diff --git a/llvm/lib/Transforms/Scalar/GVN.cpp b/llvm/lib/Transforms/Scalar/GVN.cpp
--- a/llvm/lib/Transforms/Scalar/GVN.cpp
+++ b/llvm/lib/Transforms/Scalar/GVN.cpp
@@ -931,6 +931,17 @@
   return false;
 }
 
+/// Assuming To can be reached from both From and Between, does Between lie on
+/// every path from From to To?
+static bool liesBetween(const Instruction *From, Instruction *Between,
+                        const Instruction *To, DominatorTree *DT) {
+  if (From->getParent() == Between->getParent())
+    return DT->dominates(From, Between);
+  SmallSet<BasicBlock *, 1> Exclusion;
+  Exclusion.insert(Between->getParent());
+  return !isPotentiallyReachable(From, To, &Exclusion, DT);
+}
+
 /// Try to locate the three instruction involved in a missed
 /// load-elimination case that is due to an intervening store.
 static void reportMayClobberedLoad(LoadInst *Load, MemDepResult DepInfo,
@@ -944,17 +955,46 @@
   R << "load of type " << NV("Type", Load->getType()) << " not eliminated"
     << setExtraArgs();
 
-  for (auto *U : Load->getPointerOperand()->users())
+  for (auto *U : Load->getPointerOperand()->users()) {
     if (U != Load && (isa<LoadInst>(U) || isa<StoreInst>(U)) &&
+        cast<Instruction>(U)->getFunction() == Load->getFunction() &&
         DT->dominates(cast<Instruction>(U), Load)) {
-      // FIXME: for now give up if there are multiple memory accesses that
-      // dominate the load.  We need further analysis to decide which one is
-      // that we're forwarding from.
-      if (OtherAccess)
-        OtherAccess = nullptr;
-      else
+      // Use the most immediately dominating value
+      if (OtherAccess) {
+        if (DT->dominates(cast<Instruction>(OtherAccess), cast<Instruction>(U)))
+          OtherAccess = U;
+        else
+          assert(DT->dominates(cast<Instruction>(U),
+                               cast<Instruction>(OtherAccess)));
+      } else
         OtherAccess = U;
     }
+  }
+
+  if (!OtherAccess) {
+    // There is no dominating use, check if we can find a closest non-dominating
+    // use that lies between any other potentially available use and Load.
+    for (auto *U : Load->getPointerOperand()->users()) {
+      if (U != Load && (isa<LoadInst>(U) || isa<StoreInst>(U)) &&
+          cast<Instruction>(U)->getFunction() == Load->getFunction() &&
+          isPotentiallyReachable(cast<Instruction>(U), Load, nullptr, DT)) {
+        if (OtherAccess) {
+          if (liesBetween(cast<Instruction>(OtherAccess), cast<Instruction>(U),
+                          Load, DT)) {
+            OtherAccess = U;
+          } else if (!liesBetween(cast<Instruction>(U),
+                                  cast<Instruction>(OtherAccess), Load, DT)) {
+            // These uses are both partially available at Load were it not for
+            // the clobber, but neither lies strictly after the other.
+            OtherAccess = nullptr;
+            break;
+          } // else: keep current OtherAccess since it lies between U and Load
+        } else {
+          OtherAccess = U;
+        }
+      }
+    }
+  }
 
   if (OtherAccess)
     R << " in favor of " << NV("OtherAccess", OtherAccess);
diff --git a/llvm/test/Transforms/GVN/opt-remarks-multiple-users.ll b/llvm/test/Transforms/GVN/opt-remarks-multiple-users.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/GVN/opt-remarks-multiple-users.ll
@@ -0,0 +1,137 @@
+; RUN: opt < %s -gvn -o /dev/null  -pass-remarks-output=%t -S
+; RUN: cat %t | FileCheck %s
+
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: DebugLoc: { File: '/tmp/s.c', Line: 2, Column: 2 }
+; CHECK-NEXT: Function:        multipleUsers
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     store
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 1, Column: 1 }
+; CHECK-NEXT: ...
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: DebugLoc: { File: '/tmp/s.c', Line: 4, Column: 4 }
+; CHECK-NEXT: Function:        multipleUsers
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     load
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 2, Column: 2 }
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 3, Column: 3 }
+; CHECK-NEXT: ...
