code.
   ParsedAST build() const;
diff --git a/clang-tools-extra/clangd/unittests/TestTU.cpp b/clang-tools-extra/clangd/unittests/TestTU.cpp
--- a/clang-tools-extra/clangd/unittests/TestTU.cpp
+++ b/clang-tools-extra/clangd/unittests/TestTU.cpp
@@ -54,6 +54,8 @@
   Inputs.CompileCommand.Filename = FullFilename;
   Inputs.CompileCommand.Directory = testRoot();
   Inputs.Contents = Code;
+  if (OverlayRealFileSystem)
+    FS.OverlayRealFileSystem = true;
   Inputs.TFS = &FS;
   Inputs.Opts = ParseOptions();
   Inputs.Opts.BuildRecoveryAST = true;
diff --git a/clang/lib/Index/IndexingAction.cpp b/clang/lib/Index/IndexingAction.cpp
--- a/clang/lib/Index/IndexingAction.cpp
+++ b/clang/lib/Index/IndexingAction.cpp
@@ -165,11 +165,20 @@
 static void indexPreprocessorMacros(const Preprocessor &PP,
                                     IndexDataConsumer &DataConsumer) {
   for (const auto &M : PP.macros())
-    if (MacroDirective *MD = M.second.getLatest())
+    if (MacroDirective *MD = M.second.getLatest()) {
+      auto *MI = MD->getMacroInfo();
+      // When using modules, it may happen that we find #undef of a macro that
+      // was defined in another module. In such case, MI may be nullptr, since
+      // we only look for macro definitions in the current TU. In that case,
+      // there is nothing to index.
+      if (!MI)
+        continue;
+
       DataConsumer.handleMacroOccurrence(
           M.first, MD->getMacroInfo(),
           static_cast<unsigned>(index::SymbolRole::Definition),
           MD->getLocation());
+    }
 }
 
 void index::indexASTUnit(ASTUnit &Unit, IndexDataConsumer &DataConsumer,