diff --git a/clang/lib/Basic/Targets/AMDGPU.cpp b/clang/lib/Basic/Targets/AMDGPU.cpp
--- a/clang/lib/Basic/Targets/AMDGPU.cpp
+++ b/clang/lib/Basic/Targets/AMDGPU.cpp
@@ -363,4 +363,17 @@
   copyAuxTarget(Aux);
   LongDoubleFormat = SaveLongDoubleFormat;
   Float128Format = SaveFloat128Format;
+  // For certain builtin types support on the host target, claim they are
+  // support to pass the compilation of the host code during the device-side
+  // compilation.
+  // FIXME: As the side effect, we also accept `__float128` uses in the device
+  // code. To rejct these builtin types supported in the host target but not in
+  // the device target, one approach would support `device_builtin` attribute
+  // so that we could tell the device builtin types from the host ones. The
+  // also solves the different representations of the same builtin type, such
+  // as `size_t` in the MSVC environment.
+  if (Aux->hasFloat128Type()) {
+    HasFloat128 = true;
+    Float128Format = DoubleFormat;
+  }
 }
diff --git a/clang/test/SemaCUDA/amdgpu-f128.cu b/clang/test/SemaCUDA/amdgpu-f128.cu
new file mode 100644
--- /dev/null
+++ b/clang/test/SemaCUDA/amdgpu-f128.cu
@@ -0,0 +1,4 @@
+// RUN: %clang_cc1 -triple amdgcn-amd-amdhsa -aux-triple x86_64-unknown-linux-gnu -fcuda-is-device -fsyntax-only -verify %s
+
+// expected-no-diagnostics
+typedef __float128 f128_t;