+
+; ModuleID = 'bugpoint-reduced-simplified.bc'
+source_filename = "gvn-test.c"
+target datalayout = "e-m:e-p270:32:32-p271:32:32-p272:64:64-i64:64-f80:128-n8:16:32:64-S128"
+target triple = "x86_64-unknown-linux-gnu"
+
+; Tests that a last clobbering use can be determined even in the presence of
+; multiple users, given that one of them lies on a path between every other
+; potentially clobbering use and the load.
+
+define dso_local void @multipleUsers(i32* %a, i32 %b) local_unnamed_addr #0 {
+entry:
+  store i32 %b, i32* %a, align 4
+  tail call void @clobberingFunc() #1, !dbg !10
+  %0 = load i32, i32* %a, align 4, !dbg !11
+  tail call void @clobberingFunc() #1, !dbg !12
+  %1 = load i32, i32* %a, align 4, !dbg !13
+  %add2 = add nsw i32 %1, %0
+  ret void
+}
+
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: DebugLoc: { File: '/tmp/s.c', Line: 2, Column: 2 }
+; CHECK-NEXT: Function:        multipleUsers2
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     store
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 1, Column: 1 }
+; CHECK-NEXT: ...
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: DebugLoc: { File: '/tmp/s.c', Line: 4, Column: 4 }
+; CHECK-NEXT: Function:        multipleUsers2
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     load
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 2, Column: 2 }
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 3, Column: 3 }
+; CHECK-NEXT: ...
+
+; Ignore uses in other functions
+
+define dso_local void @multipleUsers2(i32 %b) local_unnamed_addr #0 {
+entry:
+  store i32 %b, i32* @g, align 4
+  tail call void @clobberingFunc() #1, !dbg !15
+  %0 = load i32, i32* @g, align 4, !dbg !16
+  tail call void @clobberingFunc() #1, !dbg !17
+  %1 = load i32, i32* @g, align 4, !dbg !18
+  %add3 = add nsw i32 %1, %0
+  ret void
+}
+
+declare dso_local void @clobberingFunc() local_unnamed_addr #0
+
+@g = external global i32
+
+define dso_local void @globalUser(i32 %b) local_unnamed_addr #0 {
+entry:
+  store i32 %b, i32* @g, align 4
+  ret void
+}
+
+
+attributes #0 = { "use-soft-float"="false" }
+attributes #1 = { nounwind }
+
+!llvm.dbg.cu = !{!1}
+!llvm.module.flags = !{!4, !5, !6}
+!llvm.ident = !{!0}
+
+!0 = !{!"clang version 10.0.0 (git@github.com:llvm/llvm-project.git a2f6ae9abffcba260c22bb235879f0576bf3b783)"}
+!1 = distinct !DICompileUnit(language: DW_LANG_C99, file: !2, producer: "clang version 4.0.0 (trunk 282540) (llvm/trunk 282542)", isOptimized: true, runtimeVersion: 0, emissionKind: LineTablesOnly, enums: !3)
+!2 = !DIFile(filename: "/tmp/s.c", directory: "/tmp")
+!3 = !{}
+!4 = !{i32 2, !"Dwarf Version", i32 4}
+!5 = !{i32 2, !"Debug Info Version", i32 3}
+!6 = !{i32 1, !"PIC Level", i32 2}
+!8 = distinct !DISubprogram(name: "multipleUsers", scope: !2, file: !2, line: 1, type: !9, isLocal: false, isDefinition: true, scopeLine: 1, isOptimized: true, unit: !1, retainedNodes: !3)
+!9 = !DISubroutineType(types: !3)
+!10 = !DILocation(line: 1, column: 1, scope: !8)
+!11 = !DILocation(line: 2, column: 2, scope: !8)
+!12 = !DILocation(line: 3, column: 3, scope: !8)
+!13 = !DILocation(line: 4, column: 4, scope: !8)
+!14 = distinct !DISubprogram(name: "multipleUsers2", scope: !2, file: !2, line: 2, type: !9, isLocal: false, isDefinition: true, scopeLine: 1, isOptimized: true, unit: !1, retainedNodes: !3)
+!15 = !DILocation(line: 1, column: 1, scope: !14)
+!16 = !DILocation(line: 2, column: 2, scope: !14)
+!17 = !DILocation(line: 3, column: 3, scope: !14)
+!18 = !DILocation(line: 4, column: 4, scope: !14)
+
diff --git a/llvm/test/Transforms/GVN/opt-remarks-non-dominating.ll b/llvm/test/Transforms/GVN/opt-remarks-non-dominating.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/GVN/opt-remarks-non-dominating.ll
@@ -0,0 +1,206 @@
+; RUN: opt < %s -gvn -o /dev/null  -pass-remarks-output=%t -S
+; RUN: cat %t | FileCheck %s
+
+
+; ModuleID = 'bugpoint-reduced-simplified.bc'
+source_filename = "gvn-test.c"
+target datalayout = "e-m:e-p270:32:32-p271:32:32-p272:64:64-i64:64-f80:128-n8:16:32:64-S128"
+target triple = "x86_64-unknown-linux-gnu"
+
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: Function:        nonDominating1
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     store
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT: ...
