diff --git a/llvm/include/llvm/IR/KnowledgeRetention.h b/llvm/include/llvm/IR/KnowledgeRetention.h
--- a/llvm/include/llvm/IR/KnowledgeRetention.h
+++ b/llvm/include/llvm/IR/KnowledgeRetention.h
@@ -19,6 +19,7 @@
 #include "llvm/IR/Attributes.h"
 #include "llvm/IR/Instruction.h"
 #include "llvm/IR/PassManager.h"
+#include "llvm/IR/Dominators.h"
 #include "llvm/ADT/DenseMap.h"
 
 namespace llvm {
@@ -109,6 +110,8 @@
   Attribute::AttrKind AttrKind = Attribute::None;
   Value *WasOn = nullptr;
   unsigned ArgValue = 0;
+  operator bool() const { return AttrKind != Attribute::None; }
+  static RetainedKnowledge none() { return RetainedKnowledge{}; }
 };
 
 /// Retreive the information help by Assume on the operand at index Idx.
@@ -133,6 +136,19 @@
 /// function returned true.
 bool isAssumeWithEmptyBundle(CallInst &Assume);
 
+/// return true iff U is a Use in an llvm.assume bundle and this use is
+/// associated with any attributes of AttrKinds.
+RetainedKnowledge
+getRetainedKnowledgeFromUse(const Use *U,
+                            ArrayRef<Attribute::AttrKind> AttrKinds);
+
+/// Return true iff the value V has any attribute in AttrKinds in an the operand
+/// bundles of an llvm.assume and matches the Filter predicate.
+RetainedKnowledge getRetainedKnowledgeForValue(
+    const Value *V, ArrayRef<Attribute::AttrKind> AttrKinds,
+    llvm::function_ref<bool(RetainedKnowledge, Instruction *)> Filter =
+        [](RetainedKnowledge, Instruction *) { return true; });
+
 //===----------------------------------------------------------------------===//
 // Utilities for testing
 //===----------------------------------------------------------------------===//
diff --git a/llvm/lib/Analysis/ValueTracking.cpp b/llvm/lib/Analysis/ValueTracking.cpp
--- a/llvm/lib/Analysis/ValueTracking.cpp
+++ b/llvm/lib/Analysis/ValueTracking.cpp
@@ -53,6 +53,7 @@
 #include "llvm/IR/Intrinsics.h"
 #include "llvm/IR/IntrinsicsAArch64.h"
 #include "llvm/IR/IntrinsicsX86.h"
+#include "llvm/IR/KnowledgeRetention.h"
 #include "llvm/IR/LLVMContext.h"
 #include "llvm/IR/Metadata.h"
 #include "llvm/IR/Module.h"
@@ -687,6 +688,19 @@
     return !TrueValues.contains(APInt::getNullValue(CI->getBitWidth()));
   };
 
+  if (Q.CxtI && V->getType()->isPointerTy()) {
+    SmallVector<Attribute::AttrKind, 2> AttrKinds{Attribute::NonNull};
+    if (!llvm::NullPointerIsDefined(Q.CxtI->getFunction(),
+                                    V->getType()->getPointerAddressSpace()))
+      AttrKinds.push_back(Attribute::Dereferenceable);
+
+    if (getRetainedKnowledgeForValue(
+            V, AttrKinds, [&](RetainedKnowledge, Instruction *Assume) {
+              return isValidAssumeForContext(Assume, Q.CxtI, Q.DT);
+            }))
+      return true;
+  }
+
   for (auto &AssumeVH : Q.AC->assumptionsFor(V)) {
     if (!AssumeVH)
       continue;
diff --git a/llvm/lib/IR/KnowledgeRetention.cpp b/llvm/lib/IR/KnowledgeRetention.cpp
--- a/llvm/lib/IR/KnowledgeRetention.cpp
+++ b/llvm/lib/IR/KnowledgeRetention.cpp
@@ -298,6 +298,32 @@
                  });
 }
 
