Index: llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
===================================================================
--- llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
+++ llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
@@ -143,7 +143,7 @@
     ++NumFastOther;
 
     // Try to preserve debug information attached to the dead instruction.
-    salvageDebugInfo(*DeadInst);
+    salvageDebugInfoOrMarkUndef(*DeadInst);
 
     // This instruction is dead, zap it, in stages.  Start by removing it from
     // MemDep, which needs to know the operands and needs it to be in the
Index: llvm/test/DebugInfo/X86/dead-store-elimination-marks-undef.ll
===================================================================
--- /dev/null
+++ llvm/test/DebugInfo/X86/dead-store-elimination-marks-undef.ll
@@ -0,0 +1,35 @@
+; RUN: opt -mtriple=x86_64-- -S --dse %s  -o - | FileCheck %s
+; Ensure that we can mark a value as undefined when performing dead 
+; store elimination.
+; Bugzilla #45080
+
+@b = common dso_local local_unnamed_addr global i32 0, align 1
+
+define dso_local i32 @main() local_unnamed_addr !dbg !7 {
+  %1 = alloca i32, align 4
+  %2 = load i32, i32* @b, align 1, !dbg !13
+  ; CHECK: call void @llvm.dbg.value(metadata i32 undef
+  call void @llvm.dbg.value(metadata i32 %2, metadata !12, metadata !DIExpression()), !dbg !13
+  store i32 %2, i32* %1, align 4, !dbg !13
+  ret i32 0, !dbg !13
+}
+
+declare void @llvm.dbg.value(metadata, metadata, metadata)
+
+!llvm.dbg.cu = !{!0}
+!llvm.module.flags = !{!3, !4}
+!llvm.ident = !{!6}
+
+!0 = distinct !DICompileUnit(language: DW_LANG_C99, file: !1, producer: "clang version 10.0.0", isOptimized: true, runtimeVersion: 0, emissionKind: FullDebug, enums: !2, globals: !2, nameTableKind: None)
+!1 = !DIFile(filename: "dead-store-elimination-marks-undef.ll", directory: "/temp/bz45080")
+!2 = !{}
+!3 = !{i32 2, !"Dwarf Version", i32 4}
+!4 = !{i32 2, !"Debug Info Version", i32 3}
+!6 = !{!"clang version 10.0.0"}
+!7 = distinct !DISubprogram(name: "main", scope: !1, file: !1, line: 3, type: !8, scopeLine: 3, spFlags: DISPFlagDefinition | DISPFlagOptimized, unit: !0, retainedNodes: !11)
+!8 = !DISubroutineType(types: !9)
+!9 = !{!10}
+!10 = !DIBasicType(name: "int", size: 32, encoding: DW_ATE_signed)
+!11 = !{!12}
+!12 = !DILocalVariable(name: "l_2864", scope: !7, file: !1, line: 4, type: !10)
+!13 = !DILocation(line: 5, column: 12, scope: !7)