+
+; Confirm that the partial redundancy being clobbered by the call to
+; clobberingFunc() between store and load is identified.
+
+define dso_local void @nonDominating1(i32* %a, i1 %cond, i32 %b) local_unnamed_addr #0 {
+entry:
+  br i1 %cond, label %if.then, label %if.end
+
+if.then:                                          ; preds = %entry
+  store i32 %b, i32* %a, align 4
+  br label %if.end
+
+if.end:                                           ; preds = %if.then, %entry
+  tail call void @clobberingFunc() #1
+  %0 = load i32, i32* %a, align 4
+  %mul2 = shl nsw i32 %0, 1
+  store i32 %mul2, i32* %a, align 4
+  ret void
+}
+
+declare dso_local void @clobberingFunc() local_unnamed_addr #0
+
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: DebugLoc:        { File: '/tmp/s.c', Line: 3, Column: 3 }
+; CHECK-NEXT: Function:        nonDominating2
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     load
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 1, Column: 1 }
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 2, Column: 2 }
+; CHECK-NEXT: ...
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: DebugLoc:        { File: '/tmp/s.c', Line: 5, Column: 5 }
+; CHECK-NEXT: Function:        nonDominating2
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     load
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 3, Column: 3 }
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT:     DebugLoc: { File: '/tmp/s.c', Line: 4, Column: 4 }
+; CHECK-NEXT: ...
+
+; More complex version of nonDominating1(), this time with loads. The values
+; already loaded into %0 and %1 cannot replace %2 due to clobbering calls.
+; %1 is not clobbered by the first call however, and %0 is irrelevant for the
+; second one since %1 is more recently available.
+
+define dso_local void @nonDominating2(i32* %a, i1 %cond) local_unnamed_addr #0 {
+entry:
+  br i1 %cond, label %if.then, label %if.end5
+
+if.then:                                          ; preds = %entry
+  %0 = load i32, i32* %a, align 4, !dbg !14
+  %mul = mul nsw i32 %0, 10
+  tail call void @clobberingFunc() #1, !dbg !15
+  %1 = load i32, i32* %a, align 4, !dbg !16
+  %mul3 = mul nsw i32 %1, 5
+  tail call void @clobberingFunc() #1, !dbg !17
+  br label %if.end5
+
+if.end5:                                          ; preds = %if.then, %entry
+  %2 = load i32, i32* %a, align 4, !dbg !18
+  %mul9 = shl nsw i32 %2, 1
+  store i32 %mul9, i32* %a, align 4
+  ret void
+}
+
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: Function:        nonDominating3
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT: ...
+
+; The two stores are both partially available at %0 (were it not for the
+; clobbering call), however neither is strictly more recent than the other, so
+; no attempt is made to identify what value could have potentially been reused
+; otherwise. Just report that the load cannot be eliminated.
