diff --git a/llvm/lib/Transforms/Scalar/StructurizeCFG.cpp b/llvm/lib/Transforms/Scalar/StructurizeCFG.cpp
--- a/llvm/lib/Transforms/Scalar/StructurizeCFG.cpp
+++ b/llvm/lib/Transforms/Scalar/StructurizeCFG.cpp
@@ -1013,7 +1013,7 @@
 
   DA = nullptr;
 
-  if (SkipUniformRegions) {
+  if (SkipUniformRegions && !skipRegion(*R)) {
     // TODO: We could probably be smarter here with how we handle sub-regions.
     // We currently rely on the fact that metadata is set by earlier invocations
     // of the pass on sub-regions, and that this metadata doesn't get lost --