diff --git a/llvm/include/llvm/IR/IRBuilder.h b/llvm/include/llvm/IR/IRBuilder.h
--- a/llvm/include/llvm/IR/IRBuilder.h
+++ b/llvm/include/llvm/IR/IRBuilder.h
@@ -1068,28 +1068,6 @@
                         NormalDest, UnwindDest, Args, Name);
   }
 
-  // Deprecated [opaque pointer types]
-  InvokeInst *CreateInvoke(Value *Callee, BasicBlock *NormalDest,
-                           BasicBlock *UnwindDest, ArrayRef<Value *> Args,
-                           ArrayRef<OperandBundleDef> OpBundles,
-                           const Twine &Name = "") {
-    return CreateInvoke(
-        cast<FunctionType>(
-            cast<PointerType>(Callee->getType())->getElementType()),
-        Callee, NormalDest, UnwindDest, Args, OpBundles, Name);
-  }
-
-  // Deprecated [opaque pointer types]
-  InvokeInst *CreateInvoke(Value *Callee, BasicBlock *NormalDest,
-                           BasicBlock *UnwindDest,
-                           ArrayRef<Value *> Args = None,
-                           const Twine &Name = "") {
-    return CreateInvoke(
-        cast<FunctionType>(
-            cast<PointerType>(Callee->getType())->getElementType()),
-        Callee, NormalDest, UnwindDest, Args, Name);
-  }
-
   /// \brief Create a callbr instruction.
   CallBrInst *CreateCallBr(FunctionType *Ty, Value *Callee,
                            BasicBlock *DefaultDest,
@@ -2488,23 +2466,6 @@
                       OpBundles, Name, FPMathTag);
   }
 
-  // Deprecated [opaque pointer types]
-  CallInst *CreateCall(Value *Callee, ArrayRef<Value *> Args = None,
-                       const Twine &Name = "", MDNode *FPMathTag = nullptr) {
-    return CreateCall(
-        cast<FunctionType>(Callee->getType()->getPointerElementType()), Callee,
-        Args, Name, FPMathTag);
-  }
-
-  // Deprecated [opaque pointer types]
-  CallInst *CreateCall(Value *Callee, ArrayRef<Value *> Args,
-                       ArrayRef<OperandBundleDef> OpBundles,
-                       const Twine &Name = "", MDNode *FPMathTag = nullptr) {
-    return CreateCall(
-        cast<FunctionType>(Callee->getType()->getPointerElementType()), Callee,
-        Args, OpBundles, Name, FPMathTag);
-  }
-
   CallInst *CreateConstrainedFPCall(
       Function *Callee, ArrayRef<Value *> Args, const Twine &Name = "",
       Optional<fp::RoundingMode> Rounding = None,
diff --git a/llvm/include/llvm/IR/Instructions.h b/llvm/include/llvm/IR/Instructions.h
--- a/llvm/include/llvm/IR/Instructions.h
+++ b/llvm/include/llvm/IR/Instructions.h
@@ -199,40 +199,6 @@
            MaybeAlign Align, AtomicOrdering Order, SyncScope::ID SSID,
            BasicBlock *InsertAtEnd);
 
-  // Deprecated [opaque pointer types]
-  explicit LoadInst(Value *Ptr, const Twine &NameStr = "",
-                    Instruction *InsertBefore = nullptr)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 InsertBefore) {}
-  LoadInst(Value *Ptr, const Twine &NameStr, BasicBlock *InsertAtEnd)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 InsertAtEnd) {}
-  LoadInst(Value *Ptr, const Twine &NameStr, bool isVolatile,
-           Instruction *InsertBefore = nullptr)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 isVolatile, InsertBefore) {}
-  LoadInst(Value *Ptr, const Twine &NameStr, bool isVolatile,
-           BasicBlock *InsertAtEnd)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 isVolatile, InsertAtEnd) {}
-  LoadInst(Value *Ptr, const Twine &NameStr, bool isVolatile, MaybeAlign Align,
-           Instruction *InsertBefore = nullptr)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 isVolatile, Align, InsertBefore) {}
-  LoadInst(Value *Ptr, const Twine &NameStr, bool isVolatile, MaybeAlign Align,
-           BasicBlock *InsertAtEnd)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 isVolatile, Align, InsertAtEnd) {}
-  LoadInst(Value *Ptr, const Twine &NameStr, bool isVolatile, MaybeAlign Align,
-           AtomicOrdering Order, SyncScope::ID SSID = SyncScope::System,
-           Instruction *InsertBefore = nullptr)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 isVolatile, Align, Order, SSID, InsertBefore) {}
-  LoadInst(Value *Ptr, const Twine &NameStr, bool isVolatile, MaybeAlign Align,
-           AtomicOrdering Order, SyncScope::ID SSID, BasicBlock *InsertAtEnd)
-      : LoadInst(Ptr->getType()->getPointerElementType(), Ptr, NameStr,
-                 isVolatile, Align, Order, SSID, InsertAtEnd) {}
-
   /// Return true if this is a load from a volatile memory location.
   bool isVolatile() const { return getSubclassDataFromInstruction() & 1; }
 
