diff --git a/clang/test/CodeGen/catch-implicit-conversions-basics-negatives.c b/clang/test/CodeGen/catch-implicit-conversions-basics-negatives.c
--- a/clang/test/CodeGen/catch-implicit-conversions-basics-negatives.c
+++ b/clang/test/CodeGen/catch-implicit-conversions-basics-negatives.c
@@ -1,4 +1,4 @@
-// RUN: %clang_cc1 -fsanitize=implicit-unsigned-integer-truncation,implicit-signed-integer-truncation,implicit-integer-sign-change -fsanitize-recover=implicit-unsigned-integer-truncation,implicit-signed-integer-truncation,implicit-integer-sign-change -emit-llvm %s -o - -triple x86_64-linux-gnu | FileCheck %s -implicit-check-not="call void @__ubsan_handle_implicit_conversion" --check-prefixes=CHECK
+// RUN: %clang_cc1 -fsanitize=implicit-unsigned-integer-truncation,implicit-signed-integer-truncation,implicit-integer-sign-change -fsanitize-recover=implicit-unsigned-integer-truncation,implicit-signed-integer-truncation,implicit-integer-sign-change -emit-llvm %s -o - -triple x86_64-linux-gnu | FileCheck %s -implicit-check-not="call void @__ubsan_handle_implicit_conversion"
 
 // If we have an enum, it will be promoted to an unsigned integer.
 // But both types are unsigned, and have same bitwidth.
diff --git a/llvm/include/llvm/Support/FileCheck.h b/llvm/include/llvm/Support/FileCheck.h
--- a/llvm/include/llvm/Support/FileCheck.h
+++ b/llvm/include/llvm/Support/FileCheck.h
@@ -31,6 +31,7 @@
   bool AllowEmptyInput = false;
   bool MatchFullLines = false;
   bool IgnoreCase = false;
+  bool IsDefaultCheckPrefix = false;
   bool EnableVarScope = false;
   bool AllowDeprecatedDagOverlap = false;
   bool Verbose = false;
diff --git a/llvm/lib/Support/FileCheck.cpp b/llvm/lib/Support/FileCheck.cpp
--- a/llvm/lib/Support/FileCheck.cpp
+++ b/llvm/lib/Support/FileCheck.cpp
@@ -1305,6 +1305,7 @@
   // found.
   unsigned LineNumber = 1;
 
+  bool FoundUsedPrefix = false;
   while (1) {
     Check::FileCheckType CheckTy;
 
@@ -1315,6 +1316,8 @@
         FindFirstMatchingPrefix(PrefixRE, Buffer, LineNumber, CheckTy);
     if (UsedPrefix.empty())
       break;
+    FoundUsedPrefix = true;
+
     assert(UsedPrefix.data() == Buffer.data() &&
            "Failed to move Buffer's start forward, or pointed prefix outside "
            "of the buffer!");
@@ -1398,16 +1401,10 @@
     DagNotMatches = ImplicitNegativeChecks;
   }
 
-  // Add an EOF pattern for any trailing --implicit-check-not/CHECK-DAG/-NOTs,
-  // and use the first prefix as a filler for the error message.
-  if (!DagNotMatches.empty()) {
-    CheckStrings->emplace_back(
-        Pattern(Check::CheckEOF, PatternContext.get(), LineNumber + 1),
-        *Req.CheckPrefixes.begin(), SMLoc::getFromPointer(Buffer.data()));
-    std::swap(DagNotMatches, CheckStrings->back().DagNotStrings);
-  }
-
-  if (CheckStrings->empty()) {
+  // When there are no used prefixes we report an error except in the case that
+  // no prefix is specified explicitly but -implicit-check-not is specified.
+  if (!FoundUsedPrefix &&
+      (ImplicitNegativeChecks.empty() || !Req.IsDefaultCheckPrefix)) {
     errs() << "error: no check strings found with prefix"
            << (Req.CheckPrefixes.size() > 1 ? "es " : " ");
     auto I = Req.CheckPrefixes.begin();
@@ -1423,6 +1420,15 @@
     return true;
   }
 