+
+define dso_local void @nonDominating3(i32* %a, i32 %b, i32 %c, i1 %cond) local_unnamed_addr #0 {
+entry:
+  br i1 %cond, label %if.end5.sink.split, label %if.else
+
+if.else:                                          ; preds = %entry
+  store i32 %b, i32* %a, align 4
+  br label %if.end5
+
+if.end5.sink.split:                               ; preds = %entry
+  store i32 %c, i32* %a, align 4
+  br label %if.end5
+
+if.end5:                                          ; preds = %if.end5.sink.split, %if.else
+  tail call void @clobberingFunc() #1
+  %0 = load i32, i32* %a, align 4
+  %mul7 = shl nsw i32 %0, 1
+  ret void
+}
+
+; CHECK:      --- !Missed
+; CHECK-NEXT: Pass:            gvn
+; CHECK-NEXT: Name:            LoadClobbered
+; CHECK-NEXT: Function:        nonDominating4
+; CHECK-NEXT: Args:
+; CHECK-NEXT:   - String:          'load of type '
+; CHECK-NEXT:   - Type:            i32
+; CHECK-NEXT:   - String:          ' not eliminated'
+; CHECK-NEXT:   - String:          ' in favor of '
+; CHECK-NEXT:   - OtherAccess:     store
+; CHECK-NEXT:   - String:          ' because it is clobbered by '
+; CHECK-NEXT:   - ClobberedBy:     call
+; CHECK-NEXT: ...
+
+; Make sure isPotentiallyReachable() is not called for an instruction
+; outside the current function, as it will cause a crash.
+
+define dso_local void @nonDominating4(i1 %cond, i32 %b) local_unnamed_addr #0 {
+entry:
+  br i1 %cond, label %if.then, label %if.end
+
+if.then:                                          ; preds = %entry
+  store i32 %b, i32* @g, align 4
+  br label %if.end
+
+if.end:                                           ; preds = %if.then, %entry
+  tail call void @clobberingFunc() #1
+  %0 = load i32, i32* @g, align 4
+  %mul2 = shl nsw i32 %0, 1
+  store i32 %mul2, i32* @g, align 4
+  ret void
+}
+
+@g = external global i32
+
+define dso_local void @globalUser(i32 %b) local_unnamed_addr #0 {
+entry:
+  store i32 %b, i32* @g, align 4
+  ret void
+}
+
+attributes #0 = { "use-soft-float"="false" }
+attributes #1 = { nounwind }
+
+!llvm.ident = !{!0}
+!llvm.dbg.cu = !{!1}
+!llvm.module.flags = !{!4, !5, !6}
+
+!0 = !{!"clang version 10.0.0 (git@github.com:llvm/llvm-project.git a2f6ae9abffcba260c22bb235879f0576bf3b783)"}
+
+!1 = distinct !DICompileUnit(language: DW_LANG_C99, file: !2, producer: "clang version 4.0.0 (trunk 282540) (llvm/trunk 282542)", isOptimized: true, runtimeVersion: 0, emissionKind: LineTablesOnly, enums: !3)
+!2 = !DIFile(filename: "/tmp/s.c", directory: "/tmp")
+!3 = !{}
+!4 = !{i32 2, !"Dwarf Version", i32 4}
+!5 = !{i32 2, !"Debug Info Version", i32 3}
+!6 = !{i32 1, !"PIC Level", i32 2}
+!8 = distinct !DISubprogram(name: "nonDominating2", scope: !2, file: !2, line: 1, type: !9, isLocal: false, isDefinition: true, scopeLine: 1, isOptimized: true, unit: !1, retainedNodes: !3)
+!9 = !DISubroutineType(types: !10)
+!10 = !{null, !11, !12, !12, !13}
+!11 = !DIDerivedType(tag: DW_TAG_pointer_type, baseType: !12, size: 64)
+!12 = !DIBasicType(name: "int", size: 32, encoding: DW_ATE_signed)
+!13 = !DIBasicType(name: "_Bool", size: 8, encoding: DW_ATE_boolean)
+!14 = !DILocation(line: 1, column: 1, scope: !8)
+!15 = !DILocation(line: 2, column: 2, scope: !8)
+!16 = !DILocation(line: 3, column: 3, scope: !8)
+!17 = !DILocation(line: 4, column: 4, scope: !8)
+!18 = !DILocation(line: 5, column: 5, scope: !8)
+