@@ -1543,58 +1509,6 @@
                   NameStr, InsertAtEnd);
   }
 
-  // Deprecated [opaque pointer types]
-  static CallInst *Create(Value *Func, const Twine &NameStr = "",
-                          Instruction *InsertBefore = nullptr) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, NameStr, InsertBefore);
-  }
-
-  // Deprecated [opaque pointer types]
-  static CallInst *Create(Value *Func, ArrayRef<Value *> Args,
-                          const Twine &NameStr,
-                          Instruction *InsertBefore = nullptr) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, Args, NameStr, InsertBefore);
-  }
-
-  // Deprecated [opaque pointer types]
-  static CallInst *Create(Value *Func, ArrayRef<Value *> Args,
-                          ArrayRef<OperandBundleDef> Bundles = None,
-                          const Twine &NameStr = "",
-                          Instruction *InsertBefore = nullptr) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, Args, Bundles, NameStr, InsertBefore);
-  }
-
-  // Deprecated [opaque pointer types]
-  static CallInst *Create(Value *Func, const Twine &NameStr,
-                          BasicBlock *InsertAtEnd) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, NameStr, InsertAtEnd);
-  }
-
-  // Deprecated [opaque pointer types]
-  static CallInst *Create(Value *Func, ArrayRef<Value *> Args,
-                          const Twine &NameStr, BasicBlock *InsertAtEnd) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, Args, NameStr, InsertAtEnd);
-  }
-
-  // Deprecated [opaque pointer types]
-  static CallInst *Create(Value *Func, ArrayRef<Value *> Args,
-                          ArrayRef<OperandBundleDef> Bundles,
-                          const Twine &NameStr, BasicBlock *InsertAtEnd) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, Args, Bundles, NameStr, InsertAtEnd);
-  }
-
   /// Create a clone of \p CI with a different set of operand bundles and
   /// insert it before \p InsertPt.
   ///
@@ -3804,49 +3718,6 @@
                   IfException, Args, Bundles, NameStr, InsertAtEnd);
   }
 
-  // Deprecated [opaque pointer types]
-  static InvokeInst *Create(Value *Func, BasicBlock *IfNormal,
-                            BasicBlock *IfException, ArrayRef<Value *> Args,
-                            const Twine &NameStr,
-                            Instruction *InsertBefore = nullptr) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, IfNormal, IfException, Args, None, NameStr,
-                  InsertBefore);
-  }
-
-  // Deprecated [opaque pointer types]
-  static InvokeInst *Create(Value *Func, BasicBlock *IfNormal,
-                            BasicBlock *IfException, ArrayRef<Value *> Args,
-                            ArrayRef<OperandBundleDef> Bundles = None,
-                            const Twine &NameStr = "",
-                            Instruction *InsertBefore = nullptr) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, IfNormal, IfException, Args, Bundles, NameStr,
-                  InsertBefore);
-  }
-
-  // Deprecated [opaque pointer types]
-  static InvokeInst *Create(Value *Func, BasicBlock *IfNormal,
-                            BasicBlock *IfException, ArrayRef<Value *> Args,
-                            const Twine &NameStr, BasicBlock *InsertAtEnd) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, IfNormal, IfException, Args, NameStr, InsertAtEnd);
-  }
-
-  // Deprecated [opaque pointer types]
-  static InvokeInst *Create(Value *Func, BasicBlock *IfNormal,
-                            BasicBlock *IfException, ArrayRef<Value *> Args,
-                            ArrayRef<OperandBundleDef> Bundles,
-                            const Twine &NameStr, BasicBlock *InsertAtEnd) {
-    return Create(cast<FunctionType>(
-                      cast<PointerType>(Func->getType())->getElementType()),
-                  Func, IfNormal, IfException, Args, Bundles, NameStr,
-                  InsertAtEnd);
-  }
-
   /// Create a clone of \p II with a different set of operand bundles and
   /// insert it before \p InsertPt.
   ///