+  // Add an EOF pattern for any trailing --implicit-check-not/CHECK-DAG/-NOTs,
+  // and use the first prefix as a filler for the error message.
+  if (!DagNotMatches.empty()) {
+    CheckStrings->emplace_back(
+        Pattern(Check::CheckEOF, PatternContext.get(), LineNumber + 1),
+        *Req.CheckPrefixes.begin(), SMLoc::getFromPointer(Buffer.data()));
+    std::swap(DagNotMatches, CheckStrings->back().DagNotStrings);
+  }
+
   return false;
 }
 
@@ -1888,8 +1894,10 @@
 Regex FileCheck::buildCheckPrefixRegex() {
   // I don't think there's a way to specify an initial value for cl::list,
   // so if nothing was specified, add the default
-  if (Req.CheckPrefixes.empty())
+  if (Req.CheckPrefixes.empty()) {
     Req.CheckPrefixes.push_back("CHECK");
+    Req.IsDefaultCheckPrefix = true;
+  }
 
   // We already validated the contents of CheckPrefixes so just concatenate
   // them as alternatives.
diff --git a/llvm/test/FileCheck/implicit-check-not.txt b/llvm/test/FileCheck/implicit-check-not.txt
--- a/llvm/test/FileCheck/implicit-check-not.txt
+++ b/llvm/test/FileCheck/implicit-check-not.txt
@@ -1,4 +1,16 @@
 ; RUN: sed 's#^;.*##' %s | FileCheck -check-prefix=CHECK-PASS -implicit-check-not=warning: %s
+
+; Check we report an error when an unknown prefix is used together with `-implicit-check-not`.
+; RUN: sed 's#^;.*##' %s | %ProtectFileCheckOutput not FileCheck -check-prefix=UNKNOWN-PREFIX -implicit-check-not=abc %s 2>&1 | FileCheck %s -DPREFIX=UNKNOWN-PREFIX -check-prefix CHECK-PREFIX-ERROR
+; CHECK-PREFIX-ERROR: error: no check strings found with prefix '[[PREFIX]]:'
+
+; Check we report an error when the "CHECK" prefix is used explicitly with `-implicit-check-not`, but not present in the input.
+; RUN: sed 's#^;.*##' %s | %ProtectFileCheckOutput not FileCheck -check-prefix=CHECK -implicit-check-not=abc %s 2>&1 | FileCheck %s -DPREFIX=CHECK -check-prefix CHECK-PREFIX-ERROR
+
+; Check we allow using `-implicit-check-not` when there is no `-check-prefix` specified and there
+; is no default `CHECK` line in an input.
+; RUN: sed 's#^;.*##' %s | FileCheck -implicit-check-not="unique_string" %s
+
 ; RUN: sed 's#^;.*##' %s | %ProtectFileCheckOutput not FileCheck -check-prefix=CHECK-FAIL1 -implicit-check-not=warning: %s 2>&1 | FileCheck %s -check-prefix CHECK-ERROR1
 ; RUN: sed 's#^;.*##' %s | %ProtectFileCheckOutput not FileCheck -check-prefix=CHECK-FAIL2 -implicit-check-not=warning: %s 2>&1 | FileCheck %s -check-prefix CHECK-ERROR2
 ; RUN: sed 's#^;.*##' %s | %ProtectFileCheckOutput not FileCheck -check-prefix=CHECK-FAIL3 -implicit-check-not=warning: %s 2>&1 | FileCheck %s -check-prefix CHECK-ERROR3
diff --git a/llvm/test/tools/llvm-objcopy/MachO/strip-debug.test b/llvm/test/tools/llvm-objcopy/MachO/strip-debug.test
--- a/llvm/test/tools/llvm-objcopy/MachO/strip-debug.test
+++ b/llvm/test/tools/llvm-objcopy/MachO/strip-debug.test
@@ -3,7 +3,7 @@
 # RUN: yaml2obj %p/Inputs/strip-all-with-dwarf.yaml -o %t
 
 # RUN: llvm-objcopy --strip-debug %t %t.stripped
-# RUN: llvm-readobj --sections %t.stripped | FileCheck /dev/null --check-prefix=NODWARF \
+# RUN: llvm-readobj --sections %t.stripped | FileCheck /dev/null \
 # RUN:   --implicit-check-not='Name: __debug' --implicit-check-not='Name: __apple'
 
 ## Make sure that all symbols are kept.