+RetainedKnowledge
+llvm::getRetainedKnowledgeFromUse(const Use *U,
+                                  ArrayRef<Attribute::AttrKind> AttrKinds) {
+  auto *Intr = dyn_cast<IntrinsicInst>(U->getUser());
+  if (!Intr || Intr->getIntrinsicID() != Intrinsic::assume ||
+      &*Intr->args().begin() == U)
+    return RetainedKnowledge::none();
+  RetainedKnowledge RK =
+      getKnowledgeFromOperandInAssume(*Intr, U->getOperandNo());
+  for (auto Attr : AttrKinds)
+    if (Attr == RK.AttrKind)
+      return RK;
+  return RetainedKnowledge::none();
+}
+
+RetainedKnowledge llvm::getRetainedKnowledgeForValue(
+    const Value *V, ArrayRef<Attribute::AttrKind> AttrKinds,
+    llvm::function_ref<bool(RetainedKnowledge, Instruction *)> Filter) {
+  for (auto &U : V->uses()) {
+    if (RetainedKnowledge RK = getRetainedKnowledgeFromUse(&U, AttrKinds))
+      if (Filter(RK, cast<Instruction>(U.getUser())))
+        return RK;
+  }
+  return RetainedKnowledge::none();
+}
+
 PreservedAnalyses AssumeBuilderPass::run(Function &F,
                                          FunctionAnalysisManager &AM) {
   for (Instruction &I : instructions(F))
diff --git a/llvm/lib/Transforms/IPO/Attributor.cpp b/llvm/lib/Transforms/IPO/Attributor.cpp
--- a/llvm/lib/Transforms/IPO/Attributor.cpp
+++ b/llvm/lib/Transforms/IPO/Attributor.cpp
@@ -37,6 +37,7 @@
 #include "llvm/IR/IRBuilder.h"
 #include "llvm/IR/InstIterator.h"
 #include "llvm/IR/IntrinsicInst.h"
+#include "llvm/IR/KnowledgeRetention.h"
 #include "llvm/IR/NoFolder.h"
 #include "llvm/IR/Verifier.h"
 #include "llvm/InitializePasses.h"
@@ -2021,8 +2022,15 @@
       F ? llvm::NullPointerIsDefined(F, PtrTy->getPointerAddressSpace()) : true;
   const DataLayout &DL = A.getInfoCache().getDL();
   if (ImmutableCallSite ICS = ImmutableCallSite(I)) {
-    if (ICS.isBundleOperand(U))
+    if (ICS.isBundleOperand(U)) {
+      if (RetainedKnowledge RK = getRetainedKnowledgeFromUse(
+              U, {Attribute::NonNull, Attribute::Dereferenceable})) {
+        IsNonNull |=
+            (RK.AttrKind == Attribute::NonNull || !NullPointerIsDefined);
+        return RK.ArgValue;
+      }
       return 0;
+    }
 
     if (ICS.isCallee(U)) {
       IsNonNull |= !NullPointerIsDefined;
diff --git a/llvm/test/Analysis/ValueTracking/assume.ll b/llvm/test/Analysis/ValueTracking/assume.ll
--- a/llvm/test/Analysis/ValueTracking/assume.ll
+++ b/llvm/test/Analysis/ValueTracking/assume.ll
@@ -21,9 +21,14 @@
 
 define void @assume_not() {
 ; CHECK-LABEL: @assume_not(
+; CHECK-NEXT:  entry-block:
+; CHECK-NEXT:    [[TMP0:%.*]] = call i1 @get_val()
+; CHECK-NEXT:    [[TMP1:%.*]] = xor i1 [[TMP0]], true
+; CHECK-NEXT:    call void @llvm.assume(i1 [[TMP1]])
+; CHECK-NEXT:    ret void
+;
 entry-block:
   %0 = call i1 @get_val()
-; CHECK: call void @llvm.assume
   %1 = xor i1 %0, true
   call void @llvm.assume(i1 %1)
   ret void
@@ -31,3 +36,92 @@
 
