diff --git a/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt b/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt
--- a/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt
+++ b/openmp/libomptarget/deviceRTLs/nvptx/CMakeLists.txt
@@ -50,6 +50,7 @@
   # propagating host flags.
   set(CUDA_PROPAGATE_HOST_FLAGS OFF)
 
+  # Note: These files are also listed in unity.cu
   set(cuda_src_files
       ${devicertl_common_directory}/src/cancel.cu
       ${devicertl_common_directory}/src/critical.cu
@@ -95,7 +96,7 @@
   set(CUDA_SEPARABLE_COMPILATION ON)
   list(APPEND CUDA_NVCC_FLAGS -I${devicertl_base_directory}
                               -I${devicertl_nvptx_directory}/src)
-  cuda_add_library(omptarget-nvptx STATIC ${cuda_src_files} ${omp_data_objects}
+  cuda_add_library(omptarget-nvptx STATIC unity.cu
       OPTIONS ${CUDA_ARCH} ${CUDA_DEBUG})
 
   # Install device RTL under the lib destination folder.
diff --git a/openmp/libomptarget/deviceRTLs/nvptx/unity.cu b/openmp/libomptarget/deviceRTLs/nvptx/unity.cu
new file mode 100644
--- /dev/null
+++ b/openmp/libomptarget/deviceRTLs/nvptx/unity.cu
@@ -0,0 +1,27 @@
+//===------ unity.cu - Unity build of NVPTX deviceRTL ------------ CUDA -*-===//
+//
+// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+// See https://llvm.org/LICENSE.txt for license information.
+// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+//
+//===----------------------------------------------------------------------===//
+//
+// Support compilers, specifically NVCC, which have not implemented link time
+// optimisation. This removes the runtime cost of moving inline functions into
+// source files in exchange for negligible build overhead.
+//
+//===----------------------------------------------------------------------===//
+
+#include "common/src/cancel.cu"
+#include "common/src/critical.cu"
+#include "common/src/data_sharing.cu"
+#include "common/src/libcall.cu"
+#include "common/src/loop.cu"
+#include "common/src/omp_data.cu"
+#include "common/src/omptarget.cu"
+#include "common/src/parallel.cu"
+#include "common/src/reduction.cu"
+#include "common/src/support.cu"
+#include "common/src/sync.cu"
+#include "common/src/task.cu"
+#include "src/target_impl.cu"