 declare i1 @get_val()
 declare void @llvm.assume(i1)
+
+define dso_local i1 @test1(i32* readonly %0) {
+; CHECK-LABEL: @test1(
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "nonnull"(i32* [[TMP0:%.*]]) ]
+; CHECK-NEXT:    ret i1 false
+;
+  call void @llvm.assume(i1 true) ["nonnull"(i32* %0)]
+  %2 = icmp eq i32* %0, null
+  ret i1 %2
+}
+
+define dso_local i1 @test2(i32* readonly %0) {
+; CHECK-LABEL: @test2(
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "nonnull"(i32* [[TMP0:%.*]]) ]
+; CHECK-NEXT:    ret i1 false
+;
+  %2 = icmp eq i32* %0, null
+  call void @llvm.assume(i1 true) ["nonnull"(i32* %0)]
+  ret i1 %2
+}
+
+define dso_local i32 @test4(i32* readonly %0, i1 %cond) {
+; CHECK-LABEL: @test4(
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "dereferenceable"(i32* [[TMP0:%.*]], i32 4) ]
+; CHECK-NEXT:    br i1 [[COND:%.*]], label [[A:%.*]], label [[B:%.*]]
+; CHECK:       B:
+; CHECK-NEXT:    br label [[A]]
+; CHECK:       A:
+; CHECK-NEXT:    br i1 false, label [[TMP4:%.*]], label [[TMP2:%.*]]
+; CHECK:       2:
+; CHECK-NEXT:    [[TMP3:%.*]] = load i32, i32* [[TMP0]], align 4
+; CHECK-NEXT:    br label [[TMP4]]
+; CHECK:       4:
+; CHECK-NEXT:    [[TMP5:%.*]] = phi i32 [ [[TMP3]], [[TMP2]] ], [ 0, [[A]] ]
+; CHECK-NEXT:    ret i32 [[TMP5]]
+;
+  call void @llvm.assume(i1 true) ["dereferenceable"(i32* %0, i32 4)]
+  br i1 %cond, label %A, label %B
+
+B:
+  br label %A
+
+A:
+  %2 = icmp eq i32* %0, null
+  br i1 %2, label %5, label %3
+
+3:                                                ; preds = %1
+  %4 = load i32, i32* %0, align 4
+  br label %5
+
+5:                                                ; preds = %1, %3
+  %6 = phi i32 [ %4, %3 ], [ 0, %A ]
+  ret i32 %6
+}
+
+define dso_local i32 @test4b(i32* readonly %0, i1 %cond) "null-pointer-is-valid"="true" {
+; CHECK-LABEL: @test4b(
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "dereferenceable"(i32* [[TMP0:%.*]], i32 4) ]
+; CHECK-NEXT:    br i1 [[COND:%.*]], label [[A:%.*]], label [[B:%.*]]
+; CHECK:       B:
+; CHECK-NEXT:    br label [[A]]
+; CHECK:       A:
+; CHECK-NEXT:    [[TMP2:%.*]] = icmp eq i32* [[TMP0]], null
+; CHECK-NEXT:    br i1 [[TMP2]], label [[TMP5:%.*]], label [[TMP3:%.*]]
+; CHECK:       3:
+; CHECK-NEXT:    [[TMP4:%.*]] = load i32, i32* [[TMP0]], align 4
+; CHECK-NEXT:    br label [[TMP5]]
+; CHECK:       5:
+; CHECK-NEXT:    [[TMP6:%.*]] = phi i32 [ [[TMP4]], [[TMP3]] ], [ 0, [[A]] ]
+; CHECK-NEXT:    ret i32 [[TMP6]]
+;
+  call void @llvm.assume(i1 true) ["dereferenceable"(i32* %0, i32 4)]
+  br i1 %cond, label %A, label %B
+
+B:
+  br label %A
+
+A:
+  %2 = icmp eq i32* %0, null
+  br i1 %2, label %5, label %3
+
+3:                                                ; preds = %1
+  %4 = load i32, i32* %0, align 4
+  br label %5
+
+5:                                                ; preds = %1, %3
+  %6 = phi i32 [ %4, %3 ], [ 0, %A ]
+  ret i32 %6
+}
diff --git a/llvm/test/Transforms/Attributor/nonnull.ll b/llvm/test/Transforms/Attributor/nonnull.ll
--- a/llvm/test/Transforms/Attributor/nonnull.ll
+++ b/llvm/test/Transforms/Attributor/nonnull.ll
@@ -22,6 +22,18 @@
   ret i8* %p
 }
 
+define i8* @test2A(i8* %ret) {
+; ATTRIBUTOR: define nonnull i8* @test2A(i8* nofree nonnull readnone returned %ret)
+  call void @llvm.assume(i1 true) [ "nonnull"(i8* %ret) ]
+  ret i8* %ret
+}
+
+define i8* @test2B(i8* %ret) {
+; ATTRIBUTOR: define nonnull dereferenceable(4) i8* @test2B(i8* nofree nonnull readnone returned dereferenceable(4) %ret)
+  call void @llvm.assume(i1 true) [ "dereferenceable"(i8* %ret, i32 4) ]
+  ret i8* %ret
+}
+
 ; Given an SCC where one of the functions can not be marked nonnull,
 ; can we still mark the other one which is trivially nonnull
 define i8* @scc_binder(i1 %c) {